5UOS
Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue B12 A 301 |
| Chain | Residue |
| A | LEU34 |
| A | GLN131 |
| A | ARG144 |
| A | SER146 |
| A | VAL148 |
| A | CYS149 |
| A | ILE160 |
| A | PHE196 |
| A | TRP200 |
| A | 8FS302 |
| A | HOH403 |
| A | LEU35 |
| A | HOH405 |
| A | HOH418 |
| A | HOH424 |
| A | PRO36 |
| A | ASP104 |
| A | ILE115 |
| A | ALA117 |
| A | GLN118 |
| A | HIS122 |
| A | TYR129 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue 8FS A 302 |
| Chain | Residue |
| A | B12301 |
| A | GSH303 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue GSH A 303 |
| Chain | Residue |
| A | ASP77 |
| A | PRO78 |
| A | VAL79 |
| A | ASP80 |
| A | PHE158 |
| A | ARG161 |
| A | ARG206 |
| A | TYR215 |
| A | PHE223 |
| A | ARG230 |
| A | 8FS302 |
| A | HOH412 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue 171 A 304 |
| Chain | Residue |
| A | ALA84 |
| A | ARG91 |
| A | GLU100 |
| A | ILE101 |
| A | GLU106 |
| A | NA307 |
| A | NA307 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | GLU136 |
| A | ALA137 |
| A | ASP138 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | ALA137 |
| A | PRO139 |
| A | ARG186 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 307 |
| Chain | Residue |
| A | ARG91 |
| A | 171304 |
| A | 171304 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21697092","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22642810","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SOM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
