5HS3
 
 | | Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol, Thymidylate synthase | | 著者 | Chen, D, Almqvist, H, Axelsson, H, Jafari, R, Mateus, A, Haraldsson, M, Larsson, A, Artursson, P, Molina, D.M, Lundback, T, Nordlund, P. | | 登録日 | 2016-01-25 | | 公開日 | 2016-02-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.103 Å) | | 主引用文献 | CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Nat Commun, 7, 2016
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5X5A
 | | Human thymidylate synthase bound with phosphate ion | | 分子名称: | PHOSPHATE ION, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-15 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
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5X66
 | | Human thymidylate synthase in complex with dUMP and methotrexate | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-21 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
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5X4Y
 | | Mutant human thymidylate synthase M190K crystallized in a sulfate-containing condition | | 分子名称: | SULFATE ION, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-14 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
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5X5Q
 | | Human thymidylate synthase complexed with dUMP and raltitrexed | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-17 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
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5X67
 | | Human thymidylate synthase in complex with dUMP and nolatrexed | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-21 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
J. Biol. Chem., 292, 2017
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5YFM
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5YFN
 | | Human isocitrate dehydrogenase 1 bound with isocitrate | | 分子名称: | ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, MAGNESIUM ION, ... | | 著者 | Nordlund, P, Chen, D, Jansson, A, Larsson, A. | | 登録日 | 2017-09-21 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Human isocitrate dehydrogenase 1 bound with isocitrate
To Be Published
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5X4W
 | | Mutant human thymidylate synthase A191K crystallized in a sulfate-free condition | | 分子名称: | PHOSPHATE ION, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-14 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
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5X4X
 | | Mutant human thymidylate synthase A191K crystallized in a sulfate-containing condition | | 分子名称: | SULFATE ION, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-14 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
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5X69
 | | Human thymidylate synthase with a fragment bound in the dimer interface | | 分子名称: | 1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-21 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
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5X5D
 | | Human thymidylate synthase bound with dUMP | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase | | 著者 | Chen, D, Jansson, A, Larsson, A, Nordlund, P. | | 登録日 | 2017-02-15 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
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