2WWZ
 
 | | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P212121 | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | | 著者 | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | | 登録日 | 2009-10-30 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
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3ZJF
 | | A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak. | | 分子名称: | A20P50, CHLORIDE ION | | 著者 | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | | 登録日 | 2013-01-17 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
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3ZJG
 | | A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak. | | 分子名称: | CHLORIDE ION, TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3 | | 著者 | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | | 登録日 | 2013-01-17 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
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3ZJD
 | | A20 OTU domain in reduced, active state at 1.87 A resolution | | 分子名称: | 1,2-ETHANEDIOL, A20P50, CHLORIDE ION | | 著者 | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | | 登録日 | 2013-01-17 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
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3ZJE
 | | A20 OTU domain in reversibly oxidised (SOH) state | | 分子名称: | 1,2-ETHANEDIOL, A20P50, CHLORIDE ION | | 著者 | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | | 登録日 | 2013-01-17 | | 公開日 | 2013-03-06 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
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2WX0
 | | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21 | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | | 著者 | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | | 登録日 | 2009-10-30 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
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2WX1
 | | TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked tri-ubiquitin, P212121 | | 分子名称: | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION | | 著者 | Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D. | | 登録日 | 2009-10-30 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
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8A67
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8C0D
 | | UFL1/DDRGK1 bound to UFC1 | | 分子名称: | DDRGK domain-containing protein 1, E3 UFM1-protein ligase 1, Ubiquitin-fold modifier-conjugating enzyme 1 | | 著者 | Magnussen, H.M, Kulathu, Y. | | 登録日 | 2022-12-16 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.564 Å) | | 主引用文献 | The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
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8BZR
 | | UFC1-UFM1 conjugate | | 分子名称: | 1,2-ETHANEDIOL, Ubiquitin-fold modifier 1, Ubiquitin-fold modifier-conjugating enzyme 1 | | 著者 | Magnussen, H.M, Kulathu, Y. | | 登録日 | 2022-12-15 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.781 Å) | | 主引用文献 | The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
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6FGE
 | | Crystal structure of human ZUFSP/ZUP1 in complex with ubiquitin | | 分子名称: | ACETATE ION, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Kwasna, D, Abdul Rehman, S.A, Kulathu, Y. | | 登録日 | 2018-01-10 | | 公開日 | 2018-04-04 | | 最終更新日 | 2018-04-18 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.
Mol. Cell, 70, 2018
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6RUU
 | | Pseudokinase domain of human IRAK3 | | 分子名称: | GLYCEROL, Interleukin-1 receptor-associated kinase 3, MERCURY (II) ION, ... | | 著者 | Lange, S.M, Kulathu, Y, Cohen, P. | | 登録日 | 2019-05-29 | | 公開日 | 2020-09-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation.
Structure, 29, 2021
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6TUV
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6TXB
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8QFD
 | | UFL1 E3 ligase bound 60S ribosome | | 分子名称: | 28S rRNA, 5.8S rRNA, 5S rRNA, ... | | 著者 | Makhlouf, L, Kulathu, Y, Zeqiraj, E. | | 登録日 | 2023-09-04 | | 公開日 | 2024-02-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Nature, 627, 2024
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6Z49
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6Z7V
 | | Crystal structure of Mindy2 (C266A) in complex with Lys48 linked di-ubiquitin (K48-Ub2) | | 分子名称: | POTASSIUM ION, Polyubiquitin-C, TETRAETHYLENE GLYCOL, ... | | 著者 | Abdul Rehman, S.A, Lange, S.M, Kulathu, Y. | | 登録日 | 2020-06-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Mol.Cell, 81, 2021
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6Z90
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4Y1H
 | | Crystal structure of K33 linked tri-Ubiquitin | | 分子名称: | 1,2-ETHANEDIOL, Ubiquitin-40S ribosomal protein S27a | | 著者 | Kristariyanto, Y.A, Abdul Rehman, S.A, Choi, S.Y, Ritorto, S, Campbell, D.G, Morrice, N.A, Toth, R, Kulathu, Y. | | 登録日 | 2015-02-07 | | 公開日 | 2015-03-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem.J., 467, 2015
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4XYZ
 | | Crystal structure of K33 linked di-Ubiquitin | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, IODIDE ION, ... | | 著者 | Kristariyanto, Y.A, Abdul Rehman, S.A, Choi, S.Y, Ritorto, S, Campbell, D.G, Morrice, N.A, Toth, R, Kulathu, Y. | | 登録日 | 2015-02-03 | | 公開日 | 2015-03-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.
Biochem.J., 467, 2015
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3ZNX
 | | Crystal structure of the OTU domain of OTULIN D336A mutant | | 分子名称: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | | 登録日 | 2013-02-18 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
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3ZNH
 | | Crimean Congo Hemorrhagic Fever Virus OTU domain in complex with ubiquitin-propargyl. | | 分子名称: | POLYUBIQUITIN-B, UBIQUITIN THIOESTERASE | | 著者 | Ekkebus, R, vanKasteren, S.I, Kulathu, Y, Scholten, A, Berlin, I, deJong, A, Goerdayal, G, Neefjes, J, Heck, A.J.R, Komander, D, Ovaa, H. | | 登録日 | 2013-02-14 | | 公開日 | 2013-02-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | On Terminal Alkynes that Can React with Active-Site Cysteine Nucleophiles in Proteases.
J.Am.Chem.Soc., 135, 2013
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3ZNZ
 | | Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin | | 分子名称: | POLYUBIQUITIN-C, PROTEIN FAM105B, SULFATE ION | | 著者 | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | | 登録日 | 2013-02-18 | | 公開日 | 2013-06-26 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
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3ZNV
 | | Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms. | | 分子名称: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | | 登録日 | 2013-02-18 | | 公開日 | 2013-06-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
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4S1Z
 | | Crystal structure of TRABID NZF1 in complex with K29 linked di-Ubiquitin | | 分子名称: | Ubiquitin, Ubiquitin thioesterase ZRANB1, ZINC ION | | 著者 | Kristariyanto, Y.A, Abdul Rehman, S.A, Campbell, D.G, Morrice, N.A, Johnson, C, Toth, R, Kulathu, Y. | | 登録日 | 2015-01-16 | | 公開日 | 2015-04-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | | 主引用文献 | K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Mol.Cell, 58, 2015
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