8JJ3
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![BU of 8jj3 by Molmil](/molmil-images/mine/8jj3) | Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 2.5 | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHLORIDE ION, Proton-gated ion channel | 著者 | Bharambe, N, Li, Z, Basak, S. | 登録日 | 2023-05-29 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.6476 Å) | 主引用文献 | Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nat Commun, 15, 2024
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8I3Q
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7YFV
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![BU of 7yfv by Molmil](/molmil-images/mine/7yfv) | Structure of Rpgrip1l CC1 | 分子名称: | Protein fantom | 著者 | He, R, Chen, G, Li, Z, Li, J. | 登録日 | 2022-07-09 | 公開日 | 2023-05-17 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the N-terminal coiled-coil domains of the ciliary protein Rpgrip1l. Iscience, 26, 2023
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7YFU
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![BU of 7yfu by Molmil](/molmil-images/mine/7yfu) | Structure of Rpgrip1l CC2 | 分子名称: | Protein fantom | 著者 | He, R, Chen, G, Li, Z, Li, J. | 登録日 | 2022-07-09 | 公開日 | 2023-05-17 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of the N-terminal coiled-coil domains of the ciliary protein Rpgrip1l. Iscience, 26, 2023
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4NM6
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![BU of 4nm6 by Molmil](/molmil-images/mine/4nm6) | Crystal structure of TET2-DNA complex | 分子名称: | 5'-D(*AP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*T)-3', FE (II) ION, Methylcytosine dioxygenase TET2, ... | 著者 | Hu, L, Li, Z, Cheng, J, Rao, Q, Gong, W, Liu, M, Wang, P, Xu, Y. | 登録日 | 2013-11-14 | 公開日 | 2013-12-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.026 Å) | 主引用文献 | Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation. Cell(Cambridge,Mass.), 155, 2013
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5HXD
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![BU of 5hxd by Molmil](/molmil-images/mine/5hxd) | Crystal structure of murein-tripeptide amidase MpaA from Escherichia coli O157 | 分子名称: | CACODYLATE ION, Protein MpaA, ZINC ION | 著者 | Ma, Y, Bai, G, Zhang, X, Zhao, J, Yuan, Z, Kang, X, Li, Z, Mu, S, Liu, X. | 登録日 | 2016-01-30 | 公開日 | 2017-02-08 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of Murein-Tripeptide Amidase MpaA from Escherichia coli O157 at 2.6 angstrom Resolution Protein Pept.Lett., 24, 2017
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6J8E
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![BU of 6j8e by Molmil](/molmil-images/mine/6j8e) | Human Nav1.2-beta2-KIIIA ternary complex | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Pan, X, Li, Z, Huang, X, Huang, G, Yan, N. | 登録日 | 2019-01-18 | 公開日 | 2019-02-27 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Molecular basis for pore blockade of human Na+channel Nav1.2 by the mu-conotoxin KIIIA. Science, 363, 2019
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7DTD
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![BU of 7dtd by Molmil](/molmil-images/mine/7dtd) | Voltage-gated sodium channel Nav1.1 and beta4 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 1 subunit alpha, ... | 著者 | Yan, N, Pan, X, Li, Z, Huang, G. | 登録日 | 2021-01-04 | 公開日 | 2021-04-07 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Comparative structural analysis of human Na v 1.1 and Na v 1.5 reveals mutational hotspots for sodium channelopathies. Proc.Natl.Acad.Sci.USA, 118, 2021
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7VME
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![BU of 7vme by Molmil](/molmil-images/mine/7vme) | Crystal structure of a hydrolase in apo form 2 | 分子名称: | CALCIUM ION, hydrolase | 著者 | Wu, P, Zhao, Y.P, Li, Z.S, Ingrid, M.C, Lara, P, Gao, J, Han, X, Li, Q, Basak, O, Liu, W.D, Wei, R. | 登録日 | 2021-10-08 | 公開日 | 2022-10-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Crystal structure of a hydrolase in apo form 2 to be published
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6KL9
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![BU of 6kl9 by Molmil](/molmil-images/mine/6kl9) | Structure of LbCas12a-crRNA complex bound to AcrVA4 (form A complex) | 分子名称: | AcrVA4, LbCas12a, MAGNESIUM ION, ... | 著者 | Peng, R, Li, Z, Xu, Y, He, S, Peng, Q, Shi, Y, Gao, G.F. | 登録日 | 2019-07-30 | 公開日 | 2019-09-11 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4. Proc.Natl.Acad.Sci.USA, 116, 2019
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5XGP
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8I41
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8I42
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8I48
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![BU of 8i48 by Molmil](/molmil-images/mine/8i48) | Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in closed state | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHLORIDE ION, Proton-gated ion channel | 著者 | Bharambe, N, Li, Z, Basak, S. | 登録日 | 2023-01-18 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nat Commun, 15, 2024
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8I47
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7W16
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![BU of 7w16 by Molmil](/molmil-images/mine/7w16) | Complex structure of alginate lyase AlyV with M8 | 分子名称: | GLYCEROL, alginate lyase, beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid | 著者 | Liu, W.Z, Lyu, Q.Q, Li, Z.J, Zhang, K.K. | 登録日 | 2021-11-19 | 公開日 | 2022-08-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Determination of oligosaccharide product distributions of PL7 alginate lyases by their structural elements. Commun Biol, 5, 2022
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7W13
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![BU of 7w13 by Molmil](/molmil-images/mine/7w13) | Complex structure of alginate lyase PyAly with M8 | 分子名称: | Alginate lyase, beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid | 著者 | Liu, W.Z, Lyu, Q.Q, Li, Z.J, Zhang, K.K. | 登録日 | 2021-11-19 | 公開日 | 2022-08-17 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Determination of oligosaccharide product distributions of PL7 alginate lyases by their structural elements. Commun Biol, 5, 2022
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5YBZ
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5X0M
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![BU of 5x0m by Molmil](/molmil-images/mine/5x0m) | Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, ... | 著者 | Shen, H, Zhou, Q, Pan, X, Li, Z, Wu, J, Yan, N. | 登録日 | 2017-01-21 | 公開日 | 2017-03-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355, 2017
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7VTV
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![BU of 7vtv by Molmil](/molmil-images/mine/7vtv) | Crystal structure of PDE8A catalytic domain in complex with 15 | 分子名称: | 2-chloro-9-(3-(2,2-difluoroethoxy)-5-(difluoromethoxy)benzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B. | 登録日 | 2021-10-31 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia To Be Published
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7VTX
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![BU of 7vtx by Molmil](/molmil-images/mine/7vtx) | Crystal structure of PDE8A catalytic domain in complex with 22 | 分子名称: | 2-chloro-9-(3-(2,2-difluoroethoxy)-5-(pyridin-4-yl)benzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B. | 登録日 | 2021-10-31 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.50010943 Å) | 主引用文献 | Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia To Be Published
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7VSL
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![BU of 7vsl by Molmil](/molmil-images/mine/7vsl) | Crystal structure of PDE8A catalytic domain in complex with 10 | 分子名称: | 2-chloro-9-(3-(2,2-difluoroethoxy)benzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B. | 登録日 | 2021-10-26 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.500069 Å) | 主引用文献 | Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia To Be Published
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7VTW
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![BU of 7vtw by Molmil](/molmil-images/mine/7vtw) | Crystal structure of PDE8A catalytic domain in complex with 17 | 分子名称: | 2-chloro-9-(3-(2,2-difluoroethoxy)-5-isopropoxybenzyl)-9H-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Wu, X.-N, Zhou, Q, Huang, Y.-D, Li, Z, Wu, Y, Luo, H.-B. | 登録日 | 2021-10-31 | 公開日 | 2022-11-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.79971337 Å) | 主引用文献 | Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia To Be Published
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7X9Q
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![BU of 7x9q by Molmil](/molmil-images/mine/7x9q) | Crystal structure of human STING complexed with compound BSP16 | 分子名称: | (2R)-4-(5,6-dimethoxy-1-benzoselenophen-2-yl)-2-ethyl-4-oxidanylidene-butanoic acid, Stimulator of interferon genes protein | 著者 | Pan, L, Guan, X, Feng, X, Li, Z, Bian, J. | 登録日 | 2022-03-15 | 公開日 | 2022-09-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents. J.Med.Chem., 65, 2022
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8H10
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![BU of 8h10 by Molmil](/molmil-images/mine/8h10) | Structure of SARS-CoV-1 Spike Protein with Engineered x1 Disulfide (S370C and D967C), Locked-2 Conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | 著者 | Zhang, X, Li, Z, Liu, Y, Wang, J, Fu, L, Wang, P, He, J, Xiong, X. | 登録日 | 2022-09-30 | 公開日 | 2022-10-19 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Life Sci Alliance, 6, 2023
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