2GS6
| Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate | Descriptor: | CHLORIDE ION, Epidermal growth factor receptor, Peptide, ... | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | Deposit date: | 2006-04-25 | Release date: | 2006-06-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor Cell(Cambridge,Mass.), 125, 2006
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1XDV
| Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. | Descriptor: | Son of sevenless protein homolog 1 | Authors: | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | Deposit date: | 2004-09-08 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structural analysis of autoinhibition in the ras activator son of sevenless. Cell(Cambridge,Mass.), 119, 2004
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1IAJ
| CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO) | Descriptor: | TRANSIENT RECEPTOR POTENTIAL-RELATED PROTEIN, ZINC ION | Authors: | Yamaguchi, H, Matsushita, M, Nairn, A.C, Kuriyan, J. | Deposit date: | 2001-03-22 | Release date: | 2001-06-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol.Cell, 7, 2001
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1BGF
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1IA9
| CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (AMPPNP COMPLEX) | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TRANSIENT RECEPTOR POTENTIAL-RELATED PROTEIN, ... | Authors: | Yamaguchi, H, Matsushita, M, Nairn, A.C, Kuriyan, J. | Deposit date: | 2001-03-22 | Release date: | 2001-06-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol.Cell, 7, 2001
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2F4J
| Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680 | Descriptor: | CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, Proto-oncogene tyrosine-protein kinase ABL1 | Authors: | Young, M.A, Shah, N.P, Chao, L.H, Zarrinkar, P, Sawyers, P, Kuriyan, J. | Deposit date: | 2005-11-23 | Release date: | 2006-01-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res., 66, 2006
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1B6C
| CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12 | Descriptor: | FK506-BINDING PROTEIN, SULFATE ION, TGF-B SUPERFAMILY RECEPTOR TYPE I | Authors: | Huse, M, Chen, Y.-G, Massague, J, Kuriyan, J. | Deposit date: | 1999-01-13 | Release date: | 1999-06-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell(Cambridge,Mass.), 96, 1999
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3G6G
| Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations | Descriptor: | GLYCEROL, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, Proto-oncogene tyrosine-protein kinase Src | Authors: | Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J. | Deposit date: | 2009-02-06 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations Cancer Res., 69, 2009
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3G6H
| Src Thr338Ile inhibited in the DFG-Asp-Out conformation | Descriptor: | N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide, Proto-oncogene tyrosine-protein kinase Src | Authors: | Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J. | Deposit date: | 2009-02-06 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations Cancer Res., 69, 2009
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1SHB
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1SHA
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3EEE
| Probing the function of heme distortion in the H-NOX family | Descriptor: | CHLORIDE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | Authors: | Olea Jr, C, Boon, E.M, Pellicena, P, Kuriyan, J, Marletta, M.A. | Deposit date: | 2008-09-04 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Probing the function of heme distortion in the H-NOX family. Acs Chem.Biol., 3, 2008
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1U4H
| Crystal structure of an oxygen binding H-NOX domain related to soluble guanylate cyclases (oxygen complex) | Descriptor: | GLYCEROL, Heme-based Methyl-accepting Chemotaxis Protein, OXYGEN MOLECULE, ... | Authors: | Pellicena, P, Karow, D.S, Boon, E.M, Marletta, M.A, Kuriyan, J. | Deposit date: | 2004-07-25 | Release date: | 2004-08-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc.Natl.Acad.Sci.Usa, 101, 2004
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1SXJ
| Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Activator 1 37 kDa subunit, Activator 1 40 kDa subunit, ... | Authors: | Bowman, G.D, O'Donnell, M, Kuriyan, J. | Deposit date: | 2004-03-30 | Release date: | 2004-06-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex. Nature, 429, 2004
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3DQW
| c-Src kinase domain Thr338Ile mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Proto-oncogene tyrosine-protein kinase Src | Authors: | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | Deposit date: | 2008-07-09 | Release date: | 2008-09-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.017 Å) | Cite: | Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat.Struct.Mol.Biol., 15, 2008
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1SPS
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2HNH
| Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III | Descriptor: | DNA polymerase III alpha subunit, PHOSPHATE ION | Authors: | Meindert, M.H, Georgescu, R.E, Lee, S, O'Donnell, M, Kuriyan, J. | Deposit date: | 2006-07-12 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Catalytic alpha Subunit of E. coli Replicative DNA Polymerase III. Cell(Cambridge,Mass.), 126, 2006
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1NJF
| Nucleotide bound form of an isolated E. coli clamp loader gamma subunit | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA polymerase III subunit gamma, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Podobnik, M, Weitze, T.F, O'Donnell, M, Kuriyan, J. | Deposit date: | 2002-12-30 | Release date: | 2003-04-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit Structure, 11, 2003
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1NVV
| Structural evidence for feedback activation by RasGTP of the Ras-specific nucleotide exchange factor SOS | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Margarit, S.M, Sondermann, H, Hall, B.E, Nagar, B, Hoelz, A, Pirruccello, M, Bar-Sagi, D, Kuriyan, J. | Deposit date: | 2003-02-04 | Release date: | 2003-04-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structural evidence for feedback activation by RasGTP of the
Ras-specific nucleotide exchange factor SOS Cell(Cambridge,Mass.), 112, 2003
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3D7U
| Structural basis for the recognition of c-Src by its inactivator Csk | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, Tyrosine-protein kinase CSK | Authors: | Levinson, N.M, Seeliger, M.A, Cole, P.A, Kuriyan, J. | Deposit date: | 2008-05-21 | Release date: | 2008-08-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.111 Å) | Cite: | Structural basis for the recognition of c-Src by its inactivator Csk. Cell(Cambridge,Mass.), 134, 2008
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1EM8
| Crystal structure of chi and psi subunit heterodimer from DNA POL III | Descriptor: | DNA POLYMERASE III CHI SUBUNIT, DNA POLYMERASE III PSI SUBUNIT | Authors: | Gulbis, J.M, Finkelstein, J, O'Donnell, M, Kuriyan, J. | Deposit date: | 2000-03-16 | Release date: | 2003-08-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the chi:psi sub-assembly of the Escherichia coli DNA polymerase clamp-loader complex. Eur.J.Biochem., 271, 2004
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3TF1
| Crystal structure of an H-NOX protein from T. tengcongensis under 6 atm of xenon | Descriptor: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.0369 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3D7T
| Structural basis for the recognition of c-Src by its inactivator Csk | Descriptor: | Proto-oncogene tyrosine-protein kinase Src, STAUROSPORINE, Tyrosine-protein kinase CSK | Authors: | Levinson, N.M, Seeliger, M.A, Cole, P.A, Kuriyan, J. | Deposit date: | 2008-05-21 | Release date: | 2008-08-05 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.899 Å) | Cite: | Structural basis for the recognition of c-Src by its inactivator Csk. Cell(Cambridge,Mass.), 134, 2008
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3TFA
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 6 atm of xenon | Descriptor: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, XENON | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2711 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF9
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 under 1 atm of xenon | Descriptor: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5901 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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