4X21
 
 | | The MAP kinase JNK3 as target for halogen bonding | | Descriptor: | CHLORIDE ION, Mitogen-activated protein kinase 10, N-ethyl-4-{[4-(1H-indol-3-yl)-5-iodopyrimidin-2-yl]amino}piperidine-1-carboxamide | | Authors: | Lange, A, Buettner, F.M, Guenther, M.B, Zimmermann, M.O, Hennig, S, Laufer, S.A, Stehle, T, Boeckler, F. | | Deposit date: | 2014-11-25 | | Release date: | 2015-11-11 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond.
J.Am.Chem.Soc., 137, 2015
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1XSW
 | | The solid-state NMR structure of Kaliotoxin | | Descriptor: | Kaliotoxin 1 | | Authors: | Lange, A, Becker, S, Seidel, K, Giller, K, Pongs, O, Baldus, M. | | Deposit date: | 2004-10-20 | | Release date: | 2005-04-05 | | Last modified: | 2022-03-02 | | Method: | SOLID-STATE NMR | | Cite: | A Concept for Rapid Protein-Structure Determination by Solid-State NMR Spectroscopy
Angew.Chem.Int.Ed.Engl., 44, 2005
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2L0T
 | | Solution structure of the complex of ubiquitin and the VHS domain of Stam2 | | Descriptor: | Signal transducing adapter molecule 2, Ubiquitin | | Authors: | Lange, A, Hoeller, D, Wienk, H, Marcillat, O, Lancelin, J, Walker, O. | | Deposit date: | 2010-07-15 | | Release date: | 2010-12-15 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | NMR reveals a different mode of binding of the Stam2 VHS domain to ubiquitin and diubiquitin.
Biochemistry, 50, 2011
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5N8O
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4JVD
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4JVI
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4JVC
 | | Crystal structure of PqsR co-inducer binding domain | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Transcriptional regulator MvfR | | Authors: | Ilangovan, A, Emsley, J, Williams, P. | | Deposit date: | 2013-03-25 | | Release date: | 2013-08-07 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR).
Plos Pathog., 9, 2013
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3C1U
 | | D192N mutant of Rhamnogalacturonan acetylesterase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Rhamnogalacturonan acetylesterase | | Authors: | Langkilde, A, Lo Leggio, L, Navarro Poulsen, J.C, Molgaard, A, Larsen, S. | | Deposit date: | 2008-01-24 | | Release date: | 2008-08-05 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase
ACTA CRYSTALLOGR.,SECT.D, 64, 2008
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1C12
 | | INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE | | Descriptor: | PROTEIN (ANTIBODY FRAGMENT FAB), TRAZEOLIDE | | Authors: | Langedijk, A.C, Spinelli, S, Anguille, C, Hermans, P, Nederlof, J, Butenandt, J, Honegger, A, Cambillau, C, Pluckthun, A. | | Deposit date: | 1999-07-20 | | Release date: | 1999-08-14 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Insight into odorant perception: the crystal structure and binding characteristics of antibody fragments directed against the musk odorant traseolide.
J.Mol.Biol., 292, 1999
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4L0J
 | | Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems | | Descriptor: | DNA helicase I, MAGNESIUM ION, SULFATE ION | | Authors: | Redzej, A, Ilangovan, A, Lang, S, Gruber, C.J, Topf, M, Zangger, K, Zechner, E.L, Waksman, G. | | Deposit date: | 2013-05-31 | | Release date: | 2013-06-19 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems.
Mol.Microbiol., 89, 2013
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1JJ9
 | | Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition | | Descriptor: | 2-HYDROXY-5-[4-(2-HYDROXY-ETHYL)-PIPERIDIN-1-YL]-5-PHENYL-1H-PYRIMIDINE-4,6-DIONE, CALCIUM ION, Matrix Metalloproteinase 8, ... | | Authors: | Brandstetter, H, Grams, F, Glitz, D, Lang, A, Huber, R, Bode, W, Krell, H.-W, Engh, R.A. | | Deposit date: | 2001-07-04 | | Release date: | 2001-08-01 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.
J.Biol.Chem., 276, 2001
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4D07
 | | DYNLL2 dynein light chain binds to an extended, unstructured linear motif of myosin 5a tail | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, COBALT (II) ION, DYNEIN LIGHT CHAIN 2, ... | | Authors: | Bodor, A, Radnai, L, Hetenyi, C, Rapali, P, Lang, A, Kover, K.E, Perczel, A, Wahlgren, W.Y, Katona, G, Nyitray, L. | | Deposit date: | 2014-04-24 | | Release date: | 2014-10-22 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Dynll2 Dynein Light Chain Binds to an Extended Linear Motif of Myosin 5A Tail that Has Structural Plasticity.
Biochemistry, 53, 2014
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4O9Y
 | | Crystal Structure of TcdA1 | | Descriptor: | TcdA1 | | Authors: | Meusch, D, Gatsogiannis, C, Efremov, R.G, Lang, A.E, Hofnagel, O, Vetter, I.R, Aktories, K, Raunser, S. | | Deposit date: | 2014-01-03 | | Release date: | 2014-02-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.502 Å) | | Cite: | Mechanism of Tc toxin action revealed in molecular detail.
Nature, 508, 2014
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4O9X
 | | Crystal Structure of TcdB2-TccC3 | | Descriptor: | MERCURY (II) ION, TcdB2, TccC3 | | Authors: | Meusch, D, Gatsogiannis, C, Efremov, R.G, Lang, A.E, Hofnagel, O, Vetter, I.R, Aktories, K, Raunser, S. | | Deposit date: | 2014-01-03 | | Release date: | 2014-02-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Mechanism of Tc toxin action revealed in molecular detail.
Nature, 508, 2014
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1RFN
 | | HUMAN COAGULATION FACTOR IXA IN COMPLEX WITH P-AMINO BENZAMIDINE | | Descriptor: | CALCIUM ION, P-AMINO BENZAMIDINE, PROTEIN (COAGULATION FACTOR IX), ... | | Authors: | Hopfner, K.-P, Lang, A, Karcher, A, Sichler, K, Kopetzki, E, Brandstetter, H, Huber, R, Bode, W, Engh, R.A. | | Deposit date: | 1999-04-19 | | Release date: | 1999-09-01 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.
Structure Fold.Des., 7, 1999
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2RNM
 | | Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR | | Descriptor: | Small s protein | | Authors: | Wasmer, C, Lange, A, Van Melckebeke, H, Siemer, A, Riek, R, Meier, B.H. | | Deposit date: | 2008-01-24 | | Release date: | 2008-04-01 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core
Science, 319, 2008
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6YEG
 | | Hybrid structure of the SPP1 tail tube by solid-state NMR and cryo EM - Final EM Refinement | | Descriptor: | Tail tube protein gp17.1* | | Authors: | Zinke, M, Sachowsky, K.A.A, Zinn-Justin, S, Ravelli, R, Schroder, G.F, Habeck, M, Lange, A. | | Deposit date: | 2020-03-24 | | Release date: | 2020-10-14 | | Last modified: | 2023-09-13 | | Method: | ELECTRON MICROSCOPY (4 Å), SOLID-STATE NMR | | Cite: | Architecture of the flexible tail tube of bacteriophage SPP1.
Nat Commun, 11, 2020
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6YQ5
 | | Hybrid structure of the SPP1 tail tube by solid-state NMR and cryo EM - NMR Ensemble | | Descriptor: | Tail tube protein gp17.1* | | Authors: | Zinke, M, Sachowsky, K.A.A, Zinn-Justin, S, Ravelli, R, Schroder, G.F, Habeck, M, Lange, A. | | Deposit date: | 2020-04-16 | | Release date: | 2020-10-14 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (4 Å), SOLID-STATE NMR | | Cite: | Architecture of the flexible tail tube of bacteriophage SPP1.
Nat Commun, 11, 2020
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2X9C
 | | Crystal structure of a soluble PrgI mutant from Salmonella Typhimurium | | Descriptor: | PROTEIN PRGI | | Authors: | Poyraz, O, Schmidt, H, Seidel, K, Delissen, F, Ader, C, Tenenboim, H, Goosmann, C, Laube, B, Thuenemann, A.F, Zychlinsky, A, Baldus, M, Lange, A, Griesinger, C, Kolbe, M. | | Deposit date: | 2010-03-15 | | Release date: | 2010-06-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Protein Refolding is Required for Assembly of the Type Three Secretion Needle
Nat.Struct.Mol.Biol., 17, 2010
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1TIP
 | | THE BISPHOSPHATASE DOMAIN OF THE BIFUNCTIONAL RAT LIVER 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE | | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, PHOSPHOENZYME INTERMEDIATE OF FRU-2,6-BISPHOSPHATASE | | Authors: | Lee, Y.-H, Olson, T.W, Ogata, C.M, Levitt, D.G, Banaszak, L.J, Lange, A.J. | | Deposit date: | 1997-05-28 | | Release date: | 1998-01-28 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of a trapped phosphoenzyme during a catalytic reaction.
Nat.Struct.Biol., 4, 1997
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2UVS
 | | High Resolution Solid-state NMR structure of Kaliotoxin | | Descriptor: | POTASSIUM CHANNEL TOXIN ALPHA-KTX 3.1 | | Authors: | Korukottu, J, Lange, A, Vijayan, V, Schneider, R, Pongs, O, Becker, S, Baldus, M, Zweckstetter, M. | | Deposit date: | 2007-03-14 | | Release date: | 2008-05-27 | | Last modified: | 2020-01-15 | | Method: | SOLID-STATE NMR | | Cite: | Conformational Plasticity in Ion Channel Recognition of a Peptide Toxin
To be Published
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1UN0
 | | Crystal Structure of Yeast Karyopherin (Importin) alpha in complex with a Nup2p N-terminal fragment | | Descriptor: | IMPORTIN ALPHA SUBUNIT, NUCLEOPORIN NUP2 | | Authors: | Matsuura, Y, Lange, A, Harreman, M.T, Corbett, A.H, Stewart, M. | | Deposit date: | 2003-09-03 | | Release date: | 2003-10-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Basis for Nup2P Function in Cargo Release and Karyopherin Recycling in Nuclear Import
Embo J., 22, 2003
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1C7Z
 | | REGULATORY COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE | | Descriptor: | FRUCTOSE-2,6-BISPHOSPHATASE, GLYCERALDEHYDE-3-PHOSPHATE, PHOSPHATE ION | | Authors: | Lee, Y.H, Olson, T.W, McClard, R.W, Witte, J.F, McFarlan, S.C, Banaszak, L.J, Levitt, D.G, Lange, A.J. | | Deposit date: | 2000-04-03 | | Release date: | 2003-06-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Reaction Mechanism of Fructose-2,6-bisphosphatase Suggested by the Crystal Structures of a pseudo-Michaelis complex and Metabolite Complexes
To be Published
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1C80
 | | REGULATORY COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE | | Descriptor: | FRUCTOSE-2,6-BISPHOSPHATASE, GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION | | Authors: | Lee, Y.H, Olson, T.W, McClard, R.W, Witte, J.F, McFarlan, S.C, Banaszak, L.J, Levitt, D.G, Lange, A.J. | | Deposit date: | 2000-04-03 | | Release date: | 2003-06-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Reaction Mechanism of Fructose-2,6-bisphosphatase Suggested by the Crystal Structures of a pseudo-Michaelis complex and Metabolite Complexes
To be Published
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1C81
 | | MICHAELIS COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE | | Descriptor: | 2,5-anhydro-1-deoxy-1-phosphono-6-O-phosphono-D-glucitol, FRUCTOSE-2,6-BISPHOSPHATASE | | Authors: | Lee, Y.H, Olson, T.W, McClard, R.W, Witte, J.F, McFarlan, S.C, Banaszak, L.J, Levitt, D.G, Lange, A.J. | | Deposit date: | 2000-04-03 | | Release date: | 2003-06-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Reaction Mechanism of Fructose-2,6-bisphosphatase Suggested by the Crystal Structures of a pseudo-Michaelis complex and Metabolite Complexes
To be Published
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