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PDB: 18 results

7Y0G
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Crystal structure of anti-mPEG h15-2b Fab
Descriptor: 15-2b heavy chain, 15-2b light chain, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL
Authors:Chang, C.Y, Nguyen, T.M.T, Lin, E.C, Su, Y.C.
Deposit date:2022-06-05
Release date:2022-08-10
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group.
Commun Chem, 5, 2022
7Y5I
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Crystal structure of CmnC in complex with L-homoarginine
Descriptor: ARGININE, CmnC, FE (III) ION, ...
Authors:Hsiao, Y.H, Huang, S.J, Lin, E.C, Lee, Y.C, Chang, C.Y.
Deposit date:2022-06-17
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Front Chem, 10, 2022
7Y5P
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Crystal structure of CmnC in complex with L-arginine and alpha-KG
Descriptor: 2-OXOGLUTARIC ACID, ARGININE, CmnC, ...
Authors:Hsiao, Y.H, Huang, S.J, Lin, E.C, Lee, Y.C, Chang, C.Y.
Deposit date:2022-06-17
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Front Chem, 10, 2022
7YHE
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Crystal structure of the triple mutant CmnC-L136Q,S138G,D249Y in complex with alpha-KG
Descriptor: 2-OXOGLUTARIC ACID, CmnC, FE (III) ION, ...
Authors:Huang, S.J, Hsiao, Y.H, Lin, E.C, Hsiao, P.Y, Chang, C.Y.
Deposit date:2022-07-13
Release date:2023-07-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Front Chem, 10, 2022
7YW9
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BU of 7yw9 by Molmil
Crystal structure of the triple mutant CmnC-L136Q,S138G,D249Y in complex with alpha-KG
Descriptor: ACETATE ION, CmnC, D-ARGININE, ...
Authors:Huang, S.J, Hsiao, Y.H, Lin, E.C, Hsiao, P.Y, Chang, C.Y.
Deposit date:2022-08-22
Release date:2023-08-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Front Chem, 10, 2022
7VGN
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Crystal structure of CmnC
Descriptor: 2-OXOGLUTARIC ACID, ACETATE ION, CmnC, ...
Authors:Huang, S.J, Hsiao, Y.H, Lin, E.C, Lee, Y.C, Zheng, Y.Z, Chang, C.Y.
Deposit date:2021-09-17
Release date:2022-09-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Front Chem, 10, 2022
7VGL
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Crystal structure of CmnC
Descriptor: ACETATE ION, CmnC
Authors:Hsiao, Y.H, Huang, S.J, Lin, E.C, Lee, Y.C, Zheng, Y.Z, Chang, C.Y.
Deposit date:2021-09-17
Release date:2022-09-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Front Chem, 10, 2022
7Y5F
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BU of 7y5f by Molmil
Crystal structure of CmnC in complex with L-homoarginine
Descriptor: CmnC, FE (III) ION, L(+)-TARTARIC ACID, ...
Authors:Hsiao, Y.H, Huang, S.J, Lin, E.C, Lee, Y.C, Chang, C.Y.
Deposit date:2022-06-17
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Front Chem, 10, 2022
7V5S
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BU of 7v5s by Molmil
Crystal structure of human bleomycin hydrolase C73A mutant
Descriptor: Bleomycin hydrolase, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL
Authors:Chang, C.Y, Zheng, Y.Z, Huang, S.J, Wang, Y.L, Toh, S.I, Lin, E.C.
Deposit date:2021-08-18
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease.
Chembiochem, 23, 2022
7V5L
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BU of 7v5l by Molmil
Crystal structure of human bleomycin hydrolase
Descriptor: Bleomycin hydrolase
Authors:Chang, C.Y, Zheng, Y.Z, Huang, S.J, Wang, Y.L, Toh, S.I, Lin, E.C.
Deposit date:2021-08-17
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease.
Chembiochem, 23, 2022
7V5T
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BU of 7v5t by Molmil
Crystal structure of human bleomycin hydrolase C73S mutant
Descriptor: Bleomycin hydrolase
Authors:Chang, C.Y, Zheng, Y.Z, Huang, S.J, Wang, Y.L, Toh, S.I, Lin, E.C.
Deposit date:2021-08-18
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease.
Chembiochem, 23, 2022
2N28
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BU of 2n28 by Molmil
Solid-state NMR structure of Vpu
Descriptor: Protein Vpu
Authors:Zhang, H, Lin, E.C, Tian, Y, Das, B.B, Opella, S.J.
Deposit date:2015-05-01
Release date:2015-09-30
Last modified:2024-05-01
Method:SOLID-STATE NMR
Cite:Structural determination of virus protein U from HIV-1 by NMR in membrane environments.
Biochim.Biophys.Acta, 1848, 2015
7XF9
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BU of 7xf9 by Molmil
Crystal structure of human bleomycin hydrolase H372A mutant
Descriptor: Bleomycin hydrolase
Authors:Chang, C.Y, Zheng, Y.Z, Huang, S.J, Wang, Y.L, Toh, S.I, Lin, E.C.
Deposit date:2022-04-01
Release date:2022-06-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease.
Chembiochem, 23, 2022
2N29
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BU of 2n29 by Molmil
Solution-state NMR structure of Vpu cytoplasmic domain
Descriptor: Protein Vpu
Authors:Zhang, H, Lin, E.C, Tian, Y, Das, B.B, Opella, S.J.
Deposit date:2015-05-01
Release date:2015-09-30
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural determination of virus protein U from HIV-1 by NMR in membrane environments.
Biochim.Biophys.Acta, 1848, 2015
8TB5
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BU of 8tb5 by Molmil
TYK2 JH2 bound to Compound7
Descriptor: ACETATE ION, N-{(3P)-3-[3-(dimethylsulfamoyl)phenyl]-1H-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Argiriadi, M.A, Van Epps, S.A, Breinlinger, E.C.
Deposit date:2023-06-28
Release date:2023-10-18
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712.
J.Med.Chem., 66, 2023
8TB6
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BU of 8tb6 by Molmil
TYK2 JH2 bound to Compound14
Descriptor: N-[(3M)-3-{6-[(3R)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1H-pyrrolo[2,3-c]pyridin-5-yl]urea, Non-receptor tyrosine-protein kinase TYK2
Authors:Argiriadi, M.A, Van Epps, S.A, Breinlinger, E.C.
Deposit date:2023-06-28
Release date:2023-10-18
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712.
J.Med.Chem., 66, 2023
6SLZ
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BU of 6slz by Molmil
Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist
Descriptor: (2~{S})-1-[2,4-bis(chloranyl)-3-[[2-methyl-4-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]carbonyl-~{N}-methyl-pyrrolidine-2-carboxamide, Nuclear receptor ROR-gamma
Authors:Amaudrut, J, Argiriadi, M.A, Barth, M, Breinlinger, E.C, Calderwood, D.J, Cusack, K.P, Kort, M.E, Montalbetti, C, Potin, D, Poupardin, O, Spitzer, L.
Deposit date:2019-08-21
Release date:2020-09-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist
To Be Published
6Q2W
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BU of 6q2w by Molmil
Crystal structure of human ROR gamma LBD in complex with a quinoline sulfonamide inverse agonist
Descriptor: (2~{S})-1-[2,4-bis(chloranyl)-3-[[4-imidazol-1-yl-2-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]sulfonyl-~{N}-methyl-pyrrolidine-2-carboxamide, Nuclear receptor ROR-gamma
Authors:Ciesielski, F, Amaudrut, J, Argiriadi, M.A, Barth, M, Breinlinger, E.C, Calderwood, D.J, Cusack, K.P, Kort, M.E, Montalbetti, C, Potin, D, Poupardin, O, Spitzer, L.
Deposit date:2018-12-03
Release date:2019-05-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active ROR gamma inverse agonists.
Bioorg.Med.Chem.Lett., 29, 2019

227561

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