2CH0
 
 | | Solution structure of the human MAN1 C-terminal domain (residues 655- 775) | | Descriptor: | INNER NUCLEAR MEMBRANE PROTEIN MAN1 | | Authors: | Caputo, S, Couprie, J, Duband-Goulet, I, Lin, F, Braud, S, Gondry, M, Worman, H.J, Gilquin, B, Zinn-Justin, S. | | Deposit date: | 2006-03-10 | | Release date: | 2006-05-16 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain.
J. Biol. Chem., 281, 2006
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2AIZ
 | | Solution structure of peptidoglycan associated lipoprotein from Haemophilus influenza bound to UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine | | Descriptor: | L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine, N-acetyl-beta-muramic acid, Outer membrane protein P6 (Fragment), ... | | Authors: | Parsons, L.M, Lin, F, Orban, J, Structure 2 Function Project (S2F) | | Deposit date: | 2005-08-01 | | Release date: | 2006-03-14 | | Last modified: | 2024-10-30 | | Method: | SOLUTION NMR | | Cite: | Peptidoglycan recognition by pal, an outer membrane lipoprotein.
Biochemistry, 45, 2006
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1NWV
 | | SOLUTION STRUCTURE OF A FUNCTIONALLY ACTIVE COMPONENT OF DECAY ACCELERATING FACTOR | | Descriptor: | Complement decay-accelerating factor | | Authors: | Uhrinova, S, Lin, F, Ball, G, Bromek, K, Uhrin, D, Medof, M.E, Barlow, P.N. | | Deposit date: | 2003-02-07 | | Release date: | 2003-04-22 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a functionally active fragment of decay-accelerating factor
Proc.Natl.Acad.Sci.USA, 100, 2003
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1M11
 | | structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy | | Descriptor: | COAT PROTEIN VP1, COAT PROTEIN VP2, COAT PROTEIN VP3, ... | | Authors: | He, Y, Lin, F, Chipman, P.R, Bator, C.M, Baker, T.S, Shoham, M, Kuhn, R.J, Medof, M.E, Rossmann, M.G. | | Deposit date: | 2002-06-17 | | Release date: | 2002-08-28 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (16 Å) | | Cite: | Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex.
Proc.Natl.Acad.Sci.USA, 99, 2002
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2QZH
 | | SCR2/3 of DAF from the NMR structure 1nwv fitted into a cryoEM reconstruction of CVB3-RD complexed with DAF | | Descriptor: | Complement decay-accelerating factor | | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | | Deposit date: | 2007-08-16 | | Release date: | 2007-10-30 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
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2QZD
 | | Fitted structure of SCR4 of DAF into cryoEM density | | Descriptor: | Complement decay-accelerating factor | | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | | Deposit date: | 2007-08-16 | | Release date: | 2007-10-30 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
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2QZF
 | | SCR1 of DAF from 1ojv fitted into cryoEM density | | Descriptor: | Complement decay-accelerating factor | | Authors: | Hafenstein, S, Bowman, V.D, Chipman, P.R, Bator Kelly, C.M, Lin, F, Medof, M.E, Rossmann, M.G. | | Deposit date: | 2007-08-16 | | Release date: | 2007-10-30 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Interaction of decay-accelerating factor with coxsackievirus b3.
J.Virol., 81, 2007
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6FCE
 | | NMR ensemble of Macrocyclic Peptidomimetic Containing Constrained a,a-dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors | | Descriptor: | ACP-HIS-DPHE-ARG-TRP-ASP-NH2 | | Authors: | Brancaccio, D, Carotenuto, A, Grieco, P, Merlino, F, Zhou, Y, Cai, M, Yousif, A.M, Di Maro, S, Novellino, E, Hruby, V.J. | | Deposit date: | 2017-12-20 | | Release date: | 2018-04-25 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Development of Macrocyclic Peptidomimetics Containing Constrained alpha , alpha-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors.
J. Med. Chem., 61, 2018
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6S4A
 | | Structure of human MTHFD2 in complex with TH9028 | | Descriptor: | (2~{S})-2-[[5-[[2,4-bis(azanyl)-6-oxidanylidene-5~{H}-pyrimidin-5-yl]carbamoylamino]pyridin-2-yl]carbonylamino]-4-(1~{H}-1,2,3,4-tetrazol-5-yl)butanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... | | Authors: | Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | | Deposit date: | 2019-06-27 | | Release date: | 2021-07-07 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
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6S4F
 | | Structure of human MTHFD2 in complex with TH9619 | | Descriptor: | (E,4S)-4-[[5-[2-[2,6-bis(azanyl)-4-oxidanylidene-1H-pyrimidin-5-yl]ethanoylamino]-3-fluoranyl-pyridin-2-yl]carbonylamino]pent-2-enedioic acid, ADENOSINE-5'-DIPHOSPHATE, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ... | | Authors: | Scaletti, E.R, Gustafsson, R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | | Deposit date: | 2019-06-27 | | Release date: | 2021-07-07 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
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6S4E
 | | Structure of human MTHFD2 in complex with TH7299 | | Descriptor: | (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | | Authors: | Gustafsson, R, Scaletti, E.R, Bonagas, N, Gustafsson, N.M, Henriksson, M, Abdurakhmanov, E, Andersson, Y, Bengtsson, C, Borhade, S, Desroses, M, Farnegardh, K, Garg, N, Gokturk, C, Haraldsson, M, Iliev, P, Jarvius, M, Jemth, A.S, Kalderen, C, Karsten, S, Klingegard, F, Koolmeister, T, Martens, U, Llona-Minguez, S, Loseva, O, Marttila, P, Michel, M, Moulson, R, Nordstrom, H, Paulin, C, Pham, T, Pudelko, L, Rasti, A, Roos, A.K, Sarno, A, Sandberg, L, Scobie, M, Sjoberg, B, Svensson, R, Unterlass, J.E, Vallin, K, Vo, D, Wiita, E, Warpman-Berglund, U, Homan, E.J, Helleday, T, Stenmark, P. | | Deposit date: | 2019-06-27 | | Release date: | 2021-07-07 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer, 3, 2022
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6OQK
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6OQ9
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6OKY
 | | Solution structure of truncated peptide from PAMap53 | | Descriptor: | Plasminogen-binding group A streptococcal M-like protein PAM | | Authors: | Yuan, Y, Castellino, F.J. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-26 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
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6QXB
 | | NMR structure of peptide 7, characterized by a cis-4-amino-Pro residue, with a significant lower MIC on E. coli | | Descriptor: | PHE-VAL-CAP-TRP-PHE-SER-LYS-PHE-LEU-GLY-ARG-ILE-LEU-NH2 | | Authors: | Brancaccio, D, Carotenuto, A, Merlino, F, Grieco, P, Novellino, E. | | Deposit date: | 2019-03-07 | | Release date: | 2019-05-29 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L.
Chemmedchem, 14, 2019
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6QXC
 | | NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa. | | Descriptor: | PHE-VAL-TCP-TRP-PHE-SER-LYS-PHE-LEU-GLY-ARG-ILE-LEU-NH2 | | Authors: | Brancaccio, D, Carotenuto, A, Merlino, F, Grieco, P, Novellino, E. | | Deposit date: | 2019-03-07 | | Release date: | 2019-05-29 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L.
Chemmedchem, 14, 2019
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6FOE
 | | BaxB01 Fab fragment | | Descriptor: | Fab BaxB01 heavy chain, Fab BaxB01 light chain | | Authors: | Hollerweger, J, Schinagl, A, Kerschbaumer, R.J, Scheiflinger, F, Thiele, M, Goettig, P, Brandstetter, H. | | Deposit date: | 2018-02-07 | | Release date: | 2018-02-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Role of the Cysteine 81 Residue of Macrophage Migration Inhibitory Factor as a Molecular Redox Switch.
Biochemistry, 57, 2018
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6OKX
 | | Solution structure of VEK50RH1/AA | | Descriptor: | Plasminogen-binding group A streptococcal M-like protein PAM | | Authors: | Yuan, Y, Castellino, F.J. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-26 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
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6OQJ
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6OKW
 | | Solution structure of VEK50 | | Descriptor: | Plasminogen-binding group A streptococcal M-like protein PAM | | Authors: | Yuan, Y, Castellino, F.J. | | Deposit date: | 2019-04-15 | | Release date: | 2020-02-26 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes.
J.Struct.Biol., 208, 2019
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8Q72
 | | E. coli plasmid-borne JetABCD(E248A) core in a cleavage-competent state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Circular plasmid DNA (1840-MER), JetA, ... | | Authors: | Roisne-Hamelin, F, Li, Y, Gruber, S. | | Deposit date: | 2023-08-15 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.17 Å) | | Cite: | Structural basis for plasmid restriction by SMC JET nuclease.
Mol.Cell, 84, 2024
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8BFN
 | | E. coli Wadjet JetABC dimer of dimers | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, JetA, JetB, ... | | Authors: | Roisne-Hamelin, F, Beckert, B, Myasnikov, A, Li, Y, Gruber, S. | | Deposit date: | 2022-10-26 | | Release date: | 2022-12-14 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage.
Mol.Cell, 82, 2022
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6HVC
 | | NMR structure of Urotensin Peptide Asp-c[Cys-Phe-Trp-(N-Me)Lys-Tyr-Cys]-Val in SDS solution | | Descriptor: | Urotensin-2 | | Authors: | Brancaccio, D, Carotenuto, A, Merlino, F, Billard, E, Yousif, A.M, Di Maro, S, Abate, L, Bellavita, R, D'Emmanuele di Villa Bianca, R, Santicioli, P, Marinelli, L, Novellino, E, Hebert, T.E, Lubell, W.D, Chatenet, D, Grieco, P. | | Deposit date: | 2018-10-10 | | Release date: | 2019-01-16 | | Last modified: | 2019-04-24 | | Method: | SOLUTION NMR | | Cite: | Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.
J.Med.Chem., 62, 2019
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5HPG
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6HVB
 | | NMR structure of Urotensin Peptide Asp-c[Cys-Phe-(N-Me)Trp-Lys-Tyr-Cys]-Val in SDS solution | | Descriptor: | Urotensin-2 | | Authors: | Brancaccio, D, Carotenuto, A, Merlino, F, Billard, E, Yousif, A.M, Di Maro, S, Abate, L, Bellavita, R, D'Emmanuele di Villa Bianca, R, Santicioli, P, Marinelli, L, Novellino, E, Hebert, T.E, Lubell, W.D, Chatenet, D, Grieco, P. | | Deposit date: | 2018-10-10 | | Release date: | 2019-01-16 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.
J.Med.Chem., 62, 2019
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