6U9O
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Fully compressed filament segment reconstruction.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, I, B, J, C...) | Inosine-5'-monophosphate dehydrogenase 2 | polymer | 519 | 56480.5 | 16 | UniProt (P12268) Pfam (PF00478) Pfam (PF00571) | Homo sapiens (Human) | IMPDH 2,IMPDH-II |
| 2 | AA, AB, BA, FA, GA... (C, H, D, E, F...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 16 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 3 | BB, CA, HA, MA, RA... (H, C, D, E, F...) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 8 | Chemie (ATP) | |||
| 4 | CB, DA, IA, NA, SA... (H, C, D, E, F...) | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734) | |||
| 5 | DB, EA, JA, OA, TA... (H, C, D, E, F...) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) |
Sequence modifications
A, I, B, J, C, K, D, L, E, M, F, N, G, O, H, P: 1 - 514 (UniProt: P12268)
| PDB | External Database | Details |
|---|---|---|
| Ser -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Leu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 903688.0 | |
| Non-Polymers* | Number of molecules | 40 |
| Total formula weight | 20521.4 | |
| All* | Total formula weight | 924209.4 |
