7VTX

Crystal structure of PDE8A catalytic domain in complex with 22

Summary for 7VTX

• Entry DOI: 10.2210/pdb7vtx/pdb
• Descriptor: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: camp-specific, hydrolase, selective pde8a inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 39596.55

Authors

Wu, X.-N.,Zhou, Q.,Huang, Y.-D.,Li, Z.,Wu, Y.,Luo, H.-B. (deposition date: 2021-10-31, release date: 2022-11-02, Last modification date: 2024-10-30)

• Primary citation: Wu, X.-N.,Zhou, Q.,Huang, Y.-D.,Li, Z.,Wu, Y.,Luo, H.-B.; Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.50010936848 Å)