5YVD
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4BFR
| Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers | 分子名称: | 2-[2-(2-METHYL-2,3-DIHYDRO-INDOL-1-YL)-2-OXO-ETHYL]-6-MORPHOLIN-4-YL-3H-PYRIMIDIN-4-ONE, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC S SUBUNIT BETA ISOFORM | 著者 | Certal, V, Carry, J.C, Halley, F, Virone-Oddos, A, Thompson, F, Filoche-Romme, B, El-Ahmad, Y, Karlsson, A, Charrier, V, Delorme, C, Rak, A, Abecassis, P.Y, Amara, C, Vincent, L, Bonnevaux, H, Nicolas, J.P, Mathieu, M, Bertrand, T, Marquette, J.P, Michot, N, Benard, T, Perrin, M.A, Perron, S, Monget, S, Gruss-Leleu, F, Doerflinger, G, Guizani, H, Brollo, M, Delbarre, L, Bertin, L, Richepin, P, Loyau, V, Garcia-Echeverria, C, Lengauer, C, Schio, L. | 登録日 | 2013-03-22 | 公開日 | 2014-01-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery and Optimization of Pyrimidone Indoline Amide Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers. J.Med.Chem., 57, 2014
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2W31
| globin domain of Geobacter sulfurreducens globin-coupled sensor | 分子名称: | GLOBIN, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Pesce, A, Thijs, L, Nardini, M, Desmet, F, Sisinni, L, Gourlay, L, Bolli, A, Coletta, M, Van Doorslaer, S, Wan, X, Alam, M, Ascenzi, P, Moens, L, Bolognesi, M, Dewilde, S. | 登録日 | 2008-11-05 | 公開日 | 2009-01-13 | 最終更新日 | 2019-03-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Hise11 and Hisf8 Provide Bis-Histidyl Heme Hexa-Coordination in the Globin Domain of Geobacter Sulfurreducens Globin-Coupled Sensor. J.Mol.Biol., 386, 2009
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7WVK
| Crystal structure of human WDR5 in complex with compound 19 | 分子名称: | 1,2-ETHANEDIOL, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... | 著者 | Han, Q.L, Zhang, X.L, Wang, L, Ren, P.X, Cao, Y, Li, K, Bai, F. | 登録日 | 2022-02-10 | 公開日 | 2022-10-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44, 2023
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7WZ2
| SARS-CoV-2 (D614G) Spike trimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | 登録日 | 2022-02-16 | 公開日 | 2022-07-20 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer. J.Virol., 96, 2022
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7WZ1
| SARS-CoV-2 Omicron Spike trimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhan, W.Q, Zhang, X, Chen, Z.G, Sun, L. | 登録日 | 2022-02-16 | 公開日 | 2022-07-27 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer. J.Virol., 96, 2022
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7X5J
| ACP-dependent oxoacyl reductase | 分子名称: | 3-oxoacyl-ACP reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHENYLALANINE | 著者 | Wang, S, Bai, L. | 登録日 | 2022-03-04 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | ACP-dependent oxoacyl reductase To Be Published
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7WYF
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7WZB
| lipopolysaccharide assembly protein LapB (open) | 分子名称: | Lipopolysaccharide assembly protein B, TRIETHYLENE GLYCOL, ZINC ION | 著者 | Yan, L, Dong, H, Li, H, Liu, X, Deng, Z, Dong, C, Zhang, Z. | 登録日 | 2022-02-17 | 公開日 | 2023-03-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | lipopolysaccharide assembly protein LapB (open) To Be Published
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7X3O
| Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07054 | 分子名称: | (2~{R})-2-(3-fluoranyl-4-pyrimidin-5-yl-phenyl)butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | 登録日 | 2022-03-01 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07054 To Be Published
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7X3L
| Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044 | 分子名称: | (2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | 登録日 | 2022-03-01 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem., 66, 2023
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7X5B
| Crystal structure of RuvB | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Holliday junction ATP-dependent DNA helicase RuvB | 著者 | Lin, Z, Qu, Q, Zhang, X, Zhou, Z, Dai, L. | 登録日 | 2022-03-04 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa. Front Plant Sci, 14, 2023
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7X3M
| Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07045 | 分子名称: | (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | 登録日 | 2022-03-01 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.694 Å) | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J.Med.Chem., 66, 2023
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7X9Z
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7XA1
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7XA0
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7XBI
| The crystal structure of human TrkA kinase bound to the inhibitor | 分子名称: | 4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]-~{N}-[3-(1-methylpyrazol-4-yl)-1~{H}-indazol-5-yl]-2-(trifluoromethyl)benzamide, CHLORIDE ION, High affinity nerve growth factor receptor | 著者 | Wu, C.Y, Wang, G, Ouyang, L. | 登録日 | 2022-03-21 | 公開日 | 2023-03-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | The crystal structure of human TrkA kinase bound to the inhibitor To be published
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5FTQ
| Crystal structure of the ALK kinase domain in complex with Cmpd 17 | 分子名称: | ALK TYROSINE KINASE RECEPTOR, GLYCEROL, N-[5-(3,5-DIFLUOROBENZYL)-1H-INDAZOL-3-YL]-2-[(4-HYDROXYCYCLOHEXYL)AMINO]-4-(4-METHYLPIPERAZIN-1-YL) BENZAMIDE | 著者 | Bossi, R, Canevari, G, Fasolini, M, Menichincheri, M, Ardini, E, Magnaghi, P, Avanzi, N, Banfi, P, Buffa, L, Ceriani, L, Colombo, M, Corti, L, Donati, D, Felder, E, Fiorelli, C, Fiorentini, F, Galvani, A, Isacchi, A, Lombardi Borgia, A, Marchionni, C, Nesi, M, Orrenius, C, Panzeri, A, Perrone, E, Pesenti, E, Rusconi, L, Saccardo, M.B, Vanotti, E, Orsini, P. | 登録日 | 2016-01-14 | 公開日 | 2016-04-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (Alk), C-Ros Oncogene 1 Kinase (Ros1), and Pan-Tropomyosin Receptor Kinases (Pan-Trks) Inhibitor. J.Med.Chem., 59, 2016
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7XFG
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7X1Z
| Structure of the phosphorylation-site double mutant S431E/T432E of the KaiC circadian clock protein | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION | 著者 | Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q. | 登録日 | 2022-02-25 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex Nat Commun, 14, 2023
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7XEZ
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7XI6
| Crystal structure of C56 from pSSVi | 分子名称: | C56 | 著者 | Zhang, Z.F, Ren, Y, Chen, Y.Y, Zhang, X.W, Dong, Y.H, Gong, Y, Cao, P, Huang, L. | 登録日 | 2022-04-12 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Characterization of the AbrB-like protein C56 conserved in a novel family of integrated genetic elements in Sulfolobales To Be Published
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7XFN
| Structure of nucleosome-DI complex (-55I, Apo state) | 分子名称: | DNA (152-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Zheng, L, Tsai, B, Gao, N. | 登録日 | 2022-04-01 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome. Cell Discov, 9, 2023
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7XFL
| Structure of nucleosome-AAG complex (A-53I, free state) | 分子名称: | DNA (152-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Zheng, L, Tsai, B, Gao, N. | 登録日 | 2022-04-01 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome. Cell Discov, 9, 2023
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7XFM
| Structure of nucleosome-AAG complex (A-53I, post-catalytic state) | 分子名称: | DNA (152-MER), DNA-3-methyladenine glycosylase, Histone H2A type 1, ... | 著者 | Zheng, L, Tsai, B, Gao, N. | 登録日 | 2022-04-01 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural and mechanistic insights into the DNA glycosylase AAG-mediated base excision in nucleosome. Cell Discov, 9, 2023
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