7MGZ

Human CTPS1 bound to UTP, AMPPNP, and glutamine

Summary for 7MGZ

• Entry DOI: 10.2210/pdb7mgz/pdb
• EMDB information: 23831
• Descriptor: CTP synthase 1, URIDINE 5'-TRIPHOSPHATE, GLUTAMINE, ... (5 entities in total)
• Functional Keywords: glutaminase, amidoligase, nucleotide metabolism, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 271849.55

Authors

Lynch, E.M.,Dimattia, M.A.,Kollman, J.M. (deposition date: 2021-04-14, release date: 2021-10-13)

• Primary citation: Lynch, E.M.,DiMattia, M.A.,Albanese, S.,van Zundert, G.C.P.,Hansen, J.M.,Quispe, J.D.,Kennedy, M.A.,Verras, A.,Borrelli, K.,Toms, A.V.,Kaila, N.,Kreutter, K.D.,McElwee, J.J.,Kollman, J.M.; Structural basis for isoform-specific inhibition of human CTPS1.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34583994; DOI: 10.1073/pnas.2107968118

Experimental method

ELECTRON MICROSCOPY (2.8 Å)