Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7MGZ

Human CTPS1 bound to UTP, AMPPNP, and glutamine

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0002376	biological_process	immune system process
F	0003883	molecular_function	CTP synthase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0009410	biological_process	response to xenobiotic stimulus
F	0016020	cellular_component	membrane
F	0016874	molecular_function	ligase activity
F	0019637	biological_process	organophosphate metabolic process
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0042098	biological_process	T cell proliferation
F	0042100	biological_process	B cell proliferation
F	0042802	molecular_function	identical protein binding
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0097268	cellular_component	cytoophidium
O	0002376	biological_process	immune system process
O	0003883	molecular_function	CTP synthase activity
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006139	biological_process	nucleobase-containing compound metabolic process
O	0006221	biological_process	pyrimidine nucleotide biosynthetic process
O	0006241	biological_process	CTP biosynthetic process
O	0006541	biological_process	glutamine metabolic process
O	0009410	biological_process	response to xenobiotic stimulus
O	0016020	cellular_component	membrane
O	0016874	molecular_function	ligase activity
O	0019637	biological_process	organophosphate metabolic process
O	0019856	biological_process	pyrimidine nucleobase biosynthetic process
O	0042098	biological_process	T cell proliferation
O	0042100	biological_process	B cell proliferation
O	0042802	molecular_function	identical protein binding
O	0044210	biological_process	'de novo' CTP biosynthetic process
O	0097268	cellular_component	cytoophidium
P	0002376	biological_process	immune system process
P	0003883	molecular_function	CTP synthase activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006139	biological_process	nucleobase-containing compound metabolic process
P	0006221	biological_process	pyrimidine nucleotide biosynthetic process
P	0006241	biological_process	CTP biosynthetic process
P	0006541	biological_process	glutamine metabolic process
P	0009410	biological_process	response to xenobiotic stimulus
P	0016020	cellular_component	membrane
P	0016874	molecular_function	ligase activity
P	0019637	biological_process	organophosphate metabolic process
P	0019856	biological_process	pyrimidine nucleobase biosynthetic process
P	0042098	biological_process	T cell proliferation
P	0042100	biological_process	B cell proliferation
P	0042802	molecular_function	identical protein binding
P	0044210	biological_process	'de novo' CTP biosynthetic process
P	0097268	cellular_component	cytoophidium
Q	0002376	biological_process	immune system process
Q	0003883	molecular_function	CTP synthase activity
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006139	biological_process	nucleobase-containing compound metabolic process
Q	0006221	biological_process	pyrimidine nucleotide biosynthetic process
Q	0006241	biological_process	CTP biosynthetic process
Q	0006541	biological_process	glutamine metabolic process
Q	0009410	biological_process	response to xenobiotic stimulus
Q	0016020	cellular_component	membrane
Q	0016874	molecular_function	ligase activity
Q	0019637	biological_process	organophosphate metabolic process
Q	0019856	biological_process	pyrimidine nucleobase biosynthetic process
Q	0042098	biological_process	T cell proliferation
Q	0042100	biological_process	B cell proliferation
Q	0042802	molecular_function	identical protein binding
Q	0044210	biological_process	'de novo' CTP biosynthetic process
Q	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For GATase activity => ECO:0000250

Chain	Residue	Details
F	CYS399
Q	CYS399
Q	HIS526
Q	GLU528
F	HIS526
F	GLU528
O	CYS399
O	HIS526
O	GLU528
P	CYS399
P	HIS526
P	GLU528

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
F	LYS100
O	LYS100
P	LYS100
Q	LYS100

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21406692

Chain	Residue	Details
F	SER562
O	SER562
P	SER562
Q	SER562

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
F	SER568
F	SER587
O	SER568
O	SER587
P	SER568
P	SER587
Q	SER568
Q	SER587

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332

Chain	Residue	Details
F	SER571
O	SER571
P	SER571
Q	SER571

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:21406692

Chain	Residue	Details
F	SER573
O	SER573
P	SER573
Q	SER573

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
F	SER574
O	SER574
P	SER574
Q	SER574

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
F	SER575
O	SER575
P	SER575
Q	SER575

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P70698

Chain	Residue	Details
F	SER578
O	SER578
P	SER578
Q	SER578

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)