7MGZ

Human CTPS1 bound to UTP, AMPPNP, and glutamine

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000166	molecular_function	nucleotide binding
F	0000785	cellular_component	chromatin
F	0002376	biological_process	immune system process
F	0003883	molecular_function	CTP synthase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0006325	biological_process	chromatin organization
F	0006974	biological_process	DNA damage response
F	0009410	biological_process	response to xenobiotic stimulus
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0032480	biological_process	negative regulation of type I interferon production
F	0042098	biological_process	T cell proliferation
F	0042100	biological_process	B cell proliferation
F	0042802	molecular_function	identical protein binding
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0044281	biological_process	small molecule metabolic process
F	0097268	cellular_component	cytoophidium
F	0140861	biological_process	DNA repair-dependent chromatin remodeling
F	0160260	molecular_function	protein asparagine deamidase activity
F	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
F	1902340	biological_process	negative regulation of chromosome condensation
O	0000166	molecular_function	nucleotide binding
O	0000785	cellular_component	chromatin
O	0002376	biological_process	immune system process
O	0003883	molecular_function	CTP synthase activity
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005634	cellular_component	nucleus
O	0005694	cellular_component	chromosome
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006139	biological_process	nucleobase-containing compound metabolic process
O	0006221	biological_process	pyrimidine nucleotide biosynthetic process
O	0006241	biological_process	CTP biosynthetic process
O	0006325	biological_process	chromatin organization
O	0006974	biological_process	DNA damage response
O	0009410	biological_process	response to xenobiotic stimulus
O	0016020	cellular_component	membrane
O	0016787	molecular_function	hydrolase activity
O	0016874	molecular_function	ligase activity
O	0019856	biological_process	pyrimidine nucleobase biosynthetic process
O	0032480	biological_process	negative regulation of type I interferon production
O	0042098	biological_process	T cell proliferation
O	0042100	biological_process	B cell proliferation
O	0042802	molecular_function	identical protein binding
O	0044210	biological_process	'de novo' CTP biosynthetic process
O	0044281	biological_process	small molecule metabolic process
O	0097268	cellular_component	cytoophidium
O	0140861	biological_process	DNA repair-dependent chromatin remodeling
O	0160260	molecular_function	protein asparagine deamidase activity
O	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
O	1902340	biological_process	negative regulation of chromosome condensation
P	0000166	molecular_function	nucleotide binding
P	0000785	cellular_component	chromatin
P	0002376	biological_process	immune system process
P	0003883	molecular_function	CTP synthase activity
P	0005515	molecular_function	protein binding
P	0005524	molecular_function	ATP binding
P	0005634	cellular_component	nucleus
P	0005694	cellular_component	chromosome
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006139	biological_process	nucleobase-containing compound metabolic process
P	0006221	biological_process	pyrimidine nucleotide biosynthetic process
P	0006241	biological_process	CTP biosynthetic process
P	0006325	biological_process	chromatin organization
P	0006974	biological_process	DNA damage response
P	0009410	biological_process	response to xenobiotic stimulus
P	0016020	cellular_component	membrane
P	0016787	molecular_function	hydrolase activity
P	0016874	molecular_function	ligase activity
P	0019856	biological_process	pyrimidine nucleobase biosynthetic process
P	0032480	biological_process	negative regulation of type I interferon production
P	0042098	biological_process	T cell proliferation
P	0042100	biological_process	B cell proliferation
P	0042802	molecular_function	identical protein binding
P	0044210	biological_process	'de novo' CTP biosynthetic process
P	0044281	biological_process	small molecule metabolic process
P	0097268	cellular_component	cytoophidium
P	0140861	biological_process	DNA repair-dependent chromatin remodeling
P	0160260	molecular_function	protein asparagine deamidase activity
P	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
P	1902340	biological_process	negative regulation of chromosome condensation
Q	0000166	molecular_function	nucleotide binding
Q	0000785	cellular_component	chromatin
Q	0002376	biological_process	immune system process
Q	0003883	molecular_function	CTP synthase activity
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005694	cellular_component	chromosome
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006139	biological_process	nucleobase-containing compound metabolic process
Q	0006221	biological_process	pyrimidine nucleotide biosynthetic process
Q	0006241	biological_process	CTP biosynthetic process
Q	0006325	biological_process	chromatin organization
Q	0006974	biological_process	DNA damage response
Q	0009410	biological_process	response to xenobiotic stimulus
Q	0016020	cellular_component	membrane
Q	0016787	molecular_function	hydrolase activity
Q	0016874	molecular_function	ligase activity
Q	0019856	biological_process	pyrimidine nucleobase biosynthetic process
Q	0032480	biological_process	negative regulation of type I interferon production
Q	0042098	biological_process	T cell proliferation
Q	0042100	biological_process	B cell proliferation
Q	0042802	molecular_function	identical protein binding
Q	0044210	biological_process	'de novo' CTP biosynthetic process
Q	0044281	biological_process	small molecule metabolic process
Q	0097268	cellular_component	cytoophidium
Q	0140861	biological_process	DNA repair-dependent chromatin remodeling
Q	0160260	molecular_function	protein asparagine deamidase activity
Q	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
Q	1902340	biological_process	negative regulation of chromosome condensation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"For GATase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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