8E1X
 
 | | FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29) | | 分子名称: | (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide, Fibroblast growth factor receptor 2 | | 著者 | Lei, H.-T, Epling, L.B, Deller, M.C. | | 登録日 | 2022-08-11 | | 公開日 | 2022-11-23 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
J.Med.Chem., 65, 2022
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6XNK
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7KGV
 | | Crystal structure of sodium-coupled neutral amino acid transporter SLC38A9 in the N-terminal plugged form | | 分子名称: | Monoclonal antibody Fab heavy chain, Monoclonal antibody Fab light chain, Sodium-coupled neutral amino acid transporter 9 | | 著者 | Lei, H, Mu, X, Hattne, J, Gonen, T. | | 登録日 | 2020-10-19 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | A conformational change in the N terminus of SLC38A9 signals mTORC1 activation.
Structure, 29, 2021
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4YIW
 | | DIHYDROOROTASE FROM BACILLUS ANTHRACIS WITH SUBSTRATE BOUND | | 分子名称: | Dihydroorotase, N-CARBAMOYL-L-ASPARTATE, ZINC ION | | 著者 | Lei, H, Santarsiero, B.D, Rice, A.J, Lee, H, Johnson, M.E. | | 登録日 | 2015-03-02 | | 公開日 | 2016-08-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase).
Bioorg.Med.Chem., 24, 2016
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4PT5
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4RNA
 | | Crystal structure of PLpro from Middle East Respiratory Syndrome (MERS) coronavirus | | 分子名称: | PHOSPHATE ION, ZINC ION, papain-like protease | | 著者 | Lei, H, Santarsiero, B.D, Lee, H, Johnson, M.E. | | 登録日 | 2014-10-23 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.794 Å) | | 主引用文献 | Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV.
Acs Chem.Biol., 10, 2015
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7MRI
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6C08
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3QPS
 | | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni | | 分子名称: | CHOLIC ACID, CmeR | | 著者 | Lei, H.T, Routh, M.D, Shen, Z, Su, C.C, Zhang, Q, Yu, E.W. | | 登録日 | 2011-02-14 | | 公開日 | 2011-03-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.351 Å) | | 主引用文献 | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni.
Protein Sci., 20, 2011
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3QQA
 | | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni | | 分子名称: | CmeR, TAUROCHOLIC ACID | | 著者 | Lei, H.T, Routh, M.D, Shen, Z, Su, C.-C, Zhang, Q, Yu, E.W. | | 登録日 | 2011-02-15 | | 公開日 | 2011-03-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni.
Protein Sci., 20, 2011
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6DUJ
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2BY6
 | | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | | 分子名称: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | | 著者 | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | | 登録日 | 2005-07-29 | | 公開日 | 2006-02-06 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection?
Acta Crystallogr.,Sect.D, 62, 2006
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2BY9
 | | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | | 分子名称: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | | 著者 | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | | 登録日 | 2005-07-29 | | 公開日 | 2006-02-06 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection?
Acta Crystallogr.,Sect.D, 62, 2006
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2BY7
 | | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | | 分子名称: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | | 著者 | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | | 登録日 | 2005-07-29 | | 公開日 | 2006-02-06 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection?
Acta Crystallogr.,Sect.D, 62, 2006
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2BY5
 | | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | | 分子名称: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | | 著者 | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | | 登録日 | 2005-07-29 | | 公開日 | 2006-02-06 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection?
Acta Crystallogr.,Sect.D, 62, 2006
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2BY8
 | | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | | 分子名称: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | | 著者 | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | | 登録日 | 2005-07-29 | | 公開日 | 2006-02-06 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection?
Acta Crystallogr.,Sect.D, 62, 2006
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2BYA
 | | Is radiation damage dependent on the dose-rate used during macromolecular crystallography data collection | | 分子名称: | BENZAMIDINE, CALCIUM ION, CATIONIC TRYPSIN, ... | | 著者 | Leiros, H.-K.S, Timmins, J, Ravelli, R.B.G, McSweeney, S.M. | | 登録日 | 2005-07-29 | | 公開日 | 2006-02-06 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Is Radiation Damage Dependent on the Dose-Rate Used During Macromolecular Crystallography Data Collection?
Acta Crystallogr.,Sect.D, 62, 2006
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4UWP
 | | Penta Zn1 coordination. Leu224 in VIM-26 from Klebsiella pneumoniae has implications for drug binding. | | 分子名称: | METALLO-BETA-LACTAMASE VIM-26, ZINC ION | | 著者 | Leiros, H.-K.S, Edvardsen, K.S.W, Bjerga, G.E.K, Samuelsen, O. | | 登録日 | 2014-08-14 | | 公開日 | 2015-02-04 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and Biochemical Characterization of Vim-26 Show that Leu224 Has Implications for the Substrate Specificity of Vim Metallo-Beta-Lactamases.
FEBS J., 282, 2015
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4UWS
 | | VIM-26-PEG. Leu224 in VIM-26 from Klebsiella pneumoniae has implications for drug binding. | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, METALLO-BETA-LACTAMASE VIM-26, ... | | 著者 | Leiros, H.-K.S, Edvardsen, K.S.W, Bjerga, G.E.K, Samuelsen, O. | | 登録日 | 2014-08-14 | | 公開日 | 2015-02-04 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Structural and Biochemical Characterization of Vim-26 Show that Leu224 Has Implications for the Substrate Specificity of Vim Metallo-Beta-Lactamases.
FEBS J., 282, 2015
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1UTN
 | | Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZYLAMINE, CALCIUM ION, ... | | 著者 | Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. | | 登録日 | 2003-12-09 | | 公開日 | 2004-01-09 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
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1UTO
 | | Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements | | 分子名称: | 2-PHENYLETHYLAMINE, CALCIUM ION, GLYCEROL, ... | | 著者 | Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. | | 登録日 | 2003-12-09 | | 公開日 | 2004-01-15 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
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1UTQ
 | | Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements | | 分子名称: | CALCIUM ION, GLYCEROL, TRYPSINOGEN | | 著者 | Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. | | 登録日 | 2003-12-09 | | 公開日 | 2004-01-15 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
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1UTP
 | | Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements | | 分子名称: | 4-PHENYLBUTYLAMINE, CALCIUM ION, GLYCEROL, ... | | 著者 | Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. | | 登録日 | 2003-12-09 | | 公開日 | 2004-01-15 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
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4AOU
 | | CtIDH bound to NADP. The complex structures of Isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila, support a new active site locking mechanism | | 分子名称: | ISOCITRATE DEHYDROGENASE [NADP], ISOCITRIC ACID, MAGNESIUM ION, ... | | 著者 | Leiros, H.-K.S, Fedoy, A.-E, Leiros, I, Steen, I.H. | | 登録日 | 2012-03-30 | | 公開日 | 2012-07-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila suggest a new active site locking mechanism.
Febs Open Bio, 2, 2012
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1UTM
 | | Trypsin specificity as elucidated by LIE calculations, X-ray structures and association constant measurements | | 分子名称: | 2-PHENYLETHYLAMINE, CALCIUM ION, TRYPSIN I | | 著者 | Leiros, H.-K.S, Brandsdal, B.O, Andersen, O.A, Os, V, Leiros, I, Helland, R, Otlewski, J, Willassen, N.P, Smalas, A.O. | | 登録日 | 2003-12-09 | | 公開日 | 2004-01-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Trypsin Specificity as Elucidated by Lie Calculations, X-Ray Structures, and Association Constant Measurements
Protein Sci., 13, 2004
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