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PDB: 313 件
3E8H
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Crystal Structure of the the open NaK channel-K+ complex
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein
著者Jiang, Y, Alam, A.
登録日2008-08-19
公開日2008-12-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural analysis of ion selectivity in the NaK channel
Nat.Struct.Mol.Biol., 16, 2009
6CUL
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BU of 6cul by Molmil
PvdF of pyoverdin biosynthesis is a structurally unique N10-formyltetrahydrofolate-dependent formyltransferase
分子名称: CITRIC ACID, N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl]amino}benzene-1-carbonyl)-D-glutamic acid, Pyoverdine synthetase F
著者Kenjic, N, Hoag, M.R, Moraski, G.C, Caperelli, C.A, Moran, G.R, Lamb, A.L.
登録日2018-03-26
公開日2019-02-06
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献PvdF of pyoverdin biosynthesis is a structurally unique N10-formyltetrahydrofolate-dependent formyltransferase.
Arch. Biochem. Biophys., 664, 2019
6NN7
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The structure of human liver pyruvate kinase, hLPYK-GGG
分子名称: 1,2-ETHANEDIOL, CITRATE ANION, GLYCEROL, ...
著者McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L.
登録日2019-01-14
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond.
Acta Crystallogr.,Sect.F, 75, 2019
6NN8
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The structure of human liver pyruvate kinase, hLPYK-S531E
分子名称: 1,2-ETHANEDIOL, Pyruvate kinase PKLR
著者McFarlane, J.S, Ronnebaum, T.A, Meneely, K.M, Fenton, A.W, Lamb, A.L.
登録日2019-01-14
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.416 Å)
主引用文献Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond.
Acta Crystallogr.,Sect.F, 75, 2019
6DQO
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Crystal structure of SsuE FMN reductase Y118A mutant in FMN bound form.
分子名称: FLAVIN MONONUCLEOTIDE, FMN reductase (NADPH), GLYCEROL
著者McFarlane, J.S, Ellis, H.R, Lamb, A.L.
登録日2018-06-11
公開日2019-01-09
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.705 Å)
主引用文献Not as easy as pi : An insertional residue does not explain the pi-helix gain-of-function in two-component FMN reductases.
Protein Sci., 28, 2019
3S61
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Reduced Form of Ornithine Hydroxylase (PvdA) from Pseudomonas aeruginosa
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, L-ornithine, L-ornithine 5-monooxygenase, ...
著者Olucha, J, Lamb, A.L.
登録日2011-05-23
公開日2011-07-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Two Structures of an N-Hydroxylating Flavoprotein Monooxygenase: ORNITHINE HYDROXYLASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 286, 2011
3HGX
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Crystal Structure of Pseudomonas aeruginosa Isochorismate-Pyruvate Lyase K42A mutant in complex with salicylate and pyruvate
分子名称: 2-HYDROXYBENZOIC ACID, PYRUVIC ACID, Salicylate biosynthesis protein pchB
著者Luo, Q, Lamb, A.L.
登録日2009-05-14
公開日2009-06-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-function analyses of isochorismate-pyruvate lyase from Pseudomonas aeruginosa suggest differing catalytic mechanisms for the two pericyclic reactions of this bifunctional enzyme.
Biochemistry, 48, 2009
3E8B
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Crystal Structure of the the open NaK channel- Rb+ complex
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein, RUBIDIUM ION
著者Jiang, Y, Alam, A.
登録日2008-08-19
公開日2008-12-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural analysis of ion selectivity in the NaK channel
Nat.Struct.Mol.Biol., 16, 2009
5OLB
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crystal structure of autotaxin in complex with PF-8380
分子名称: (3,5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Hoerer, S, Lammens, A.
登録日2017-07-27
公開日2018-01-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo.
ACS Med Chem Lett, 8, 2017
3Q5J
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Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin
分子名称: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-{[3-(dimethylamino)propyl]amino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, Heat shock protein 83-1
著者Wernimont, A.K, Tempel, W, Lin, Y.H, Hutchinson, A, MacKenzie, F, Fairlamb, A, Cossar, D, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC)
登録日2010-12-28
公開日2011-02-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin.
To be Published
6AR5
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BU of 6ar5 by Molmil
Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications (Duplex Only)
分子名称: DNA, RNA
著者Stamos, J.L, Lentzsch, A.M, Lambowitz, A.M.
登録日2017-08-21
公開日2017-11-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.413 Å)
主引用文献Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications.
Mol. Cell, 68, 2017
3S5W
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Ornithine Hydroxylase (PvdA) from Pseudomonas aeruginosa
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, L-ornithine 5-monooxygenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Olucha, J, Lamb, A.L.
登録日2011-05-23
公開日2011-07-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Two Structures of an N-Hydroxylating Flavoprotein Monooxygenase: ORNITHINE HYDROXYLASE FROM PSEUDOMONAS AERUGINOSA.
J.Biol.Chem., 286, 2011
2XIM
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BU of 2xim by Molmil
ARGININE RESIDUES AS STABILIZING ELEMENTS IN PROTEINS
分子名称: D-XYLOSE ISOMERASE, MAGNESIUM ION, Xylitol
著者Mrabet, N.T, Van Denbroek, A, Van Den Brande, I, Stanssens, P, Laroche, Y, Lambeir, A.-M, Matthyssens, G, Jenkins, J, Chiadmi, M, Vantilbeurgh, H, Rey, F, Janin, J, Quax, W.J, Lasters, I, Demaeyer, M, Wodak, S.J.
登録日1991-05-29
公開日1993-04-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Arginine residues as stabilizing elements in proteins.
Biochemistry, 31, 1992
6AZW
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BU of 6azw by Molmil
IDO1/FXB-001116 crystal structure
分子名称: (2R)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide, Indoleamine 2,3-dioxygenase 1
著者Lewis, H.A, Lammens, A, Steinbacher, S.
登録日2017-09-13
公開日2018-03-21
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1M1O
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BU of 1m1o by Molmil
Crystal structure of biosynthetic thiolase, C89A mutant, complexed with acetoacetyl-CoA
分子名称: ACETOACETYL-COENZYME A, Acetyl-CoA acetyltransferase, SULFATE ION
著者Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
登録日2002-06-20
公開日2002-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002
1M1T
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Biosynthetic thiolase, Q64A mutant
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION
著者Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
登録日2002-06-20
公開日2002-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002
1M3Z
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Biosynthetic thiolase, C89A mutant, complexed with acetyl coenzyme A
分子名称: ACETYL COENZYME *A, Acetyl-CoA acetyltransferase, SULFATE ION
著者Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
登録日2002-07-03
公開日2002-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002
2VUP
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Crystal structure of a type II tryparedoxin-dependant peroxidase from Trypanosoma brucei
分子名称: GLUTATHIONE PEROXIDASE-LIKE PROTEIN
著者Alphey, M.S, Konig, J, Fairlamb, A.H.
登録日2008-05-28
公開日2008-06-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Mechanistic Insights Into Type II Trypanosomatid Tryparedoxin-Dependent Peroxidases.
Biochem.J., 414, 2008
1M4T
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Biosynthetic thiolase, Cys89 butyrylated
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION
著者Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
登録日2002-07-03
公開日2002-11-29
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002
1M3K
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biosynthetic thiolase, inactive C89A mutant
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION
著者Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
登録日2002-06-28
公開日2002-11-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002
2VPM
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Trypanothione synthetase
分子名称: BROMIDE ION, CHLORIDE ION, TRYPANOTHIONE SYNTHETASE
著者Fyfe, P.K, Oza, S.L, Fairlamb, A.H, Hunter, W.N.
登録日2008-03-03
公開日2008-05-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities.
J.Biol.Chem., 283, 2008
2B2N
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Structure of transcription-repair coupling factor
分子名称: O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL, SODIUM ION, SULFATE ION, ...
著者Assenmacher, N, Wenig, K, Lammens, A, Hopfner, K.-P.
登録日2005-09-19
公開日2006-01-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Basis for Transcription-coupled Repair: the N Terminus of Mfd Resembles UvrB with Degenerate ATPase Motifs
J.Mol.Biol., 355, 2006
3Q5L
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BU of 3q5l by Molmil
Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K 213 in the presence of 17-AEP-geldanamycin
分子名称: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-{[2-(pyrrolidin-1-yl)ethyl]amino}-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate, Heat shock protein 83-1
著者Wernimont, A.K, Tempel, W, Lin, Y.H, Hutchinson, A, MacKenzie, F, Fairlamb, A, Cossar, D, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC)
登録日2010-12-28
公開日2011-02-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K 213 in the presence of 17-AEP-geldanamycin.
To be Published
3Q5K
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Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of an inhibitor
分子名称: 4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]-2-{[2-(methylsulfanyl)ethyl]amino}benzamide, Heat shock protein 83-1
著者Wernimont, A.K, Tempel, W, Lin, Y.H, Hutchinson, A, MacKenzie, F, Fairlamb, A, Cossar, D, Zhao, Y, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Ferguson, M.A.J, Hui, R, Pizarro, J.C, Hills, T, Structural Genomics Consortium (SGC)
登録日2010-12-28
公開日2011-02-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of an inhibitor
To be Published
1M4S
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BU of 1m4s by Molmil
Biosynthetic thiolase, Cys89 acetylated, unliganded form
分子名称: Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION
著者Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K.
登録日2002-07-03
公開日2002-11-29
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
Biochemistry, 41, 2002

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