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PDB: 208 件
2L9C
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BU of 2l9c by Molmil
Structural insights into the specificity of darcin, an atypical major urinary protein.
分子名称: Darcin
著者Phelan, M.M, Mclean, L, Beynon, R.J, Hurst, J.L, Lian, L.
登録日2011-02-07
公開日2012-02-08
最終更新日2023-12-06
実験手法SOLUTION NMR
主引用文献Structural insights into the specificity of darcin, an atypical major urinary protein.
To be Published
2MHO
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BU of 2mho by Molmil
Solution State Structure PSD-95 PDZ1 with 5HT2C Receptor peptide
分子名称: Disks large homolog 4, peptide from 5-hydroxytryptamine receptor 2C
著者Dorr, L.A, Phelan, M.M, Lian, L.
登録日2013-11-29
公開日2014-03-12
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Interactions of the 5-Hydroxytryptamine Receptor 2a and 2c Variants with the PSD-MAGUK proteins, PSD-95 and SAP997
To be Published
2LNT
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BU of 2lnt by Molmil
Solution structure of E60A mutant AGR2
分子名称: Anterior gradient protein 2 homolog
著者Patel, P, Clarke, C.J, Barraclough, D.L, Rudland, P.S, Barraclough, R, Lian, L.
登録日2012-01-04
公開日2013-01-09
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion.
J.Mol.Biol., 425, 2013
2LNS
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BU of 2lns by Molmil
Solution structure of AGR2 residues 41-175
分子名称: Anterior gradient protein 2 homolog
著者Patel, P, Clarke, C.J, Barraclough, D.L, Rudland, P.S, Barraclough, R, Lian, L.
登録日2012-01-04
公開日2013-01-09
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion.
J.Mol.Biol., 425, 2013
2LV7
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BU of 2lv7 by Molmil
Solution structure of Ca2+-bound CaBP7 N-terminal doman
分子名称: CALCIUM ION, Calcium-binding protein 7
著者Mccue, H.V, Patel, P, Herbert, A.P, Lian, L, Burgoyne, R.D, Haynes, L.P.
登録日2012-06-29
公開日2012-09-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution NMR Structure of the Ca2+-bound N-terminal Domain of CaBP7: A REGULATOR OF GOLGI TRAFFICKING.
J.Biol.Chem., 287, 2012
2N04
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BU of 2n04 by Molmil
Solution Structure of the phosphorylated N-terminal region of Human Cysteine String Protein (CSP)
分子名称: DnaJ homolog subfamily C member 5
著者Patel, P, Lian, L, Morgan, A, Burgoyne, R.
登録日2015-03-04
公開日2016-07-13
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch.
Structure, 24, 2016
2N05
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BU of 2n05 by Molmil
Solution Structure of the non-phosphorylated N-terminal region of Human Cysteine String Protein (CSP)
分子名称: DnaJ homolog subfamily C member 5
著者Patel, P, Lian, L, Morgan, A, Burgoyne, R.
登録日2015-03-04
公開日2016-07-13
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch.
Structure, 24, 2016
8IJ1
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BU of 8ij1 by Molmil
Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex
分子名称: Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ...
著者Dai, Z, Liang, L, Yin, Y.X.
登録日2023-02-24
公開日2024-02-28
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
5K5X
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BU of 5k5x by Molmil
Crystal structure of human PDGFRA
分子名称: Platelet-derived growth factor receptor alpha, SULFATE ION
著者Yan, X.E, Liang, L, Yun, C.H.
登録日2016-05-24
公開日2016-08-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.168 Å)
主引用文献Structural and biochemical studies of the PDGFRA kinase domain
Biochem.Biophys.Res.Commun., 477, 2016
7STY
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BU of 7sty by Molmil
Crystal structure of human CORO1C
分子名称: Coronin-1C
著者Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
登録日2021-11-15
公開日2021-12-01
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of human CORO1C
To Be Published
7SUL
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BU of 7sul by Molmil
Crystal structure of the WD-repeat domain of human SEC31A
分子名称: Protein transport protein Sec31A
著者Zeng, H, Dong, A, Loppnau, P, Hutchinson, A, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
登録日2021-11-17
公開日2021-12-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the WD-repeat domain of human SEC31A
To Be Published
7SSE
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BU of 7sse by Molmil
Crystal structure of the WDR domain of human DCAF1 in complex with CYCA-117-70
分子名称: DDB1- and CUL4-associated factor 1, N-[(3R)-1-(3-fluorophenyl)piperidin-3-yl]-6-(morpholin-4-yl)pyrimidin-4-amine
著者Kimani, S, Owen, J, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Shahani, V.M, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
登録日2021-11-10
公開日2021-12-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets.
J.Chem.Inf.Model., 63, 2023
7T39
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BU of 7t39 by Molmil
Co-crystal structure of human PRMT9 in complex with MT221 inhibitor
分子名称: 7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Protein arginine N-methyltransferase 9
著者Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
登録日2021-12-07
公開日2021-12-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Co-crystal structure of human PRMT9 in complex with MT221 inhibitor
To Be Published
6CE8
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BU of 6ce8 by Molmil
Crystal structure of fragment 2-(Benzo[d]thiazol-2-yl)acetic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
分子名称: (1,3-benzothiazol-2-yl)acetic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ...
著者Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6CEC
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BU of 6cec by Molmil
Crystal structure of fragment 3-(3-Methoxy-2-quinoxalinyl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
分子名称: 3-(3-methoxyquinoxalin-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ...
著者Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Franzoni, I, Ravichandran, M, Lautens, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6CEF
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BU of 6cef by Molmil
Crystal structure of fragment 3-(1,3-Benzothiazol-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
分子名称: 3-(1,3-benzothiazol-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ...
著者Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6CEA
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BU of 6cea by Molmil
Crystal structure of fragment 3-(quinolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
分子名称: 3-(quinolin-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ...
著者Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6CEE
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BU of 6cee by Molmil
Crystal structure of fragment 3-(1-Methyl-2-oxo-1,2-dihydroquinoxalin-3-yl)propionic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
分子名称: 3-(4-methyl-3-oxo-3,4-dihydroquinoxalin-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ...
著者Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Franzoni, I, Ravichandran, M, Lautens, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6CE6
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BU of 6ce6 by Molmil
Structure of HDAC6 zinc-finger ubiquitin binding domain soaked with 3,3'-(benzo[1,2-d:5,4-d']bis(thiazole)-2,6-diyl)dipropionic acid
分子名称: 3,3'-(benzo[1,2-d:5,4-d']bis[1,3]thiazole-2,6-diyl)dipropanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ...
著者Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6CED
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BU of 6ced by Molmil
Crystal structure of fragment 3-(3-Methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain
分子名称: 3-(3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ...
著者Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Franzoni, I, Ravichandran, M, Lautens, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC)
登録日2018-02-11
公開日2018-02-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors.
J. Med. Chem., 61, 2018
6QMN
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BU of 6qmn by Molmil
Crystal structure of a Ribonuclease A-Onconase chimera
分子名称: PHOSPHATE ION, Ribonuclease pancreatic
著者Esposito, L, Vitagliano, L, Ruggiero, A, Picone, D, Leone, S, Donnarumma, F.
登録日2019-02-07
公開日2019-05-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structure, stability and aggregation propensity of a Ribonuclease A-Onconase chimera.
Int.J.Biol.Macromol., 133, 2019
6RP5
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BU of 6rp5 by Molmil
Crystal structure of monocarboxylated hemoglobin from the sub-Antarctic fish Eleginops maclovinus
分子名称: CARBON MONOXIDE, DITHIONITE, Hemoglobin subunit alpha 1, ...
著者Balasco, N, Vitagliano, L, Merlino, A, Verde, C, Mazzarella, L, Vergara, A.
登録日2019-05-13
公開日2019-12-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献The unique structural features of carbonmonoxy hemoglobin from the sub-Antarctic fish Eleginops maclovinus.
Sci Rep, 9, 2019
2H8D
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BU of 2h8d by Molmil
Crystal structure of deoxy hemoglobin from Trematomus bernacchii at pH 8.4
分子名称: Hemoglobin alpha subunit, Hemoglobin beta subunit, POTASSIUM ION, ...
著者Mazzarella, L, Vergara, A, Vitagliano, L, Merlino, A, Bonomi, G, Scala, S, Verde, C, di Prisco, G.
登録日2006-06-07
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect.
Proteins, 65, 2006
2H8F
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BU of 2h8f by Molmil
Crystal structure of deoxy hemoglobin from Trematomus bernacchii at pH 6.2
分子名称: Hemoglobin alpha subunit, Hemoglobin beta subunit, PROTOPORPHYRIN IX CONTAINING FE
著者Mazzarella, L, Vergara, A, Vitagliano, L, Merlino, A, Bonomi, G, Scala, S, Verde, C, di Prisco, G.
登録日2006-06-07
公開日2006-08-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect.
Proteins, 65, 2006
6H1Y
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CRYSTAL STRUCTURE OF A CHIMERIC VARIANT OF THIOREDOXIN FROM ESCHERICHIA COLI
分子名称: Thioredoxin 1,Thioredoxin (TrxA-1),Thioredoxin 1
著者Ruggiero, A, Smaldone, G, Esposito, L, Balasco, N, Vitagliano, L.
登録日2018-07-12
公開日2019-02-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Loop size optimization induces a strong thermal stabilization of the thioredoxin fold.
Febs J., 286, 2019

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