8TB5

TYK2 JH2 bound to Compound7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Non-receptor tyrosine-protein kinase TYK2	polymer	326	36493.3	2	UniProt (P29597) Pfam (PF07714) In PDB	Homo sapiens (human)
2	A, B	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
3	A, B	N-{(3P)-3-[3-(dimethylsulfamoyl)phenyl]-1H-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide	non-polymer		384.5	2	Chemie (ZOQ)
4		water	water		18.0	128	Chemie (HOH)

Sequence modifications

A, B: 566 - 870 (UniProt: P29597)

PDB	External Database	Details
Ala 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag
Gly 556	-	expression tag
Ala 557	-	expression tag
Leu 558	-	expression tag
Glu 559	-	expression tag
Val 560	-	expression tag
Leu 561	-	expression tag
Phe 562	-	expression tag
Gln 563	-	expression tag
Gly 564	-	expression tag
Pro 565	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72986.6
Non-Polymers*	Number of molecules	4
	Total formula weight	887.0
All*	Total formula weight	73873.6

*Water molecules are not included.