7ULV

Human DDAH1 soaked with its inactivator S-((4-chloropyridin-2-yl)methyl)-L-cysteine

Summary for 7ULV

• Entry DOI: 10.2210/pdb7ulv/pdb
• Descriptor: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, S-[(pyridin-2-yl)methyl]-L-cysteine (3 entities in total)
• Functional Keywords: ddah1, dimethylargininase, ddah, inactivator, s-((4-chloropyridin-2-yl)methyl)-l-cysteine, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 203014.57

Authors

Zheng, Y.,Butrin, A.,Tuley, A.,Liu, D.,Fast, W. (deposition date: 2022-04-05, release date: 2023-08-30, Last modification date: 2024-10-23)

• Primary citation: Tuley, A.,Zheng, Y.,Tommasi, S.,Butrin, A.,May, K.V.,Ahn, Y.,Reidl, T.C.,Weerakoon, L.,Hulin, J.,Meech, R.,Patel, D.S.,Horton, C.P.,Swartzel, C.J.,Kim, Y.,Silverman, B.R.,Mangoni, A.,Liu, D.,Fast, W.; Optimization of a switchable electrophile fragment into a potent and selective covalent inhibitor of human DDAH1; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.37 Å)