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PDB: 101 results

6U1S
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BU of 6u1s by Molmil
Cryo-EM structure of a de novo designed 16-helix transmembrane nanopore, TMHC8_R.
Descriptor: de novo designed 16-helix transmembrane nanopore, TMHC8_R
Authors:Johnson, M.J, Reggiano, G, Xu, C, Lu, P, Hsia, Y, Brunette, T.J, DiMaio, F, Baker, D, Kollman, J.
Deposit date:2019-08-16
Release date:2020-08-19
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Computational Design of Transmembrane Channels
To Be Published
7MII
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BU of 7mii by Molmil
Human CTPS2 bound to inhibitor T35
Descriptor: 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide, CTP synthase 2, GLUTAMINE, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-16
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MH1
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BU of 7mh1 by Molmil
Human CTPS2 bound to CTP
Descriptor: CTP synthase 2, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Lynch, E.M, Kollman, J.M.
Deposit date:2021-04-14
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIF
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BU of 7mif by Molmil
Human CTPS1 bound to inhibitor R80
Descriptor: CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-16
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MGZ
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BU of 7mgz by Molmil
Human CTPS1 bound to UTP, AMPPNP, and glutamine
Descriptor: CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-14
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIU
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BU of 7miu by Molmil
Mouse CTPS2 bound to inhibitor R80
Descriptor: CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-17
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIP
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BU of 7mip by Molmil
Mouse CTPS1 bound to inhibitor R80
Descriptor: CTP synthase 1, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-17
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
6BQW
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BU of 6bqw by Molmil
AlfA Filament bound to AMPPNP
Descriptor: Bacterial actin AlfA, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Usluer, G.D, Kollman, J.M, DiMaio, F.
Deposit date:2017-11-28
Release date:2018-02-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structure of the bacterial actin AlfA reveals unique assembly and ATP-binding interactions and the absence of a conserved subdomain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7MH0
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BU of 7mh0 by Molmil
Human CTPS1 bound to CTP
Descriptor: CTP synthase 1, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Lynch, E.M, Kollman, J.M.
Deposit date:2021-04-14
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIH
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BU of 7mih by Molmil
Human CTPS2 bound to inhibitor R80
Descriptor: CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-16
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIV
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BU of 7miv by Molmil
Mouse CTPS2-I250T bound to inhibitor R80
Descriptor: CTP synthase 2, GLUTAMINE, MAGNESIUM ION, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-17
Release date:2021-10-13
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MIG
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BU of 7mig by Molmil
Human CTPS1 bound to inhibitor T35
Descriptor: 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide, CTP synthase 1, GLUTAMINE, ...
Authors:Lynch, E.M, Dimattia, M.A, Kollman, J.M.
Deposit date:2021-04-16
Release date:2021-10-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for isoform-specific inhibition of human CTPS1.
Proc.Natl.Acad.Sci.USA, 118, 2021
7RMK
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BU of 7rmk by Molmil
Yeast CTP Synthase (Ura7) Bundle bound to substrates at low pH
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, URIDINE 5'-TRIPHOSPHATE
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-27
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RMF
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BU of 7rmf by Molmil
Substrate-bound Ura7 filament at low pH
Descriptor: CTP synthase
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-27
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RNL
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BU of 7rnl by Molmil
Yeast CTP Synthase (Ura7) H360R Filament bound to Substrates
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-29
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RMO
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BU of 7rmo by Molmil
Yeast CTP Synthase (Ura7) Bundle bound to Products at low pH
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-27
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RNR
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BU of 7rnr by Molmil
Yeast CTP Synthase (Ura8) Bundle Bound to Substrates at Low pH
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, MAGNESIUM ION, ...
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-29
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
6U9O
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BU of 6u9o by Molmil
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Fully compressed filament segment reconstruction.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ...
Authors:Johnson, M.C, Kollman, J.M.
Deposit date:2019-09-09
Release date:2020-03-25
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation.
Elife, 9, 2020
6UA2
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BU of 6ua2 by Molmil
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (2/4 compressed, 2/4 extended) segment reconstruction.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ...
Authors:Johnson, M.C, Kollman, J.M.
Deposit date:2019-09-10
Release date:2020-03-25
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation.
Elife, 9, 2020
7RL5
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BU of 7rl5 by Molmil
Yeast CTP Synthase (URA8) filament bound to CTP at low pH
Descriptor: CTP synthase, CYTIDINE-5'-TRIPHOSPHATE
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-23
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RMV
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BU of 7rmv by Molmil
Yeast CTP Synthase (Ura7) H360R Filament bound to Substrates
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, URIDINE 5'-TRIPHOSPHATE
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-28
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RL0
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BU of 7rl0 by Molmil
Yeast CTP Synthase (URA8) Filament bound to ATP/UTP at low pH
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, MAGNESIUM ION, ...
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-22
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RMC
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BU of 7rmc by Molmil
Yeast CTP Synthase (Ura7) filament bound to CTP at low pH
Descriptor: CTP synthase 1, CYTIDINE-5'-TRIPHOSPHATE
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-27
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RKH
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BU of 7rkh by Molmil
Yeast CTP Synthase (URA8) tetramer bound to ATP/UTP at neutral pH
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, MAGNESIUM ION, ...
Authors:Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M.
Deposit date:2021-07-22
Release date:2021-11-24
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
7RES
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BU of 7res by Molmil
HUMAN IMPDH1 TREATED WITH ATP, IMP, AND NAD+, OCTAMER-CENTERED
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1, ...
Authors:Burrell, A.L, Kollman, J.M.
Deposit date:2021-07-13
Release date:2022-01-12
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
Nat.Struct.Mol.Biol., 29, 2022

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PDB entries from 2024-06-12

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