5UOS

Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12

Summary for 5UOS

Entry DOI	10.2210/pdb5uos/pdb
Descriptor	Methylmalonic aciduria and homocystinuria type C protein, COBALAMIN, 1-ethynyl-2,4-difluorobenzene, ... (8 entities in total)
Functional Keywords	vitamin b12, oxidoreductase, b12 trafficking, b12 processing, b12 binding
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9Y4U1
Total number of polymer chains	1
Total formula weight	29681.66
Authors	Shanmuganathan, A.,Karasik, A.,Ruetz, M.,Banerjee, R.,Krautler, B.,Koutmos, M. (deposition date: 2017-02-01, release date: 2017-06-07, Last modification date: 2023-10-04)
Primary citation	Ruetz, M.,Shanmuganathan, A.,Gherasim, C.,Karasik, A.,Salchner, R.,Kieninger, C.,Wurst, K.,Banerjee, R.,Koutmos, M.,Krautler, B. Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate. Angew. Chem. Int. Ed. Engl., 56:7387-7392, 2017 Cited by PubMed: 28544088 DOI: 10.1002/anie.201701583 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.51 Å)

Structure validation