8TB5

TYK2 JH2 bound to Compound7

Summary for 8TB5

Entry DOI	10.2210/pdb8tb5/pdb
Descriptor	Non-receptor tyrosine-protein kinase TYK2, ACETATE ION, N-{(3P)-3-[3-(dimethylsulfamoyl)phenyl]-1H-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide, ... (4 entities in total)
Functional Keywords	tyk2, pseudokinase, azaindole, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	73873.59
Authors	Argiriadi, M.A.,Van Epps, S.A.,Breinlinger, E.C. (deposition date: 2023-06-28, release date: 2023-10-18, Last modification date: 2023-11-08)
Primary citation	Breinlinger, E.,Van Epps, S.,Friedman, M.,Argiriadi, M.,Chien, E.,Chhor, G.,Cowart, M.,Dunstan, T.,Graff, C.,Hardee, D.,Herold, J.M.,Little, A.,McCarthy, R.,Parmentier, J.,Perham, M.,Qiu, W.,Schrimpf, M.,Vargo, T.,Webster, M.P.,Wu, F.,Bennett, D.,Edmunds, J. Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. J.Med.Chem., 66:14335-14356, 2023 Cited by PubMed: 37823891 DOI: 10.1021/acs.jmedchem.3c01373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation