3Q4F
 
 | | Crystal structure of xrcc4/xlf-cernunnos complex | | Descriptor: | DNA repair protein XRCC4, Non-homologous end-joining factor 1 | | Authors: | Ropars, V, Legrand, P, Charbonnier, J.B. | | Deposit date: | 2010-12-23 | | Release date: | 2011-08-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (5.5 Å) | | Cite: | Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining.
Proc.Natl.Acad.Sci.USA, 108, 2011
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5AMS
 | | Crystal structure of Sqt1 | | Descriptor: | RIBOSOME ASSEMBLY PROTEIN SQT1 | | Authors: | Frenois, F, Legrand, P, Fribourg, S. | | Deposit date: | 2015-08-31 | | Release date: | 2016-01-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Sqt1P is an Eight-Bladed Wd40 Protein
Acta Crystallogr.,Sect.F, 72, 2016
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4FMN
 | | Structure of the C-terminal domain of the Saccharomyces cerevisiae MUTL alpha (MLH1/PMS1) heterodimer bound to a fragment of NTG2 | | Descriptor: | 1,2-ETHANEDIOL, DNA mismatch repair protein MLH1, DNA mismatch repair protein PMS1, ... | | Authors: | Gueneau, E, Legrand, P, Charbonnier, J.B. | | Deposit date: | 2012-06-18 | | Release date: | 2013-02-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Structure of the MutL alpha C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.
Nat.Struct.Mol.Biol., 20, 2013
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8A50
 | | Crystal structure of HSF2BP-ALPHA1 tetramer | | Descriptor: | Heat shock factor 2-binding protein, PHOSPHATE ION | | Authors: | Miron, S, Legrand, P, Ropars, V, Ghouil, R, Zinn-Justin, S. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-05 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.484 Å) | | Cite: | BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination.
Sci Adv, 9, 2023
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1Q5M
 | | Binary complex of rabbit 20alpha-hydroxysteroid dehydrogenase with NADPH | | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION | | Authors: | Couture, J.F, Legrand, P, Cantin, L, Labrie, F, Luu-The, V, Breton, R. | | Deposit date: | 2003-08-08 | | Release date: | 2004-05-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | Loop Relaxation, A Mechanism that Explains the Reduced Specificity of Rabbit 20alpha-Hydroxysteroid Dehydrogenase, A Member of the Aldo-Keto Reductase Superfamily.
J.Mol.Biol., 339, 2004
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7QBS
 | | B12-dependent radical SAM methyltransferase, Mmp10 with [4Fe-4S] cluster, cobalamin, S-adenosyl-L-methionine, and peptide bound. | | Descriptor: | CO-METHYLCOBALAMIN, FE (III) ION, IRON/SULFUR CLUSTER, ... | | Authors: | Bernardo-Garcia, N, Fyfe, C.D, Chavas, L.M.G, Legrand, P, Benjdia, A, Berteau, O. | | Deposit date: | 2021-11-19 | | Release date: | 2022-02-02 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (2.327 Å) | | Cite: | Crystallographic snapshots of a B 12 -dependent radical SAM methyltransferase.
Nature, 602, 2022
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1OAO
 | | NiZn[Fe4S4] and NiNi[Fe4S4] clusters in closed and open alpha subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase | | Descriptor: | ACETATE ION, BICARBONATE ION, CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE SUBUNIT ALPHA, ... | | Authors: | Darnault, C, Volbeda, A, Kim, E.J, Legrand, P, Vernede, X, Lindahl, P.A, Fontecilla-Camps, J.C. | | Deposit date: | 2003-01-20 | | Release date: | 2003-04-11 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] Clusters in Closed and Open Alpha Subunits of Acetyl-Coa Synthase/Carbon Monoxide Dehydrogenase
Nat.Struct.Biol., 10, 2003
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1Q13
 | | Crystal structure of rabbit 20alpha hyroxysteroid dehydrogenase in ternary complex with NADP and testosterone | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin-E2 9-reductase, SULFATE ION, ... | | Authors: | Couture, J.-F, Cantin, L, Legrand, P, Luu-The, V, Labrie, F, Breton, R. | | Deposit date: | 2003-07-18 | | Release date: | 2004-11-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily.
J. Mol. Biol., 339, 2004
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7QZO
 | | Crystal structure of GacS D1 domain | | Descriptor: | CADMIUM ION, GLYCEROL, Histidine kinase | | Authors: | Fadel, F, Bassim, V, Botzanowski, T, Francis, V.I, Legrand, P, Porter, S.L, Bourne, Y, Cianferani, S, Vincent, F. | | Deposit date: | 2022-01-31 | | Release date: | 2022-07-06 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS.
Structure, 30, 2022
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7QZ2
 | | Crystal structure of GacS D1 domain in complex with BeF3- | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, CADMIUM ION, Histidine kinase, ... | | Authors: | Fadel, F, Bassim, V, Botzanowski, T, Francis, V.I, Legrand, P, Porter, S.L, Bourne, Y, Cianferani, S, Vincent, F. | | Deposit date: | 2022-01-30 | | Release date: | 2022-07-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS.
Structure, 30, 2022
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5OLL
 | | Crystal structure of gurmarin, a sweet taste suppressing polypeptide | | Descriptor: | Gurmarin, NICKEL (II) ION | | Authors: | Sigoillot, M, Neiers, F, Legrand, P, Roblin, P, Briand, L. | | Deposit date: | 2017-07-28 | | Release date: | 2018-08-08 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | The Crystal Structure of Gurmarin, a Sweet Taste-Suppressing Protein: Identification of the Amino Acid Residues Essential for Inhibition.
Chem. Senses, 43, 2018
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7Z21
 | | BAF A12T bound to the lamin A/C Ig-fold domain | | Descriptor: | Barrier-to-autointegration factor, N-terminally processed, CHLORIDE ION, ... | | Authors: | Marcelot, A, Legrand, P, Zinn-Justin, S. | | Deposit date: | 2022-02-25 | | Release date: | 2022-08-24 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.629 Å) | | Cite: | The BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor-Guillermo progeria syndrome cells.
Nucleic Acids Res., 50, 2022
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7Q5G
 | | LAN-DAP5 DERIVATIVE OF LANREOTIDE: L-DIAMINO PROPIONIC ACID IN POSITION 5 IN PLACE OF L-LYSINE | | Descriptor: | ETHANOL, LAN-DAP5 DERIVATIVE OF LANREOTIDE | | Authors: | Bressanelli, S, Le Du, M.H, Gobeaux, F, Legrand, P, Paternostre, M. | | Deposit date: | 2021-11-03 | | Release date: | 2022-02-02 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (0.83 Å) | | Cite: | Atomic structure of Lanreotide nanotubes revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 119, 2022
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4FMO
 | | Structure of the C-terminal domain of the Saccharomyces cerevisiae MUTL alpha (MLH1/PMS1) heterodimer bound to a fragment of exo1 | | Descriptor: | DNA mismatch repair protein MLH1, DNA mismatch repair protein PMS1, DNA repair peptide, ... | | Authors: | Gueneau, E, Legrand, P, Charbonnier, J.B. | | Deposit date: | 2012-06-18 | | Release date: | 2013-02-20 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.04 Å) | | Cite: | Structure of the MutL alpha C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.
Nat.Struct.Mol.Biol., 20, 2013
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6RMN
 | | DNA mismatch repair proteins MLH1 and MLH3 | | Descriptor: | DNA mismatch repair protein MLH1, DNA mismatch repair protein MLH3, ZINC ION | | Authors: | Dai, J, Chervy, P, Legrand, P, Ropars, V, Charbonnier, J.B. | | Deposit date: | 2019-05-07 | | Release date: | 2021-05-19 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formation.
Proc.Natl.Acad.Sci.USA, 118, 2021
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5LYV
 | | The crystal structure of 7SK 5'-hairpin - Osmium derivative | | Descriptor: | 7SK RNA, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Martinez-Zapien, D, Legrand, P, McEwen, A.G, Pasquali, S, Dock-Bregeon, A.-C. | | Deposit date: | 2016-09-28 | | Release date: | 2017-01-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | The crystal structure of the 5 functional domain of the transcription riboregulator 7SK.
Nucleic Acids Res., 45, 2017
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5LYU
 | | The native crystal structure of 7SK 5'-hairpin | | Descriptor: | 7SK RNA, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Martinez-Zapien, D, Legrand, P, McEwen, A.C, Pasquali, S, Dock-Bregeon, A.-C. | | Deposit date: | 2016-09-28 | | Release date: | 2017-01-25 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The crystal structure of the 5 functional domain of the transcription riboregulator 7SK.
Nucleic Acids Res., 45, 2017
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8A51
 | | Crystal structure of HSF2BP-BRME1 complex | | Descriptor: | 1,2-ETHANEDIOL, Break repair meiotic recombinase recruitment factor 1, CHLORIDE ION, ... | | Authors: | Miron, S, Legrand, P, Ropars, V, Ghouil, R, Zinn-Justin, S. | | Deposit date: | 2022-06-13 | | Release date: | 2023-07-05 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination.
Sci Adv, 9, 2023
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5LYS
 | | The crystal structure of 7SK 5'-hairpin - Gold derivative | | Descriptor: | 7SK RNA, GOLD ION, MAGNESIUM ION, ... | | Authors: | Martinez-Zapien, D, Legrand, P, McEwen, A.G, Pasquali, S, Dock-Bregeon, A.-C. | | Deposit date: | 2016-09-28 | | Release date: | 2017-01-25 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | The crystal structure of the 5 functional domain of the transcription riboregulator 7SK.
Nucleic Acids Res., 45, 2017
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4E4W
 | | Structure of the C-terminal domain of the Saccharomyces cerevisiae MUTL alpha (MLH1/PMS1) heterodimer | | Descriptor: | 1,2-ETHANEDIOL, DNA mismatch repair protein MLH1, DNA mismatch repair protein PMS1, ... | | Authors: | Gueneau, E, Legrand, P, Charbonnier, J.B. | | Deposit date: | 2012-03-13 | | Release date: | 2013-02-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the MutLalpha C-terminal domain reveals how Mlh1 contributes to Pms1 endonuclease site.
Nat.Struct.Mol.Biol., 20, 2013
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6T1Z
 | | LmrP from L. lactis, in an outward-open conformation, bound to Hoechst 33342 | | Descriptor: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, DODECYL-ALPHA-D-MALTOSIDE, ... | | Authors: | Hutchin, A, Debruycker, V, Masureel, M, Legrand, P, Remaut, H, Govaerts, C. | | Deposit date: | 2019-10-07 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity.
Nat.Struct.Mol.Biol., 27, 2020
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6R5M
 | | Crystal structure of toxin MT9 from mamba venom | | Descriptor: | ACETYL GROUP, Dendroaspis polylepis MT9, GLYCEROL, ... | | Authors: | Stura, E.A, Tepshi, L, Ciolek, J, Triquigneaux, M, Zoukimian, C, De Waard, M, Beroud, R, Servent, D, Gilles, N, Legrand, P, Ciccone, L. | | Deposit date: | 2019-03-25 | | Release date: | 2020-02-12 | | Last modified: | 2022-05-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries
Biomed Pharmacother, 150, 2022
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2YOE
 | | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with GABA and flurazepam | | Descriptor: | CYS-LOOP LIGAND-GATED ION CHANNEL, Flurazepam, GAMMA-AMINO-BUTANOIC ACID | | Authors: | Spurny, R, Brams, M, Nury, H, Legrand, P, Ulens, C. | | Deposit date: | 2012-10-23 | | Release date: | 2012-10-31 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Pentameric Ligand-Gated Ion Channel Elic is Activated by Gaba and Modulated by Benzodiazepines.
Proc.Natl.Acad.Sci.USA, 109, 2012
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5MWN
 | | Structure of the EAEC T6SS component TssK N-terminal domain in complex with llama nanobodies nbK18 and nbK27 | | Descriptor: | PHOSPHATE ION, Type VI secretion protein, llama nanobody raised against TssK, ... | | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Legrand, P. | | Deposit date: | 2017-01-18 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
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5OYL
 | | VSV G CR2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | | Authors: | Albertini, A.A, Belot, L, Legrand, P, Gaudin, Y. | | Deposit date: | 2017-09-11 | | Release date: | 2018-03-21 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein.
Nat Commun, 9, 2018
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