6U9O
Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Fully compressed filament segment reconstruction.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, I, B, J, C...) | Inosine-5'-monophosphate dehydrogenase 2 | polymer | 519 | 56480.5 | 16 | UniProt (P12268) Pfam (PF00478) Pfam (PF00571) | Homo sapiens (Human) | IMPDH 2,IMPDH-II |
| 2 | AA, AB, BA, FA, GA... (C, H, D, E, F...) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 16 | Chemie (GTP) | |||
| 3 | BB, CA, HA, MA, RA... (H, C, D, E, F...) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 8 | Chemie (ATP) | |||
| 4 | CB, DA, IA, NA, SA... (H, C, D, E, F...) | INOSINIC ACID | non-polymer | 348.2 | 8 | Chemie (IMP) | |||
| 5 | DB, EA, JA, OA, TA... (H, C, D, E, F...) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 8 | Chemie (NAD) |
Sequence modifications
A, I, B, J, C, K, D, L, E, M, F, N, G, O, H, P: 1 - 514 (UniProt: P12268)
| PDB | External Database | Details |
|---|---|---|
| Ser -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Leu 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 903688.0 | |
| Non-Polymers* | Number of molecules | 40 |
| Total formula weight | 20521.4 | |
| All* | Total formula weight | 924209.4 |
