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PDB: 372 件
1FG8
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STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
分子名称: N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN
著者Mahalingam, B, Louis, J.M, Harrison, R.W, Weber, I.T.
登録日2000-07-25
公開日2001-06-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43, 2001
1NAF
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Crystal structure of the human GGA1 GAT domain
分子名称: ADP-ribosylation factor binding protein GGA1
著者Collins, B.M, Watson, P.J, Owen, D.J.
登録日2002-11-27
公開日2003-03-25
最終更新日2018-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The Structure of the GGA1-GAT Domain Reveals the Molecular Basis for ARF Binding and Membrane Association of GGAs
Dev.Cell, 4, 2003
1DW6
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Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
分子名称: HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
著者Mahalingam, B, Louis, J.M, Reed, C.C, Adomat, J.M, Krouse, J, Wang, Y.F, Harrison, R.W, Weber, I.T.
登録日2000-01-24
公開日2000-07-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
1DAZ
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Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
分子名称: HIV-1 PROTEASE (RETROPEPSIN), N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide
著者Mahalingam, B, Louis, J.M, Reed, C.C, Adomat, J.M, Krouse, J, Wang, Y.F, Harrison, R.W, Weber, I.T.
登録日1999-11-01
公開日2000-05-03
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263, 1999
6KQJ
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309 K cryoEM structure of Sso-KARI in complex with Mg2+, NADH and CPD
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Ketol-acid reductoisomerase, MAGNESIUM ION, ...
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-18
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.54 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KPJ
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298 K cryoEM structure of Sso-KARI in complex with Mg2+, NADH and CPD
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Ketol-acid reductoisomerase, MAGNESIUM ION, ...
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-15
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.56 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KPA
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277 K cryoEM structure of Sso-KARI in complex with Mg2+, NADH and CPD
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Ketol-acid reductoisomerase, MAGNESIUM ION, ...
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-15
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KPH
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343 K cryoEM structure of Sso-KARI in complex with Mg2+, NADH and CPD
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Ketol-acid reductoisomerase, MAGNESIUM ION, ...
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-15
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.41 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KQK
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323 K cryoEM structure of Sso-KARI in complex with Mg2+, NADH and CPD
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Ketol-acid reductoisomerase, MAGNESIUM ION, ...
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-18
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.17 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KOU
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277 K cryoEM structure of Sso-KARI in complex with magnesium ions
分子名称: Ketol-acid reductoisomerase, MAGNESIUM ION
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-13
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.43 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KQ4
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323 K cryoEM structure of Sso-KARI in complex with Mg2+
分子名称: Ketol-acid reductoisomerase, MAGNESIUM ION
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-16
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KPI
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BU of 6kpi by Molmil
298 K cryoEM structure of Sso-KARI in complex with Mg2+
分子名称: Ketol-acid reductoisomerase, MAGNESIUM ION
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-15
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.43 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KQO
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328 K cryoEM structure of Sso-KARI in complex with Mg2+, NADH and CPD
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Ketol-acid reductoisomerase, MAGNESIUM ION, ...
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-18
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.52 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KPK
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BU of 6kpk by Molmil
309 K cryoEM structure of Sso-KARI in complex with Mg2+
分子名称: Ketol-acid reductoisomerase, MAGNESIUM ION
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-15
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.3 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KPE
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BU of 6kpe by Molmil
343 K cryoEM structure of Sso-KARI in complex with Mg2+
分子名称: Ketol-acid reductoisomerase, MAGNESIUM ION
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-15
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6KQ8
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328 K cryoEM structure of Sso-KARI in complex with Mg2+
分子名称: Ketol-acid reductoisomerase, MAGNESIUM ION
著者Chen, C.Y, Chang, Y.C, Lin, B.L, Huang, C.H, Tsai, M.D.
登録日2019-08-16
公開日2020-03-25
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Temperature-Resolved Cryo-EM Uncovers Structural Bases of Temperature-Dependent Enzyme Functions.
J.Am.Chem.Soc., 141, 2019
6JD1
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Cryo-EM Structure of Sulfolobus solfataricus ketol-acid reductoisomerase (Sso-KARI) in complex with Mg2+, NADH, and CPD at pH7.5
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MAGNESIUM ION, Putative ketol-acid reductoisomerase 2, ...
著者Chen, C.Y, Chang, Y.C, Lin, K.F, Huang, C.H, Lin, B.L, Ko, T.P, Hsieh, D.L, Tsai, M.D.
登録日2019-01-30
公開日2019-04-17
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
J. Am. Chem. Soc., 141, 2019
6JD2
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Crystal structure of Sulfolobus solfataricus ketol-acid reductoisomerase (Sso-KARI) in complex with Mg2+ at pH8.5
分子名称: BETA-MERCAPTOETHANOL, MAGNESIUM ION, Putative ketol-acid reductoisomerase 2
著者Chen, C.Y, Chang, Y.C, Lin, K.F, Huang, C.H, Lin, B.L, Ko, T.P, Hsieh, D.L, Tsai, M.D.
登録日2019-01-30
公開日2019-08-14
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
J.Am.Chem.Soc., 141, 2019
6JCW
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Cryo-EM Structure of Sulfolobus solfataricus ketol-acid reductoisomerase (Sso-KARI) with Mg2+ at pH8.5
分子名称: MAGNESIUM ION, ketol-acid reductoisomerase
著者Chen, C.Y, Chang, Y.C, Lin, K.F, Huang, C.H, Lin, B.L, Ko, T.P, Hsieh, D.L, Tsai, M.D.
登録日2019-01-30
公開日2019-04-17
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
J. Am. Chem. Soc., 141, 2019
6JCZ
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Cryo-EM Structure of Sulfolobus solfataricus ketol-acid reductoisomerase (Sso-KARI) in complex with Mg2+, NADPH, and CPD at pH7.5
分子名称: MAGNESIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative ketol-acid reductoisomerase 2, ...
著者Chen, C.Y, Chang, Y.C, Lin, K.F, Huang, C.H, Lin, B.L, Ko, T.P, Hsieh, D.L, Tsai, M.D.
登録日2019-01-30
公開日2019-04-17
最終更新日2019-05-01
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
J. Am. Chem. Soc., 141, 2019
5YEQ
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The structure of Sac-KARI protein
分子名称: 1,2-ETHANEDIOL, Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, ...
著者Ko, T.P, Chen, C.Y, Lin, K.F, Lin, B.L, Huang, C.H, Chiang, C.H, Horng, J.C, Tsai, M.D.
登録日2017-09-19
公開日2018-07-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献NADH/NADPH bi-cofactor-utilizing and thermoactive ketol-acid reductoisomerase from Sulfolobus acidocaldarius
Sci Rep, 8, 2018
6JCV
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BU of 6jcv by Molmil
Cryo-EM structure of Sulfolobus solfataricus ketol-acid reductoisomerase (Sso-KARI) with Mg2+ at pH7.5
分子名称: MAGNESIUM ION, Putative ketol-acid reductoisomerase 2
著者Chen, C.Y, Chang, Y.C, Lin, K.F, Huang, C.H, Lin, B.L, Ko, T.P, Hsieh, D.L, Tsai, M.D.
登録日2019-01-30
公開日2019-04-17
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Use of Cryo-EM To Uncover Structural Bases of pH Effect and Cofactor Bispecificity of Ketol-Acid Reductoisomerase.
J. Am. Chem. Soc., 141, 2019
6QNZ
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Crystal structure of the site-specific DNA nickase N.BspD6I E418A Mutant
分子名称: GLYCEROL, Heterodimeric restriction endonuclease R.BspD6I large subunit, PHOSPHATE ION
著者Artyukh, R.I, Kachalova, G.S, Yunusova, A.K, Gabdulkhakov, A.G, Fatkhullin, B.F, Atanasov, B.P, Perevyazova, T.A, Popov, A.N, Zheleznaya, L.A.
登録日2019-02-12
公開日2020-03-04
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献The key role of E418 carboxyl group in the formation of Nt.BspD6I nickase active site: Structural and functional properties of Nt.BspD6I E418A mutant.
J.Struct.Biol., 210, 2020
3LQF
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BU of 3lqf by Molmil
Crystal structure of the short-chain dehydrogenase Galactitol-Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD and erythritol
分子名称: Galactitol dehydrogenase, MAGNESIUM ION, MESO-ERYTHRITOL, ...
著者Carius, Y, Christian, H, Faust, A, Kornberger, P, Zander, U, Klink, B.U, Kohring, G.W, Giffhorn, F, Scheidig, A.J.
登録日2010-02-09
公開日2010-04-21
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insight into substrate differentiation of the sugar-metabolizing enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D.
J.Biol.Chem., 285, 2010
7NEV
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Structure of the hemiacetal complex between the SARS-CoV-2 Main Protease and Leupeptin
分子名称: 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
著者Guenther, S, Reinke, P.Y.A, Oberthuer, D, Yefanov, O, Gelisio, L, Ginn, H.M, Lieske, J, Domaracky, M, Brehm, W, Rahmani Mashhour, A, White, T.A, Knoska, J, Pena Esperanza, G, Koua, F, Tolstikova, A, Groessler, M, Fischer, P, Hennicke, V, Fleckenstein, H, Trost, F, Galchenkova, M, Gevorkov, Y, Li, C, Awel, S, Xavier, P.L, Ullah, N, Andaleeb, H, Falke, S, Alves Franca, B, Schwinzer, M, Brognaro, H, Werner, N, Perbandt, M, Tidow, H, Seychell, B, Beck, T, Meier, S, Zaitsev-Doyle, J.J, Rogers, C, Gieseler, H, Melo, D, Monteiro, D.C.F, Dunkel, I, Lane, T.J, Peck, A, Saouane, S, Hakanpaeae, J, Meyer, J, Noei, H, Gribbon, P, Ellinger, B, Kuzikov, M, Wolf, M, Zhang, L, Ehrt, C, Pletzer-Zelgert, J, Wollenhaupt, J, Feiler, C, Weiss, M, Schluenzen, F, Schulz, E.C, Mehrabi, P, Norton-Baker, B, Schmidt, C, Lorenzen, K, Schubert, R, Sun, X, Han, H, Chari, A, Fernandez Garcia, Y, Turk, D, Hilgenfeld, R, Rarey, M, Zaliani, A, Chapman, H.N, Pearson, A, Betzel, C, Meents, A.
登録日2021-02-05
公開日2021-03-03
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Science, 372, 2021

224004

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