7UJA
Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, K | RSV variant (construct pXCS847A) F1 | polymer | 410 | 45025.4 | 3 | UniProt (A0A7D5GVC1) Pfam (PF00523) UniProt (by SIFTS) (A0A218N9U8) In PDB | Respiratory syncytial virus | |
| 2 | B, G, L | AM14 Fab heavy chain | polymer | 245 | 26231.1 | 3 | Mus musculus | ||
| 3 | D, H, M | AM14 Fab light chain | polymer | 218 | 23972.7 | 3 | Mus musculus | ||
| 4 | E, I, N | AM22 Fab heavy chain | polymer | 246 | 25989.2 | 3 | Mus musculus | ||
| 5 | F, J, O | AM22 Fab light chain | polymer | 215 | 23273.9 | 3 | Mus musculus | ||
| 6 | P, Q, R | RSV variant (construct pXCS847A) F2 | polymer | 109 | 12110.0 | 3 | UniProt (A0A7D5GVC1) Pfam (PF00523) UniProt (by SIFTS) (E0WLS1) In PDB | Respiratory syncytial virus | |
| 7 | A, C, K | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A, C, K: 137 - 513 (UniProt: A0A7D5GVC1)
P, Q, R: 4 - 109 (UniProt: A0A7D5GVC1)
| PDB | External Database | Details |
|---|---|---|
| Cys 148 | Ile 145 | engineered mutation |
| Ile 190 | Ser 187 | engineered mutation |
| Ser 486 | Asp 483 | engineered mutation |
| Ser 514 | - | expression tag |
| Ala 515 | - | expression tag |
| Ile 516 | - | expression tag |
| Gly 517 | - | expression tag |
| Gly 518 | - | expression tag |
| Tyr 519 | - | expression tag |
| Ile 520 | - | expression tag |
| Pro 521 | - | expression tag |
| Glu 522 | - | expression tag |
| Ala 523 | - | expression tag |
| Pro 524 | - | expression tag |
| Arg 525 | - | expression tag |
| Asp 526 | - | expression tag |
| Gly 527 | - | expression tag |
| Gln 528 | - | expression tag |
| Ala 529 | - | expression tag |
| Tyr 530 | - | expression tag |
| Val 531 | - | expression tag |
| Arg 532 | - | expression tag |
| Lys 533 | - | expression tag |
| Asp 534 | - | expression tag |
| Gly 535 | - | expression tag |
| Glu 536 | - | expression tag |
| Trp 537 | - | expression tag |
| Val 538 | - | expression tag |
| Leu 539 | - | expression tag |
| Leu 540 | - | expression tag |
| Ser 541 | - | expression tag |
| Thr 542 | - | expression tag |
| Phe 543 | - | expression tag |
| Leu 544 | - | expression tag |
| Gly 545 | - | expression tag |
| Gly 546 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Glu 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Cys 103 | Ala 100 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 469806.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 470470.2 |
