7UJA

Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A)

Summary for 7UJA

Entry DOI	10.2210/pdb7uja/pdb
EMDB information	26562
Descriptor	RSV variant (construct pXCS847A) F1, AM14 Fab heavy chain, AM14 Fab light chain, ... (7 entities in total)
Functional Keywords	rsv, rsvf, pre-fusion, viral protein
Biological source	Respiratory syncytial virus More
Total number of polymer chains	18
Total formula weight	470470.17
Authors	Lees, J.A.,Ammirati, M.,Han, S. (deposition date: 2022-03-30, release date: 2023-04-19, Last modification date: 2023-05-10)
Primary citation	Che, Y.,Gribenko, A.V.,Song, X.,Handke, L.D.,Efferen, K.S.,Tompkins, K.,Kodali, S.,Nunez, L.,Prasad, A.K.,Phelan, L.M.,Ammirati, M.,Yu, X.,Lees, J.A.,Chen, W.,Martinez, L.,Roopchand, V.,Han, S.,Qiu, X.,DeVincenzo, J.P.,Jansen, K.U.,Dormitzer, P.R.,Swanson, K.A. Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine. Sci Transl Med, 15:eade6422-eade6422, 2023 Cited by PubMed: 37023209 DOI: 10.1126/scitranslmed.ade6422 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation