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PDB: 1111 件

6V9C
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Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor
分子名称: Fibroblast growth factor receptor 4, N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide, SULFATE ION
著者Liu, J, Liu, H.
登録日2019-12-13
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma.
Acs Med.Chem.Lett., 11, 2020
6O1O
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BU of 6o1o by Molmil
Cryo-EM structure of the T. thermophilus Csm complex bound to target ssRNA
分子名称: Csm1, Csm2, Csm3, ...
著者Liu, J.J, Liu, T.Y.
登録日2019-02-21
公開日2019-07-10
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble.
Nat Commun, 10, 2019
4YJ5
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Crystal structure of PKM2 mutant
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, PYRUVIC ACID, ...
著者Liu, J.-S, Wu, C.-W, Wang, W.-C.
登録日2015-03-03
公開日2016-03-09
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation
Commun Biol, 2, 2019
5OWV
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An oligomerised bacterial dynamin pair provides a mechanism for the long-range sensing and tethering of membranes
分子名称: GTP-binding protein
著者Liu, J.W, Noel, J.K, Low, H.H.
登録日2017-09-04
公開日2018-09-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.72 Å)
主引用文献Structural basis for membrane tethering by a bacterial dynamin-like pair.
Nat Commun, 9, 2018
3ZP3
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INFLUENZA VIRUS (VN1194) H5 HA A138V mutant with LSTc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HAEMAGGLUTININ, N-acetyl-alpha-neuraminic acid, ...
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-26
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
3ZP1
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INFLUENZA VIRUS (VN1194) H5 HA with LSTc
分子名称: HAEMAGGLUTININ, N-acetyl-alpha-neuraminic acid-(2-2)-beta-D-galactopyranose
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-26
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
3ZP2
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INFLUENZA VIRUS (VN1194) H5 HA A138V mutant with LSTa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HAEMAGGLUTININ, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-26
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
3ZP6
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INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HAEMAGGLUTININ, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-26
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
3ZP0
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INFLUENZA VIRUS (VN1194) H5 HA with LSTa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-26
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
6U3T
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BU of 6u3t by Molmil
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: Alpha-hemolysin, SULFATE ION, fos-choline-14
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-22
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
5OXF
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BU of 5oxf by Molmil
An oligomerised bacterial dynamin pair provides a mechanism for the long range sensing and tethering of membranes
分子名称: GTP-binding protein, GUANOSINE-5'-DIPHOSPHATE
著者Liu, J.W, Noel, J.K, Low, H.H.
登録日2017-09-06
公開日2018-09-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.94 Å)
主引用文献Structural basis for membrane tethering by a bacterial dynamin-like pair.
Nat Commun, 9, 2018
3ZPA
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BU of 3zpa by Molmil
INFLUENZA VIRUS (VN1194) H5 I155F mutant HA
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ
著者Liu, J, Chen, Z, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-27
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
3ZPB
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BU of 3zpb by Molmil
INFLUENZA VIRUS (VN1194) H5 E190D mutant HA with LSTa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HAEMAGGLUTININ, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Liu, J, Stevens, D.J, Gamblin, S.J, Skehel, J.J.
登録日2013-02-27
公開日2013-10-02
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Changes in the Hemagglutinin of H5N1 Viruses During Human Infection - Influence on Receptor Binding.
Virology, 447, 2013
5G06
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BU of 5g06 by Molmil
Cryo-EM structure of yeast cytoplasmic exosome
分子名称: EXOSOME COMPLEX COMPONENT CSL4, EXOSOME COMPLEX COMPONENT MTR3, EXOSOME COMPLEX COMPONENT RRP4, ...
著者Liu, J.J, Niu, C.Y, Wu, Y, Tan, D, Wang, Y, Ye, M.D, Liu, Y, Zhao, W.W, Zhou, K, Liu, Q.S, Dai, J.B, Yang, X.R, Dong, M.Q, Huang, N, Wang, H.W.
登録日2016-03-17
公開日2016-06-15
最終更新日2017-08-02
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryoem Structure of Yeast Cytoplasmic Exosome Complex.
Cell Res., 26, 2016
6U2S
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BU of 6u2s by Molmil
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: Bi-component leukocidin LukED subunit D, fos-choline-14
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-20
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
6U33
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BU of 6u33 by Molmil
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: Bi-component leukocidin LukED subunit D, NICKEL (II) ION
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-21
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
6U3F
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BU of 6u3f by Molmil
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: Panton-Valentine Leucocidin F, SULFATE ION, fos-choline-14
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-21
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
6U4P
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BU of 6u4p by Molmil
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: Alpha-hemolysin, SULFATE ION, fos-choline-14
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-26
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
6U3Y
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BU of 6u3y by Molmil
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: ACETATE ION, Gamma-hemolysin subunit A, Panton-Valentine Leucocidin F, ...
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-22
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
6U49
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BU of 6u49 by Molmil
Structure-based discovery of a novel small-molecule inhibitor of methicillin-resistant S. aureus
分子名称: Alpha-hemolysin, SULFATE ION, fos-choline-14
著者Liu, J, Kozhaya, L, Torres, V.J, Unutmaz, D, Lu, M.
登録日2019-08-23
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure-based discovery of a small-molecule inhibitor of methicillin-resistantStaphylococcus aureusvirulence.
J.Biol.Chem., 295, 2020
8W4Q
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BU of 8w4q by Molmil
Crystal structure of PDE4D complexed with CX-4945
分子名称: 1,2-ETHANEDIOL, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, MAGNESIUM ION, ...
著者Liu, J.Y, Li, M.J, Xu, Y.C.
登録日2023-08-24
公開日2023-11-22
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.
Eur.J.Med.Chem., 262, 2023
8W4R
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BU of 8w4r by Molmil
Crystal structure of PDE4D complexed with CVT-313
分子名称: 1,2-ETHANEDIOL, 2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl]azanediyl}di(ethan-1-ol), MAGNESIUM ION, ...
著者Liu, J.Y, Li, M.J, Xu, Y.C.
登録日2023-08-24
公開日2023-11-22
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.
Eur.J.Med.Chem., 262, 2023
6PW1
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BU of 6pw1 by Molmil
Cytochrome c Oxidase delta 16
分子名称: (2S,3R)-heptane-1,2,3-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, ...
著者Liu, J, Ferguson-Miller, S.
登録日2019-07-21
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural changes at the surface of cytochrome c oxidase alter the proton-pumping stoichiometry.
Biochim Biophys Acta Bioenerg, 1861, 2019
6PW0
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Cytochrome C oxidase delta 6 mutant
分子名称: (2S,3R)-heptane-1,2,3-triol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CADMIUM ION, ...
著者Liu, J, Ferguson-Miller, S.
登録日2019-07-21
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural changes at the surface of cytochrome c oxidase alter the proton-pumping stoichiometry.
Biochim Biophys Acta Bioenerg, 1861, 2019
1P2A
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BU of 1p2a by Molmil
The structure of cyclin dependent kinase 2 (CKD2) with a trisubstituted naphthostyril inhibitor
分子名称: 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE, Cell division protein kinase 2
著者Liu, J.-J, Dermatakis, A, Lukacs, C.M, Konzelmann, F, Chen, Y, Kammlott, U, Depinto, W, Yang, H, Yin, X, Chen, Y, Schutt, A, Simcox, M.E, Luk, K.-C.
登録日2003-04-15
公開日2003-07-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors
BIOORG.MED.CHEM., 13, 2003

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