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PDB: 66 件
2IA6
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BU of 2ia6 by Molmil
Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap
分子名称: 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE, 1,2-ETHANEDIOL, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*A)-3', ...
著者Bauer, J, Ling, H, Sayer, J.M, Xing, G, Yagi, H, Jerina, D.M.
登録日2006-09-07
公開日2007-09-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2IO4
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BU of 2io4 by Molmil
Crystal structure of PCNA12 dimer from Sulfolobus solfataricus.
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, DNA polymerase sliding clamp B, ...
著者Hlinkova, V, Ling, H.
登録日2006-10-09
公開日2008-04-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening.
Acta Crystallogr.,Sect.D, 64, 2008
4U6P
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BU of 4u6p by Molmil
Structural mechanism of error-free bypass of major benzo[a]pyrene adduct by human polymerase kappa
分子名称: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*TP*AP*TP*GP*GP*TP*GP*AP*TP*CP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*GP*AP*TP*CP*AP*C)-3'), ...
著者Jha, V.K, Ling, H.
登録日2014-07-29
公開日2016-01-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.593 Å)
主引用文献Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase kappa.
Nucleic Acids Res., 44, 2016
4U7C
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BU of 4u7c by Molmil
Structure of DNA polymerase kappa in complex with benzopyrene adducted DNA
分子名称: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DI(HYDROXYETHYL)ETHER, ...
著者Jha, V.K, Ling, H.
登録日2014-07-30
公開日2016-01-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase kappa.
Nucleic Acids Res., 44, 2016
3M9M
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BU of 3m9m by Molmil
Crystal Structure of Dpo4 in complex with DNA containing the major cisplatin lesion
分子名称: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, Cisplatin, ...
著者Wong, J.H.Y, Ling, H.
登録日2010-03-22
公開日2010-06-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4.
Embo J., 29, 2010
3M9O
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BU of 3m9o by Molmil
Crystal Structure of Dpo4 in complex with DNA containing the major cisplatin lesion
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Cisplatin, ...
著者Wong, J.H.Y, Ling, H.
登録日2010-03-22
公開日2010-06-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4.
Embo J., 29, 2010
3M9N
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BU of 3m9n by Molmil
Crystal Structure of Dpo4 in complex with DNA containing the major cisplatin lesion
分子名称: CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, Cisplatin, ...
著者Wong, J.H.Y, Ling, H.
登録日2010-03-22
公開日2010-06-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4.
Embo J., 29, 2010
6CST
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BU of 6cst by Molmil
Structure of human DNA polymerase kappa with DNA
分子名称: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, CHLORIDE ION, ...
著者Jha, V, Ling, H.
登録日2018-03-21
公開日2019-01-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献2.0 angstrom resolution crystal structure of human pol kappa reveals a new catalytic function of N-clasp in DNA replication.
Sci Rep, 8, 2018
5W2A
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BU of 5w2a by Molmil
Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dCMPNPP
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*AP*TP*GP*(LDG)P*CP*TP*GP*AP*TP*CP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*GP*AP*TP*CP*AP*G)-3'), ...
著者Jha, V.K, Ling, H.
登録日2017-06-06
公開日2017-10-18
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase kappa.
Chem. Res. Toxicol., 30, 2017
5W2C
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BU of 5w2c by Molmil
Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dAMPNPP
分子名称: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DI(HYDROXYETHYL)ETHER, ...
著者Jha, V.K, Ling, H.
登録日2017-06-06
公開日2017-10-18
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase kappa.
Chem. Res. Toxicol., 30, 2017
4EYH
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BU of 4eyh by Molmil
Human DNA polymerase iota incorporating dCTP opposite N-(deoxyguanosin-8-yl)-1-aminopyrene lesion
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA polymerase iota, DNA primer, ...
著者Kirouac, K, Ling, H.
登録日2012-05-01
公開日2013-01-09
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase.
Nucleic Acids Res., 41, 2013
4FBU
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BU of 4fbu by Molmil
Dpo4 polymerase pre-insertion binary complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesion
分子名称: CALCIUM ION, DNA polymerase IV, DNA primer, ...
著者Kirouac, K, Basu, A, Ling, H.
登録日2012-05-23
公開日2013-06-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural mechanism of replication stalling on a bulky amino-polycyclic aromatic hydrocarbon DNA adduct by a y family DNA polymerase.
J.Mol.Biol., 425, 2013
4FBT
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BU of 4fbt by Molmil
Dpo4 post-insertion complex with the N-(deoxyguanosin-8-yl)-1-aminopyrene lesion
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA polymerase IV, ...
著者Kirouac, K, Ling, H.
登録日2012-05-23
公開日2013-06-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural mechanism of replication stalling on a bulky amino-polycyclic aromatic hydrocarbon DNA adduct by a y family DNA polymerase.
J.Mol.Biol., 425, 2013
4EYI
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BU of 4eyi by Molmil
Human DNA polymerase iota incorporating dATP opposite N-(deoxyguanosin-8-yl)-1-aminopyrene lesion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase iota, DNA primer, ...
著者Kirouac, K, Ling, H.
登録日2012-05-01
公開日2013-01-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase.
Nucleic Acids Res., 41, 2013
3GV7
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BU of 3gv7 by Molmil
Human DNA polymerase iota in complex with T template DNA and incoming dTTP
分子名称: 5'-D(*AP*GP*GP*AP*CP*CP*C)-3', 5'-D(P*AP*TP*GP*GP*GP*TP*CP*CP*T)-3', DNA polymerase iota, ...
著者Kirouac, K.N, Ling, H.
登録日2009-03-30
公開日2009-06-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota
Embo J., 28, 2009
3GV5
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BU of 3gv5 by Molmil
Human DNA polymerase iota in complex with T template DNA and incoming ddADP
分子名称: 2',3'-DIDEOXYADENOSINE-5'-DIPHOSPHATE, 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', 5'-D(P*CP*AP*TP*TP*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', ...
著者Kirouac, K.N, Ling, H.
登録日2009-03-30
公開日2009-06-02
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota
Embo J., 28, 2009
3GV8
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BU of 3gv8 by Molmil
Human DNA polymerase iota in complex with T template DNA and incoming dGTP
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*AP*GP*GP*AP*CP*CP*C)-3', 5'-D(*AP*TP*GP*GP*GP*TP*CP*CP*T)-3', ...
著者Kirouac, K.N, Ling, H.
登録日2009-03-30
公開日2009-06-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota
Embo J., 28, 2009
6BRX
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BU of 6brx by Molmil
Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Cisplatin, DI(HYDROXYETHYL)ETHER, ...
著者Jha, V.K, Ling, H.
登録日2017-12-01
公開日2018-08-22
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
J. Mol. Biol., 430, 2018
6BS1
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BU of 6bs1 by Molmil
Crystal Structure of Human DNA polymerase kappa in complex with DNA containing the major cisplatin lesion
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Cisplatin, DNA (5'-D(*TP*AP*CP*TP*GP*GP*TP*AP*TP*GP*TP*AP*T)-3'), ...
著者Jha, V.K, Ling, H.
登録日2017-12-01
公開日2018-08-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structural Basis for Human DNA Polymerase Kappa to Bypass Cisplatin Intrastrand Cross-Link (Pt-GG) Lesion as an Efficient and Accurate Extender.
J. Mol. Biol., 430, 2018
3PR5
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BU of 3pr5 by Molmil
Dpo4 Y12A mutant incorporating ADP opposite template dT
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*C)-3'), ...
著者Kirouac, K.N, Ling, H.
登録日2010-11-29
公開日2011-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase.
J.Mol.Biol., 407, 2011
3Q8Q
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BU of 3q8q by Molmil
Human DNA polymerase iota incorporating dATP opposite 8-oxo-guanine
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ...
著者Kirouac, K.N, Ling, H.
登録日2011-01-06
公開日2011-02-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.031 Å)
主引用文献Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q8S
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BU of 3q8s by Molmil
Human DNA polymerase iota incorporating dTTP opposite 8-oxo-guanine
分子名称: DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
著者Kirouac, K.N, Ling, H.
登録日2011-01-06
公開日2011-02-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Human DNA polymerase iota incorporating dTTP opposite 8-oxo-guanine
To be Published
3Q8P
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BU of 3q8p by Molmil
Human DNA polymerase iota incorporating dCTP opposite 8-oxo-guanine
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ...
著者Kirouac, K.N, Ling, H.
登録日2011-01-06
公開日2011-02-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Proc.Natl.Acad.Sci.USA, 108, 2011
3Q8R
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BU of 3q8r by Molmil
Human DNA polymerase iota incorporating dGTP opposite 8-oxo-guanine
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*TP*CP*AP*(8OG)P*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), ...
著者Kirouac, K.N, Ling, H.
登録日2011-01-06
公開日2011-02-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PR4
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BU of 3pr4 by Molmil
Dpo4 Y12A mutant incorporating dADP opposite template dT
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*C)-3'), ...
著者Kirouac, K.N, Suo, Z, Ling, H.
登録日2010-11-29
公開日2011-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural mechanism of ribonucleotide discrimination by a Y-family DNA polymerase.
J.Mol.Biol., 407, 2011

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