6U9O
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Fully compressed filament segment reconstruction.
Summary for 6U9O
Entry DOI | 10.2210/pdb6u9o/pdb |
Related | 6U8E 6U8N 6U8R 6U8S |
EMDB information | 20687 20688 20690 20691 20701 |
Descriptor | Inosine-5'-monophosphate dehydrogenase 2, GUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | metabolism, filament, allostery, adenine, guanine, biosynthetic protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 16 |
Total formula weight | 924209.38 |
Authors | Johnson, M.C.,Kollman, J.M. (deposition date: 2019-09-09, release date: 2020-03-25, Last modification date: 2024-03-20) |
Primary citation | Johnson, M.C.,Kollman, J.M. Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9:-, 2020 Cited by PubMed: 31999252DOI: 10.7554/eLife.53243 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.36 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)