1DAZ
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease
Summary for 1DAZ
Entry DOI | 10.2210/pdb1daz/pdb |
Related | 1A94 |
Related PRD ID | PRD_000349 |
Descriptor | HIV-1 PROTEASE (RETROPEPSIN), N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total) |
Functional Keywords | hiv-1 protease, hydrolase-hydrolase inhibitor complex, reduced peptide inhibitor, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22282.36 |
Authors | Mahalingam, B.,Louis, J.M.,Reed, C.C.,Adomat, J.M.,Krouse, J.,Wang, Y.F.,Harrison, R.W.,Weber, I.T. (deposition date: 1999-11-01, release date: 2000-05-03, Last modification date: 2024-03-13) |
Primary citation | Mahalingam, B.,Louis, J.M.,Reed, C.C.,Adomat, J.M.,Krouse, J.,Wang, Y.F.,Harrison, R.W.,Weber, I.T. Structural and kinetic analysis of drug resistant mutants of HIV-1 protease. Eur.J.Biochem., 263:238-245, 1999 Cited by PubMed: 10429209DOI: 10.1046/j.1432-1327.1999.00514.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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