6C9U
| Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) | Descriptor: | 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ... | Authors: | Deis, L.N, Li, X, Mathews, I.I, Khosla, C. | Deposit date: | 2018-01-28 | Release date: | 2018-05-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. J. Am. Chem. Soc., 140, 2018
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5ZLA
| Crystal structure of mutant C387A of DFA-IIIase from Arthrobacter chlorophenolicus A6 in complex with DFA-III | Descriptor: | (2R,3'S,4'S,4aR,5'R,6R,7R,7aS)-4a,5',6-tris(hydroxymethyl)spiro[3,6,7,7a-tetrahydrofuro[2,3-b][1,4]dioxine-2,2'-oxolane ]-3',4',7-triol, DFA-IIIase C387A mutant | Authors: | Yu, S.H, Shen, H, Li, X, Mu, W.M. | Deposit date: | 2018-03-27 | Release date: | 2018-12-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue Acs Catalysis, 8, 2018
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2OQI
| Human Dipeptidyl Peptidase IV (DPP4) with Piperidinone-constrained phenethylamine | Descriptor: | (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE, Dipeptidyl peptidase 4 (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (Adenosine deaminase complexing protein 2) (ADABP) | Authors: | Pei, Z, Li, X, von Geldern, T.W, Longenecker, K.L, Pireh, D, Stewart, K.D, Backes, B.J, Lai, C, Lubben, T.H, Ballaron, S.J, Beno, D.W, Kempf-Grote, A.J, Sham, H.L, Trevillyan, J.M. | Deposit date: | 2007-01-31 | Release date: | 2007-04-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery and Structure-Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors. J.Med.Chem., 50, 2007
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2OQV
| Human Dipeptidyl Peptidase IV (DPP4) with piperidine-constrained phenethylamine | Descriptor: | (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE, Dipeptidyl peptidase 4 (Dipeptidyl peptidase IV) (DPP IV) | Authors: | Pei, Z, Li, X, von Geldern, T.W, Longenecker, K.L, Pireh, D, Stewart, K.D. | Deposit date: | 2007-02-01 | Release date: | 2007-04-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery and Structure-Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors. J.Med.Chem., 50, 2007
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7XLT
| Cryo-EM Structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids | Descriptor: | DNA, RNA, S9.6 Fab HC, ... | Authors: | Li, Q, Lin, C, Luo, Z, Li, H, Li, X, Sun, Q. | Deposit date: | 2022-04-22 | Release date: | 2022-05-25 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids. J Genet Genomics, 49, 2022
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2FBS
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6LQI
| Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1 | Descriptor: | Piezo-type mechanosensitive ion channel component 1 | Authors: | Geng, J, Liu, W, Zhou, H, Zhang, T, Wang, L, Zhang, M, Shen, B, Li, X, Xiao, B. | Deposit date: | 2020-01-13 | Release date: | 2020-03-04 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel. Neuron, 106, 2020
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2F3A
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2H0P
| NMR Structure of the Dengue-4 virus Envelope Protein Domain III | Descriptor: | Envelope glycoprotein | Authors: | Volk, D.E, Lee, Y, Li, X, Thiviyanathan, V, Barrett, A.D.T, Gorenstein, D.G. | Deposit date: | 2006-05-15 | Release date: | 2007-03-27 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Solution structure of the envelope protein domain III of dengue-4 virus. Virology, 364, 2007
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2FBU
| Solution structure of the N-terminal fragment of human LL-37 | Descriptor: | Antibacterial protein FALL-39, core peptide | Authors: | Wang, G, Li, X. | Deposit date: | 2005-12-10 | Release date: | 2006-05-23 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region J.Am.Chem.Soc., 128, 2006
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2FCG
| Solution structure of the C-terminal fragment of human LL-37 | Descriptor: | Antibacterial protein FALL-39, core peptide | Authors: | Wang, G, Li, X. | Deposit date: | 2005-12-12 | Release date: | 2006-05-23 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution Structures of Human LL-37 Fragments and NMR-Based Identification of a Minimal Membrane-Targeting Antimicrobial and Anticancer Region. J.Am.Chem.Soc., 128, 2006
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7C4U
| MicroED structure of orthorhombic Vancomycin at 1.2 A resolution | Descriptor: | CHLORIDE ION, Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose | Authors: | Fan, Q, Zhou, H, Li, X, Wang, J. | Deposit date: | 2020-05-18 | Release date: | 2020-08-12 | Last modified: | 2021-03-17 | Method: | ELECTRON CRYSTALLOGRAPHY (1.2 Å) | Cite: | Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms. Angew.Chem.Int.Ed.Engl., 59, 2020
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7C4V
| MicroED structure of anorthic Vancomycin at 1.05 A resolution | Descriptor: | CHLORIDE ION, Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose | Authors: | Fan, Q, Zhou, H, Li, X, Wang, J. | Deposit date: | 2020-05-18 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | Cite: | Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms. Angew.Chem.Int.Ed.Engl., 59, 2020
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6KNM
| Apelin receptor in complex with single domain antibody | Descriptor: | Apelin receptor,Rubredoxin,Apelin receptor, Single domain antibody JN241, ZINC ION | Authors: | Ma, Y.B, Ding, Y, Song, X, Ma, X, Li, X, Zhang, N, Song, Y, Sun, Y, Shen, Y, Zhong, W, Hu, L.A, Ma, Y.L, Zhang, M.Y. | Deposit date: | 2019-08-06 | Release date: | 2020-01-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure-guided discovery of a single-domain antibody agonist against human apelin receptor. Sci Adv, 6, 2020
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8IZB
| Lysophosphatidylserine receptor GPR174-Gs complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Gong, W, Liu, G, Li, X, Zhang, X. | Deposit date: | 2023-04-06 | Release date: | 2023-11-01 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174. Plos Biol., 21, 2023
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8TWU
| Crystal structure of Cytochrome P450 AspB bound to N1-methylated cyclo-L-Trp-L-Pro | Descriptor: | (3S,5S,8aS)-3-[(1-methyl-1H-indol-3-yl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, Cytochrome P450 AspB, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Gering, H.E, Li, X, Tang, H, Swartz, P.D, Chang, W.-C, Makris, T.M. | Deposit date: | 2023-08-21 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization. J.Am.Chem.Soc., 145, 2023
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8IZ4
| Lysophosphatidylserine receptor GPR34-Gi complex | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Gong, W, Liu, G, Li, X, Zhang, X. | Deposit date: | 2023-04-06 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural mechanisms of ligand binding and signaling in lysophosphatidylserine receptors To Be Published
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8JC0
| V gamma9 V delta2 TCR and CD3 complex in LMNG | Descriptor: | CHOLESTEROL, T cell receptor delta variable 2,T cell receptor delta constant, T cell receptor gamma variable 9,T cell receptor gamma constant 1, ... | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | Deposit date: | 2023-05-10 | Release date: | 2024-05-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
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8JCB
| Vgamma5 Vdelta1 T cell receptor complex | Descriptor: | T cell receptor delta variable 1,T cell receptor delta constant, T cell receptor gamma variable 5,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | Authors: | Xin, W, Huang, B, Chi, X, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | Deposit date: | 2023-05-10 | Release date: | 2024-05-08 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (9.5 Å) | Cite: | Structures of human gamma delta T cell receptor-CD3 complex. Nature, 630, 2024
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8JWE
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6JIR
| Crystal structure of C. crescentus beta sliding clamp with PEG bound to putative beta-motif tethering region | Descriptor: | 1,2-ETHANEDIOL, Beta sliding clamp, DI(HYDROXYETHYL)ETHER, ... | Authors: | Jiang, X, Teng, M, Li, X. | Deposit date: | 2019-02-23 | Release date: | 2019-11-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Caulobacter crescentus beta sliding clamp employs a noncanonical regulatory model of DNA replication. Febs J., 287, 2020
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8J00
| Human KCNQ2-CaM in complex with CBD | Descriptor: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, cannabidiol | Authors: | Ma, D, Li, X, Guo, J. | Deposit date: | 2023-04-09 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8IZY
| Human KCNQ2-CaM in complex with HN37 | Descriptor: | Potassium voltage-gated channel subfamily KQT member 2, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate | Authors: | Ma, D, Li, X, Guo, J. | Deposit date: | 2023-04-09 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8J02
| Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II | Descriptor: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | Authors: | Ma, D, Li, X, Guo, J. | Deposit date: | 2023-04-09 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8J05
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