4R3M
| Crystal structure of Human Hsp90 with JR9 | Descriptor: | Heat shock protein HSP 90-alpha, N~3~-benzyl-2-[(6-bromo-1,3-benzodioxol-5-yl)methyl]imidazo[1,2-a]pyrazine-3,8-diamine | Authors: | Li, J, Yang, M, Ren, J, Xiong, B, He, J. | Deposit date: | 2014-08-16 | Release date: | 2014-11-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity. Org.Biomol.Chem., 13, 2015
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5F3X
| Crystal structure of Harmonin NPDZ1 in complex with ANKS4B SAM-PBM | Descriptor: | Ankyrin repeat and SAM domain-containing protein 4B, CHLORIDE ION, Harmonin | Authors: | Li, J, He, Y, Lu, Q, Zhang, M. | Deposit date: | 2015-12-03 | Release date: | 2016-03-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.649 Å) | Cite: | Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex Dev.Cell, 36, 2016
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6DQ3
| Streptococcus pyogenes deacetylase PplD in complex with acetate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, IMIDAZOLE, ... | Authors: | Li, J, Korotkova, N, Korotkov, K.V. | Deposit date: | 2018-06-10 | Release date: | 2019-05-01 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides Nat Commun, 13, 2022
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3LCA
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1COY
| CRYSTAL STRUCTURE OF CHOLESTEROL OXIDASE COMPLEXED WITH A STEROID SUBSTRATE. IMPLICATIONS FOR FAD DEPENDENT ALCOHOL OXIDASES | Descriptor: | 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, CHOLESTEROL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Li, J, Vrielink, A, Brick, P, Blow, D.M. | Deposit date: | 1993-06-14 | Release date: | 1993-10-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases. Biochemistry, 32, 1993
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4JN9
| Crystal structure of the DepH | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DepH, ... | Authors: | Li, J, Wang, C, Zhang, Z.M, Zhou, J.H, Cheng, E. | Deposit date: | 2013-03-14 | Release date: | 2014-04-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci Rep, 4, 2014
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2JOM
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4JNA
| Crystal structure of the DepH complex with dimethyl-FK228 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DepH, ... | Authors: | Li, J, Wang, C, Zhang, Z.M, Zhou, J.H, Cheng, E. | Deposit date: | 2013-03-14 | Release date: | 2014-03-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci Rep, 4, 2014
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4L93
| Crystal structure of Human Hsp90 with S36 | Descriptor: | 3,4-dihydroisoquinolin-2(1H)-yl[2,4-dihydroxy-5-(propan-2-yl)phenyl]methanone, Heat shock protein HSP 90-alpha | Authors: | Li, J, Ren, J, Yang, M, Xiong, B, He, J. | Deposit date: | 2013-06-18 | Release date: | 2014-06-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.845 Å) | Cite: | Crystal structure of Human Hsp90 with S36 To be Published
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4L90
| Crystal structure of Human Hsp90 with RL3 | Descriptor: | Heat shock protein HSP 90-alpha, [5-(6-bromo[1,2,4]triazolo[4,3-a]pyridin-3-yl)-2,4-dihydroxyphenyl](4-methylpiperazin-1-yl)methanone | Authors: | Li, J, Ren, J, Yang, M, Xiong, B, He, J. | Deposit date: | 2013-06-18 | Release date: | 2014-06-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Crystal structure of Human Hsp90 with RL3 to be published
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4QQF
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5ZMZ
| Amyloid core of RIP1 | Descriptor: | Amyloid core of RIP1 | Authors: | Li, J.X, Zheng, J. | Deposit date: | 2018-04-06 | Release date: | 2019-04-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Amyloid core of RIP1 To Be Published
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5XQE
| Crystal structure of Human Hsp90 with FS3 | Descriptor: | Heat shock protein HSP 90-alpha, N-[3-[5-chloranyl-2,4-bis(oxidanyl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]-2-methyl-propanamide | Authors: | Li, J, Shi, F, Xiong, B, He, J.H. | Deposit date: | 2017-06-07 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Crystal structure of Human Hsp90 with FS3 To Be Published
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5XRD
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5XRE
| Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor JX1 | Descriptor: | Heat shock protein HSP 90-alpha, N-[4-(4-methoxyphenyl)-3-[5-(8-methylquinolin-5-yl)-2,4-bis(oxidanyl)phenyl]-1,2-oxazol-5-yl]ethanamide | Authors: | Li, J, Shi, F, Xiong, B, He, J.H. | Deposit date: | 2017-06-08 | Release date: | 2018-07-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.497 Å) | Cite: | Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor JX1 To Be Published
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5XR9
| Crystal structure of Human Hsp90 with FS6 | Descriptor: | Heat shock protein HSP 90-alpha, N-[3-[5-bromanyl-2,4-bis(oxidanyl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]ethanamide | Authors: | Li, J, Shi, F, Xiong, B, He, J.H. | Deposit date: | 2017-06-08 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Crystal structure of Human Hsp90 with FS6 To Be Published
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5XQD
| Crystal structure of Human Hsp90 with FS2 | Descriptor: | Heat shock protein HSP 90-alpha, N-[3-[5-chloranyl-2,4-bis(oxidanyl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]propanamide | Authors: | Li, J, Shi, F, Xiong, B, He, J.H. | Deposit date: | 2017-06-07 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of Human Hsp90 with FS2 To Be Published
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5XR5
| Crystal structure of Human Hsp90 with FS4 | Descriptor: | Heat shock protein HSP 90-alpha, N-[3-[5-chloranyl-2,4-bis(oxidanyl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]-2,2-dimethyl-propanamide | Authors: | Li, J, Shi, F, Xiong, B, He, J.H. | Deposit date: | 2017-06-07 | Release date: | 2018-06-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of Human Hsp90 with FS4 To Be Published
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5XRB
| Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 | Descriptor: | Heat shock protein HSP 90-alpha, N-[3-[5-chloranyl-2,4-bis(oxidanyl)phenyl]-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]cyclopropanecarboxamide | Authors: | Li, J, Shi, F, Xiong, B, He, J.H. | Deposit date: | 2017-06-08 | Release date: | 2018-07-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ5 To Be Published
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4O7P
| Crystal structure of Mycobacterium tuberculosis maltose kinase MaK complexed with maltose | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Maltokinase, SULFATE ION, ... | Authors: | Li, J, Guan, X.T, Rao, Z.H. | Deposit date: | 2013-12-26 | Release date: | 2014-10-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Homotypic dimerization of a maltose kinase for molecular scaffolding. Sci Rep, 4, 2014
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7FIX
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8FLM
| Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53 | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, ... | Authors: | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | Deposit date: | 2022-12-21 | Release date: | 2023-11-01 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
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4O7O
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8UOZ
| EmrE structure in the TPP-bound state (WT/E14Q heterodimer) | Descriptor: | SMR family multidrug efflux protein EmrE, TETRAPHENYLPHOSPHONIUM | Authors: | Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. | Deposit date: | 2023-10-20 | Release date: | 2024-05-29 | Method: | SOLID-STATE NMR, SOLUTION NMR | Cite: | Molecular Basis of Drug Recognition by EmrE To Be Published
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8UWU
| EmrE structure in the proton-bound state (WT/L51I heterodimer) | Descriptor: | SMR family multidrug efflux protein EmrE | Authors: | Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. | Deposit date: | 2023-11-08 | Release date: | 2024-05-29 | Method: | SOLID-STATE NMR, SOLUTION NMR | Cite: | Molecular Basis of Drug Recognition by EmrE To Be Published
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