7RUT
 
 | | Structure of Human ATP:Cobalamin Adenosyltransferase R190C bound to ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Corrinoid adenosyltransferase, GLYCEROL, ... | | 著者 | Mascarenhas, R, Gouda, H, Koutmos, M, Banerjee, R. | | 登録日 | 2021-08-18 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions.
J.Biol.Chem., 297, 2021
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7RUV
 | | Structure of Human ATP:Cobalamin Adenosyltransferase E193K bound to adenosylcobalamin | | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, Corrinoid adenosyltransferase, ... | | 著者 | Mascarenhas, R, Gouda, H, Koutmos, M, Banerjee, R. | | 登録日 | 2021-08-18 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Patient mutations in human ATP:cob(I)alamin adenosyltransferase differentially affect its catalytic versus chaperone functions.
J.Biol.Chem., 297, 2021
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6XJJ
 | | Structure of non-heme iron enzyme TropC: Radical tropolone biosynthesis | | 分子名称: | 2-oxoglutarate-dependent dioxygenase tropC, ACETATE ION, FE (III) ION, ... | | 著者 | Mallik, L, Doyon, T.J, Narayan, A.R.H, Koutmos, M. | | 登録日 | 2020-06-24 | | 公開日 | 2021-06-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Radical Tropolone Biosynthesis
Chemrxiv, 2020
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6U1R
 | | SxtG an amidinotransferase from the Microseira wollei in Saxitoxin biosynthetic pathway | | 分子名称: | FORMIC ACID, SxtG | | 著者 | Mallik, L, Lukowski, A.L, Narayan, A.R.H, Koutmos, M. | | 登録日 | 2019-08-16 | | 公開日 | 2020-03-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.792 Å) | | 主引用文献 | Substrate Promiscuity of a Paralytic Shellfish Toxin Amidinotransferase.
Acs Chem.Biol., 15, 2020
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8UY2
 | | Methylenetetrahydrofolate reductase from Chaetomium thermophilum DSM 1495, AdoMet-bound, Inhibited (T) State | | 分子名称: | ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Yamada, K, Mendoza, J, Koutmos, M. | | 登録日 | 2023-11-12 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase.
Nat Commun, 15, 2024
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8UY1
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8D32
 | | Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase bound to 5-deoxyadenosylrhodibalamin and PPPi | | 分子名称: | 5'-DEOXYADENOSINE, Corrinoid adenosyltransferase, MAGNESIUM ION, ... | | 著者 | Mascarenhas, R.N, Ruetz, M, Koutmos, M, Banerjee, R. | | 登録日 | 2022-05-31 | | 公開日 | 2023-05-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A noble substitution leads to the cofactor mimicry by rhodibalamin
To Be Published
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7TH5
 | | Thermus thermophilus methylenetetrahydrofolate reductase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase, SODIUM ION | | 著者 | Yamada, K, Koutmos, M. | | 登録日 | 2022-01-10 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity.
J.Biol.Chem., 299, 2022
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7TH4
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8EAC
 | | Thermus thermophilus methylenetetrahydrofolate reductase | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase | | 著者 | Yamada, K, Koutmos, M. | | 登録日 | 2022-08-28 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity.
J.Biol.Chem., 299, 2022
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8SSG
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8SSE
 | | Methionine synthase, C-terminal fragment, Cobalamin and Reactivation Domains from Thermus thermophilus HB8 | | 分子名称: | COBALAMIN, Methionine synthase | | 著者 | Yamada, K, Mendoza, J, Koutmos, M. | | 登録日 | 2023-05-08 | | 公開日 | 2023-10-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo.
Nat Commun, 14, 2023
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3IV9
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8SSF
 | | Minimal protein-only/RNA-free Ribonuclease P from Hydrogenobacter thermophilus | | 分子名称: | RNA-free ribonuclease P, SULFATE ION | | 著者 | Mendoza, J, Mallik, L, Wilhelm, C.A, Koutmos, M. | | 登録日 | 2023-05-08 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Bacterial RNA-free RNase P: Structural and functional characterization of multiple oligomeric forms of a minimal protein-only ribonuclease P.
J.Biol.Chem., 299, 2023
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8SSC
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8SSD
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3IVA
 | | Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half with AdoHcy bound | | 分子名称: | COBALAMIN, Methionine synthase, NITRATE ION, ... | | 著者 | Pattridge, K.A, Koutmos, M, Smith, J.L. | | 登録日 | 2009-08-31 | | 公開日 | 2009-11-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Insights into the reactivation of cobalamin-dependent methionine synthase.
Proc.Natl.Acad.Sci.USA, 106, 2009
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6WH5
 | | Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase bound to cob(II)alamin and PPPi | | 分子名称: | COBALAMIN, Corrinoid adenosyltransferase, MAGNESIUM ION, ... | | 著者 | Mascarenhas, R.N, Ruetz, M, Koutmos, M, Banerjee, R. | | 登録日 | 2020-04-07 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.866 Å) | | 主引用文献 | Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B 12 .
Proc.Natl.Acad.Sci.USA, 117, 2020
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5DIZ
 | | Crystal Structure of nuclear proteinaceous RNase P 2 (PRORP2) from A. thaliana | | 分子名称: | Proteinaceous RNase P 2, ZINC ION | | 著者 | Karasik, A, Shanmuganathan, A, Howard, M.J, Fierke, C.A, Koutmos, M. | | 登録日 | 2015-09-01 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Nuclear Protein-Only Ribonuclease P2 Structure and Biochemical Characterization Provide Insight into the Conserved Properties of tRNA 5' End Processing Enzymes.
J.Mol.Biol., 428, 2016
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6WGU
 | | Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase | | 分子名称: | Corrinoid adenosyltransferase, SULFATE ION | | 著者 | Mascarenhas, R.N, Ruetz, M, Koutmos, M, Banerjee, R. | | 登録日 | 2020-04-06 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B 12 .
Proc.Natl.Acad.Sci.USA, 117, 2020
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6WGV
 | | Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase bound to adenosylcobalamin and PPPi | | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, Corrinoid adenosyltransferase, ... | | 著者 | Mascarenhas, R.N, Ruetz, M, Koutmos, M, Banerjee, R. | | 登録日 | 2020-04-06 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | | 主引用文献 | Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B 12 .
Proc.Natl.Acad.Sci.USA, 117, 2020
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6WGS
 | | Mycobacterium tuberculosis pduO-type ATP:cobalamin adenosyltransferase bound to adenosylcobalamin | | 分子名称: | 5'-DEOXYADENOSINE, COBALAMIN, Corrinoid adenosyltransferase | | 著者 | Mascarenhas, R.N, Ruetz, M, Koutmos, M, Banerjee, R. | | 登録日 | 2020-04-06 | | 公開日 | 2021-01-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B 12 .
Proc.Natl.Acad.Sci.USA, 117, 2020
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5CV0
 | | Crystal structure of N-terminal truncated human B12-chaperone CblD (108-296) | | 分子名称: | Methylmalonic aciduria and homocystinuria type D protein, mitochondrial | | 著者 | Yamada, K, Gherasim, C, Banerjee, R, Koutmos, M. | | 登録日 | 2015-07-24 | | 公開日 | 2015-09-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases.
J.Biol.Chem., 290, 2015
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5CUZ
 | | Crystal structure of SeMet-substituted N-terminal truncated human B12-chaperone CblD (108-296) | | 分子名称: | Methylmalonic aciduria and homocystinuria type D protein, mitochondrial | | 著者 | Yamada, K, Gherasim, C, Banerjee, R, Koutmos, M. | | 登録日 | 2015-07-25 | | 公開日 | 2015-09-23 | | 最終更新日 | 2015-12-16 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases.
J.Biol.Chem., 290, 2015
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5UOS
 | | Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12 | | 分子名称: | 1-ethynyl-2,4-difluorobenzene, 2-PHENYLAMINO-ETHANESULFONIC ACID, COBALAMIN, ... | | 著者 | Shanmuganathan, A, Karasik, A, Ruetz, M, Banerjee, R, Krautler, B, Koutmos, M. | | 登録日 | 2017-02-01 | | 公開日 | 2017-06-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | | 主引用文献 | Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate.
Angew. Chem. Int. Ed. Engl., 56, 2017
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