8V93
 
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9D6F
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8TB7
 | | Cryo-EM Structure of GPR61- | | Descriptor: | 6-{[(3,5-difluoropyridin-4-yl)methyl]amino}-N-(4-ethoxy-6-methylpyrimidin-2-yl)-2-methoxy-N-(2-methoxyethyl)pyridine-3-sulfonamide, Fab hinge-binding nanobody, Fab24 BAK5 heavy chain, ... | | Authors: | Lees, J.A, Dias, J.M, Han, S. | | Deposit date: | 2023-06-28 | | Release date: | 2023-10-04 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun, 14, 2023
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8TB0
 | | Cryo-EM Structure of GPR61-G protein complex stabilized by scFv16 | | Descriptor: | GPR61 fused to dominant negative G alpha S/I N18 chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Lees, J.A, Dias, J.M, Han, S. | | Deposit date: | 2023-06-28 | | Release date: | 2023-10-04 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Nat Commun, 14, 2023
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7UJA
 | | Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab heavy chain, AM14 Fab light chain, ... | | Authors: | Lees, J.A, Ammirati, M, Han, S. | | Deposit date: | 2022-03-30 | | Release date: | 2023-04-19 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine.
Sci Transl Med, 15, 2023
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6BQ1
 | | Human PI4KIIIa lipid kinase complex | | Descriptor: | 5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide, Phosphatidylinositol 4-kinase III alpha (PI4KA), Protein FAM126A, ... | | Authors: | Lees, J.A, Zhang, Y, Oh, M, Schauder, C.M, Yu, X, Baskin, J, Dobbs, K, Notarangelo, L.D, Camilli, P.D, Walz, T, Reinisch, K.M. | | Deposit date: | 2017-11-27 | | Release date: | 2017-12-13 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Architecture of the human PI4KIII alpha lipid kinase complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TOD
 | | Transmembrane protein 24 SMP domain | | Descriptor: | Transmembrane protein 24 | | Authors: | Lees, J.A, Reinisch, K.M. | | Deposit date: | 2016-10-17 | | Release date: | 2017-03-01 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.96 Å) | | Cite: | Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.
Science, 355, 2017
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7L7K
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7L7F
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7K2V
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7K1W
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7K1Y
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9J8E
 | | Structural insights into BirA from Haemophilus influenzae, a bifunctional protein as a biotin protein ligase and a transcriptional repressor | | Descriptor: | BIOTINYL-5-AMP, Bifunctional ligase/repressor BirA | | Authors: | Lee, J.Y, Jeong, K.H, Son, S.B, Ko, J.H. | | Deposit date: | 2024-08-21 | | Release date: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural insights into BirA from Haemophilus influenzae, a bifunctional protein as a biotin protein ligase and a transcriptional repressor.
Biochem.Biophys.Res.Commun., 733, 2024
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9J8F
 | | Structural insights into BirA from Haemophilus influenzae, a bifunctional protein as a biotin protein ligase and a transcriptional repressor | | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Bifunctional ligase/repressor BirA, PENTAETHYLENE GLYCOL | | Authors: | Lee, J.Y, Jeong, K.H, Son, S.B, Ko, J.H. | | Deposit date: | 2024-08-21 | | Release date: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural insights into BirA from Haemophilus influenzae, a bifunctional protein as a biotin protein ligase and a transcriptional repressor.
Biochem.Biophys.Res.Commun., 733, 2024
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9KOI
 | | Crystal structure of ExaC, an NAD+-dependent aldehyde dehydrogenase, from Pseudomonas aeruginosa | | Descriptor: | NAD+ dependent aldehyde dehydrogenase ExaC | | Authors: | Lee, J.Y, Ko, J.H, Jeong, K.H, Son, S.B. | | Deposit date: | 2024-11-20 | | Release date: | 2024-12-11 | | Last modified: | 2025-01-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural analysis of ExaC, an NAD + -dependent aldehyde dehydrogenase, from Pseudomonas aeruginosa.
Biochem.Biophys.Res.Commun., 742, 2025
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9KOK
 | | Crystal structure of ExaC, an NAD+-dependent aldehyde dehydrogenase, from Pseudomonas aeruginosa | | Descriptor: | GLYCEROL, MAGNESIUM ION, NAD+ dependent aldehyde dehydrogenase ExaC, ... | | Authors: | Lee, J.Y, Ko, J.H, Jeong, K.H, Son, S.B. | | Deposit date: | 2024-11-20 | | Release date: | 2025-01-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural analysis of ExaC, an NAD + -dependent aldehyde dehydrogenase, from Pseudomonas aeruginosa.
Biochem.Biophys.Res.Commun., 742, 2025
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2R64
 | | Crystal structure of a 3-aminoindazole compound with CDK2 | | Descriptor: | Cell division protein kinase 2, N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE | | Authors: | Lee, J, Choi, H, Kim, K.H, Jeong, S, Park, J.W, Baek, C.S, Lee, S.H. | | Deposit date: | 2007-09-05 | | Release date: | 2008-09-09 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
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5WQ0
 | | Receiver domain of Spo0A from Paenisporosarcina sp. TG-14 | | Descriptor: | MAGNESIUM ION, Stage 0 sporulation protein | | Authors: | Lee, J.H, Lee, C.W. | | Deposit date: | 2016-11-22 | | Release date: | 2017-03-22 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.604 Å) | | Cite: | Crystal structure of the inactive state of the receiver domain of Spo0A from Paenisporosarcina sp. TG-14, a psychrophilic bacterium isolated from an Antarctic glacier
J. Microbiol., 55, 2017
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1JYS
 | | Crystal Structure of E. coli MTA/AdoHcy Nucleosidase | | Descriptor: | ADENINE, MTA/SAH nucleosidase | | Authors: | Lee, J.E, Cornell, K.A, Riscoe, M.K, Howell, P.L. | | Deposit date: | 2001-09-13 | | Release date: | 2002-10-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases.
Structure, 9, 2001
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4G4E
 | | Crystal structure of the L88A mutant of HslV from Escherichia coli | | Descriptor: | ATP-dependent protease subunit HslV | | Authors: | Lee, J.W, Park, E, Yoo, H.M, Ha, B.H, An, J.Y, Jeon, Y.J, Seol, J.H, Eom, S.H, Chung, C.H. | | Deposit date: | 2012-07-16 | | Release date: | 2013-06-12 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.888 Å) | | Cite: | Structural Alteration in the Pore Motif of the Bacterial 20S Proteasome Homolog HslV Leads to Uncontrolled Protein Degradation
J.Mol.Biol., 425, 2013
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3UYU
 | | Structural basis for the antifreeze activity of an ice-binding protein (LeIBP) from Arctic yeast | | Descriptor: | Antifreeze protein, GLYCEROL | | Authors: | Lee, J.H, Park, A.K, Do, H, Park, K.S, Moh, S.H, Chi, Y.M, Kim, H.J. | | Deposit date: | 2011-12-06 | | Release date: | 2012-02-15 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Structural basis for the antifreeze activity of an ice-binding protein from an Arctic yeast.
J.Biol.Chem., 2012
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7C4X
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6KTB
 | | Crystal structure of B. halodurans MntR in apo form | | Descriptor: | HTH-type transcriptional regulator MntR, MAGNESIUM ION, MANGANESE (II) ION, ... | | Authors: | Lee, J.Y, Lee, M.Y. | | Deposit date: | 2019-08-26 | | Release date: | 2019-12-04 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural analysis of the manganese transport regulator MntR from Bacillus halodurans in apo and manganese bound forms.
Plos One, 14, 2019
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5AWN
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8VQ9
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