4U6P
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4U7C
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![BU of 4u7c by Molmil](/molmil-images/mine/4u7c) | Structure of DNA polymerase kappa in complex with benzopyrene adducted DNA | Descriptor: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DI(HYDROXYETHYL)ETHER, ... | Authors: | Jha, V.K, Ling, H. | Deposit date: | 2014-07-30 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase kappa. Nucleic Acids Res., 44, 2016
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5W2C
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3M9O
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3M9N
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3M9M
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![BU of 3m9m by Molmil](/molmil-images/mine/3m9m) | |
5W2A
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5T14
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![BU of 5t14 by Molmil](/molmil-images/mine/5t14) | DNA polymerase kappa extending beyond a bulky major benzo[a]pyrene adduct | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA, DNA polymerase kappa, ... | Authors: | Jha, V.K, Ling, H. | Deposit date: | 2016-08-17 | Release date: | 2016-12-21 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis of accurate replication beyond a bulky major benzo[a]pyrene adduct by human DNA polymerase kappa. DNA Repair (Amst.), 49, 2017
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4EYH
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4FBT
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4FBU
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![BU of 4fbu by Molmil](/molmil-images/mine/4fbu) | Dpo4 polymerase pre-insertion binary complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesion | Descriptor: | CALCIUM ION, DNA polymerase IV, DNA primer, ... | Authors: | Kirouac, K, Basu, A, Ling, H. | Deposit date: | 2012-05-23 | Release date: | 2013-06-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural mechanism of replication stalling on a bulky amino-polycyclic aromatic hydrocarbon DNA adduct by a y family DNA polymerase. J.Mol.Biol., 425, 2013
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4EYI
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6BS1
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6BRX
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6CST
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![BU of 6cst by Molmil](/molmil-images/mine/6cst) | Structure of human DNA polymerase kappa with DNA | Descriptor: | 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, CHLORIDE ION, ... | Authors: | Jha, V, Ling, H. | Deposit date: | 2018-03-21 | Release date: | 2019-01-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 2.0 angstrom resolution crystal structure of human pol kappa reveals a new catalytic function of N-clasp in DNA replication. Sci Rep, 8, 2018
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3GV7
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3GV5
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3GV8
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3PR4
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![BU of 3pr4 by Molmil](/molmil-images/mine/3pr4) | Dpo4 Y12A mutant incorporating dADP opposite template dT | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*C)-3'), ... | Authors: | Kirouac, K.N, Suo, Z, Ling, H. | Deposit date: | 2010-11-29 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase. J.Mol.Biol., 407, 2011
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3Q8S
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3PR5
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![BU of 3pr5 by Molmil](/molmil-images/mine/3pr5) | Dpo4 Y12A mutant incorporating ADP opposite template dT | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*C)-3'), ... | Authors: | Kirouac, K.N, Ling, H. | Deposit date: | 2010-11-29 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase. J.Mol.Biol., 407, 2011
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3Q8P
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![BU of 3q8p by Molmil](/molmil-images/mine/3q8p) | Human DNA polymerase iota incorporating dCTP opposite 8-oxo-guanine | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Kirouac, K.N, Ling, H. | Deposit date: | 2011-01-06 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc.Natl.Acad.Sci.USA, 108, 2011
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3Q8Q
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![BU of 3q8q by Molmil](/molmil-images/mine/3q8q) | Human DNA polymerase iota incorporating dATP opposite 8-oxo-guanine | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Kirouac, K.N, Ling, H. | Deposit date: | 2011-01-06 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.031 Å) | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc.Natl.Acad.Sci.USA, 108, 2011
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3Q8R
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![BU of 3q8r by Molmil](/molmil-images/mine/3q8r) | Human DNA polymerase iota incorporating dGTP opposite 8-oxo-guanine | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ... | Authors: | Kirouac, K.N, Ling, H. | Deposit date: | 2011-01-06 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota. Proc.Natl.Acad.Sci.USA, 108, 2011
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2IA6
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![BU of 2ia6 by Molmil](/molmil-images/mine/2ia6) | Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap | Descriptor: | 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 1,2-ETHANEDIOL, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*A)-3', ... | Authors: | Bauer, J, Ling, H, Sayer, J.M, Xing, G, Yagi, H, Jerina, D.M. | Deposit date: | 2006-09-07 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment. Proc.Natl.Acad.Sci.Usa, 104, 2007
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