4V7G
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![BU of 4v7g by Molmil](/molmil-images/mine/4v7g) | Crystal Structure of Lumazine Synthase from Bacillus Anthracis | Descriptor: | 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | Authors: | Morgunova, E, Illarionov, B, Saller, S, Popov, A, Sambaiah, T, Bacher, A, Cushman, M, Fischer, M, Ladenstein, R. | Deposit date: | 2009-09-16 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis. Acta Crystallogr.,Sect.D, 66, 2010
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1MG5
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![BU of 1mg5 by Molmil](/molmil-images/mine/1mg5) | Crystal structure of Drosophila melanogaster alcohol dehydrogenase complexed with NADH and acetate at 1.6 A | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ACETATE ION, alcohol dehydrogenase | Authors: | Benach, J, Atrian, S, Gonzalez-Duarte, R, Ladenstein, R. | Deposit date: | 2002-08-14 | Release date: | 2003-10-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Drosophila alcohol dehydrogenase: acetate-enzyme interactions and novel insights into the effects of electrostatics on catalysis J.Mol.Biol., 345, 2005
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3HI8
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![BU of 3hi8 by Molmil](/molmil-images/mine/3hi8) | Crystal structure of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii | Descriptor: | Proliferating cell nuclear antigen PcnA | Authors: | Morgunova, E, Gray, F.C, MacNeill, S.A, Ladenstein, R. | Deposit date: | 2009-05-19 | Release date: | 2009-09-29 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.202 Å) | Cite: | Structural insights into the adaptation of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii to a high-salt environment. Acta Crystallogr.,Sect.D, 65, 2009
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3RJ9
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![BU of 3rj9 by Molmil](/molmil-images/mine/3rj9) | Structure of alcohol dehydrogenase from Drosophila lebanonesis T114V mutant complexed with NAD+ | Descriptor: | Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Morgunova, E, Wuxiuer, Y, Cols, N, Popov, A, Sylte, I, Karshikoff, A, Gonzales-Duarte, R, Ladenstein, R, Winberg, J.O. | Deposit date: | 2011-04-15 | Release date: | 2012-05-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. Febs J., 279, 2012
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3RJ5
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![BU of 3rj5 by Molmil](/molmil-images/mine/3rj5) | Structure of alcohol dehydrogenase from Drosophila lebanonesis T114V mutant complexed with NAD+ | Descriptor: | ACETIC ACID, Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Morgunova, E, Wuxiuer, Y, Cols, N, Popov, A, Sylte, I, Karshikoff, A, Gonzales-Duarte, R, Ladenstein, R, Winberg, J.O. | Deposit date: | 2011-04-15 | Release date: | 2012-05-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity. Febs J., 279, 2012
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1JM1
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![BU of 1jm1 by Molmil](/molmil-images/mine/1jm1) | Crystal structure of the soluble domain of the Rieske protein II (soxF) from Sulfolobus acidocaldarius | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, MAGNESIUM ION, Rieske iron-sulfur protein soxF | Authors: | Boenisch, H, Schmidt, C.L, Schaefer, G, Ladenstein, R. | Deposit date: | 2001-07-17 | Release date: | 2002-07-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | The structure of the soluble domain of an archaeal Rieske iron-sulfur protein at 1.1 A resolution. J.Mol.Biol., 319, 2002
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2P4W
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![BU of 2p4w by Molmil](/molmil-images/mine/2p4w) | Crystal structure of heat shock regulator from Pyrococcus furiosus | Descriptor: | SULFATE ION, Transcriptional regulatory protein arsR family | Authors: | Liu, W, Vierke, G, Panjikar, S, Thomm, M, Ladenstein, R. | Deposit date: | 2007-03-13 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of the Archaeal Heat Shock Regulator from Pyrococcus furiosus: A Molecular Chimera Representing Eukaryal and Bacterial Features. J.Mol.Biol., 369, 2007
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1XGV
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![BU of 1xgv by Molmil](/molmil-images/mine/1xgv) | Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix | Descriptor: | Isocitrate dehydrogenase | Authors: | Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N.-K, Ladenstein, R. | Deposit date: | 2004-09-17 | Release date: | 2005-09-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability J.Mol.Biol., 345, 2005
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2IV0
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![BU of 2iv0 by Molmil](/molmil-images/mine/2iv0) | Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers | Descriptor: | CHLORIDE ION, ISOCITRATE DEHYDROGENASE, ZINC ION | Authors: | Stokke, R, Karlstrom, M, Yang, N, Leiros, I, Ladenstein, R, Birkeland, N.K, Steen, I.H. | Deposit date: | 2006-06-08 | Release date: | 2007-04-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Thermal Stability of Isocitrate Dehydrogenase from Archaeoglobus Fulgidus Studied by Crystal Structure Analysis and Engineering of Chimers Extremophiles, 11, 2007
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2JFB
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![BU of 2jfb by Molmil](/molmil-images/mine/2jfb) | 3D Structure of Lumazine Synthase from Candida albicans | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE, PHOSPHATE ION | Authors: | Morgunova, E, Fischer, M, Cushman, M, Bacher, A, Ladenstein, R. | Deposit date: | 2007-01-30 | Release date: | 2007-05-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Lumazine Synthase from Candida Albicans as an Anti- Fungal Target Enzyme: Structural and Biochemical Basis for Drug Design. J.Biol.Chem., 282, 2007
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1XKD
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![BU of 1xkd by Molmil](/molmil-images/mine/1xkd) | Ternary complex of Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix | Descriptor: | CALCIUM ION, ISOCITRIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N.-K, Ladenstein, R. | Deposit date: | 2004-09-28 | Release date: | 2005-10-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability. J.Mol.Biol., 345, 2005
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1ZOR
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![BU of 1zor by Molmil](/molmil-images/mine/1zor) | Isocitrate dehydrogenase from the hyperthermophile Thermotoga maritima | Descriptor: | SODIUM ION, isocitrate dehydrogenase | Authors: | Karlstrom, M, Steen, I.H, Birkeland, N.-K, Ladenstein, R. | Deposit date: | 2005-05-13 | Release date: | 2006-05-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | The crystal structure of a hyperthermostable subfamily II isocitrate dehydrogenase from Thermotoga maritima. Febs J., 273, 2006
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1W29
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![BU of 1w29 by Molmil](/molmil-images/mine/1w29) | Lumazine Synthase from Mycobacterium tuberculosis bound to 3-(1,3,7- trihydro-9-D-ribityl-2,6,8-purinetrione-7-yl)butane 1-phosphate | Descriptor: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, 4-{2,6,8-TRIOXO-9-[(2R,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, 4-{2,6,8-TRIOXO-9-[(2S,3R,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, ... | Authors: | Morgunova, E, Meining, W, Illarionov, B, Haase, I, Fischer, M, Cushman, M, Bacher, A, Ladenstein, R. | Deposit date: | 2004-07-01 | Release date: | 2005-03-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,) Biochemistry, 44, 2005
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1W19
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![BU of 1w19 by Molmil](/molmil-images/mine/1w19) | Lumazine Synthase from Mycobacterium tuberculosis bound to 3-(1,3,7- trihydro-9-D-ribityl-2,6,8-purinetrione-7-yl)propane 1-phosphate | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, (4S,5S)-1,2-DITHIANE-4,5-DIOL, ... | Authors: | Morgunova, E, Meining, W, Illarionov, B, Haase, I, Fischer, M, Cushman, M, Bacher, A, Ladenstein, R. | Deposit date: | 2004-06-03 | Release date: | 2005-03-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,) Biochemistry, 44, 2005
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1TYO
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![BU of 1tyo by Molmil](/molmil-images/mine/1tyo) | Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix in complex with etheno-NADP | Descriptor: | ETHENO-NADP, isocitrate dehydrogenase | Authors: | Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N, Ladenstein, R. | Deposit date: | 2004-07-08 | Release date: | 2005-07-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability J.Mol.Biol., 345, 2005
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2VL6
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![BU of 2vl6 by Molmil](/molmil-images/mine/2vl6) | STRUCTURAL ANALYSIS OF THE SULFOLOBUS SOLFATARICUS MCM PROTEIN N- TERMINAL DOMAIN | Descriptor: | MINICHROMOSOME MAINTENANCE PROTEIN MCM, ZINC ION | Authors: | Liu, W, Pucci, B, Rossi, M, Pisani, F.M, Ladenstein, R. | Deposit date: | 2008-01-08 | Release date: | 2008-04-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Analysis of the Sulfolobus Solfataricus Mcm Protein N-Terminal Domain. Nucleic Acids Res., 36, 2008
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2VLD
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![BU of 2vld by Molmil](/molmil-images/mine/2vld) | crystal structure of a repair endonuclease from Pyrococcus abyssi | Descriptor: | Endonuclease NucS | Authors: | Ren, B, Kuhn, J, Meslet-Cladiere, L, Briffotaux, J, Norais, C, Lavigne, R, Flament, D, Ladenstein, R, Myllykallio, H. | Deposit date: | 2008-01-14 | Release date: | 2009-05-19 | Last modified: | 2018-09-26 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure and function of a novel endonuclease acting on branched DNA substrates. EMBO J., 28, 2009
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2VI5
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![BU of 2vi5 by Molmil](/molmil-images/mine/2vi5) | LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO N-6-(ribitylamino)pyrimidine-2,4(1H,3H)-dione-5-yl-propionamide | Descriptor: | 1-deoxy-1-{[(5S)-2,6-dioxo-5-(propanoylamino)-1,2,5,6-tetrahydropyrimidin-4-yl]amino}-D-ribitol, 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE, PHOSPHATE ION, ... | Authors: | Morgunova, E, Zhang, Y, Jin, G, Illarionov, B, Bacher, A, Fischer, M, Cushman, M, Ladenstein, R. | Deposit date: | 2007-11-27 | Release date: | 2008-04-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A New Series of N-[2,4-Dioxo-6-D-Ribitylamino-1,2, 3,4-Tetrahydropyrimidin-5-Yl]Oxalamic Acid Derivatives as Inhibitors of Lumazine Syntase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography and Mechanistic Implications. J.Org.Chem., 73, 2008
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1N1Q
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![BU of 1n1q by Molmil](/molmil-images/mine/1n1q) | Crystal structure of a Dps protein from Bacillus brevis | Descriptor: | DPS Protein, MU-OXO-DIIRON | Authors: | Ren, B, Tibbelin, G, Kajino, T, Asami, O, Ladenstein, R. | Deposit date: | 2002-10-19 | Release date: | 2003-05-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Multi-layered Structure of Dps with a Novel Di-nuclear Ferroxidase Center J.Mol.Biol., 329, 2003
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1YK5
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![BU of 1yk5 by Molmil](/molmil-images/mine/1yk5) | Pyrococcus abyssi rubredoxin | Descriptor: | FE (III) ION, Rubredoxin | Authors: | Bonisch, H, Schmidt, C.L, Bianco, P, Ladenstein, R. | Deposit date: | 2005-01-17 | Release date: | 2006-01-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Ultrahigh-resolution study on Pyrococcus abyssi rubredoxin. I. 0.69 A X-ray structure of mutant W4L/R5S. Acta Crystallogr.,Sect.D, 61, 2005
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1SSO
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![BU of 1sso by Molmil](/molmil-images/mine/1sso) | SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS | Descriptor: | SSO7D | Authors: | Baumann, H, Knapp, S, Lundback, T, Ladenstein, R, Hard, T. | Deposit date: | 1995-03-31 | Release date: | 1995-05-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus. Nat.Struct.Biol., 1, 1994
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1SBY
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![BU of 1sby by Molmil](/molmil-images/mine/1sby) | Alcohol dehydrogenase from Drosophila lebanonensis complexed with NAD+ and 2,2,2-trifluoroethanol at 1.1 A resolution | Descriptor: | Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRIFLUOROETHANOL | Authors: | Benach, J, Meijers, R, Atrian, S, Gonzalez-Duarte, R, Lamzin, V.S, Ladenstein, R. | Deposit date: | 2004-02-11 | Release date: | 2005-02-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | 1.1-A crystal structure of D. lebanonensis ADH complexed with NAD+ and 2,2,2-trifluoroethanol To be Published
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2C4E
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![BU of 2c4e by Molmil](/molmil-images/mine/2c4e) | Crystal Structure of Methanocaldococcus jannaschii Nucleoside Kinase - An Archaeal Member of the Ribokinase Family | Descriptor: | MAGNESIUM ION, SUGAR KINASE MJ0406 | Authors: | Arnfors, L, Hansen, T, Meining, W, Schoenheit, P, Ladenstein, R. | Deposit date: | 2005-10-18 | Release date: | 2006-08-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of Methanocaldococcus Jannaschii Nucleoside Kinase: An Archaeal Member of the Ribokinase Family. Acta Crystallogr.,Sect.D, 62, 2006
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2C49
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![BU of 2c49 by Molmil](/molmil-images/mine/2c49) | Crystal Structure of Methanocaldococcus jannaschii Nucleoside Kinase - An Archaeal Member of the Ribokinase Family | Descriptor: | ADENOSINE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Arnfors, L, Hansen, T, Meining, W, Schoenheit, P, Ladenstein, R. | Deposit date: | 2005-10-17 | Release date: | 2006-08-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structure of Methanocaldococcus Jannaschii Nucleoside Kinase: An Archaeal Member of the Ribokinase Family. Acta Crystallogr.,Sect.D, 62, 2006
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2C94
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![BU of 2c94 by Molmil](/molmil-images/mine/2c94) | LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 3-(1,3,7- TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) 1,1 difluoropentane-1- PHOSPHATE | Descriptor: | 3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL) 1,1 DIFLUOROPENTANE-1-PHOSPHATE, 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE, POTASSIUM ION | Authors: | Morgunova, E, Illarionov, B, Jin, G, Haase, I, Fischer, M, Cushman, M, Bacher, A, Ladenstein, R. | Deposit date: | 2005-12-09 | Release date: | 2006-12-13 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Thermodynamic Insights Into the Binding Mode of Five Novel Inhibitors of Lumazine Synthase from Mycobacterium Tuberculosis. FEBS J., 273, 2006
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