4V2P
 
 | | Ketosynthase MxnB | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, KETOSYNTHASE, ... | | 著者 | Koehnke, J. | | 登録日 | 2014-10-13 | | 公開日 | 2015-08-26 | | 最終更新日 | 2018-04-18 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | In vitro reconstitution of alpha-pyrone ring formation in myxopyronin biosynthesis.
Chem Sci, 6, 2015
|
|
6I5S
 | | AH, Bottromycin amidohydrolase | | 分子名称: | CHLORIDE ION, GLYCEROL, ZINC ION, ... | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2018-11-14 | | 公開日 | 2019-09-25 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Thiazoline-Specific Amidohydrolase PurAH Is the Gatekeeper of Bottromycin Biosynthesis.
J.Am.Chem.Soc., 141, 2019
|
|
7OC7
 | | LasB, alpha-alkyl-N-aryl mercaptoacetamide | | 分子名称: | (2R)-N,3-diphenyl-2-sulfanyl-propanamide, CALCIUM ION, Neutral metalloproteinase, ... | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2021-04-26 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
5LHK
 | |
5LHJ
 | | Bottromycin maturation enzyme BotP | | 分子名称: | CHLORIDE ION, GLYCEROL, Leucine aminopeptidase 2, ... | | 著者 | Koehnke, J, Mann, G. | | 登録日 | 2016-07-12 | | 公開日 | 2016-10-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP.
Chembiochem, 17, 2016
|
|
4V1U
 | |
4V1T
 | |
4V1V
 | |
6F8B
 | | LasB bound to thiol based inhibitor | | 分子名称: | CALCIUM ION, Elastase, ZINC ION, ... | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2017-12-12 | | 公開日 | 2018-03-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.
ACS Infect Dis, 4, 2018
|
|
8OO2
 | | ChdA complex with amido-chelocardin | | 分子名称: | 2-carboxamido-2-deacetyl-chelocardin, MAGNESIUM ION, Putative transcriptional regulator | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2023-04-04 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Revision of the Absolute Configurations of Chelocardin and Amidochelocardin.
Angew.Chem.Int.Ed.Engl., 62, 2023
|
|
7NLK
 | |
6T6H
 | |
6T6Z
 | |
6T6Y
 | |
6T70
 | |
6T6X
 | | Structure of the Bottromycin epimerase BotH in complex with substrate | | 分子名称: | (4~{R})-2-[(1~{R})-1-[[(2~{S})-2-[[(2~{S})-3-methyl-2-[[(4~{Z},6~{S},9~{S},12~{S})-2,8,11-tris(oxidanylidene)-6,9-di(propan-2-yl)-1,4,7,10-tetrazabicyclo[10.3.0]pentadec-4-en-5-yl]amino]butanoyl]amino]-3-phenyl-propanoyl]amino]-3-oxidanyl-3-oxidanylidene-propyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid, BotH | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2019-10-20 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | The bottromycin epimerase BotH defines a group of atypical alpha / beta-hydrolase-fold enzymes.
Nat.Chem.Biol., 16, 2020
|
|
6TH7
 | |
6FZX
 | | LasB, hydroxymate Inhibitor Complex | | 分子名称: | CALCIUM ION, GLYCEROL, Keratinase KP2, ... | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2018-03-15 | | 公開日 | 2018-09-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor.
ACS Chem. Biol., 13, 2018
|
|
5O2A
 | | FolD Q98H | | 分子名称: | Bifunctional protein FolD | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2017-05-19 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.
Nat Commun, 8, 2017
|
|
6YGQ
 | |
5O22
 | |
6H96
 | | AlbA-albicidin complex, albicidin resistance protein | | 分子名称: | 4-[[4-[[4-[(3~{S})-5-azanyl-3-[[4-[[(~{E})-3-(4-hydroxyphenyl)-2-methyl-prop-2-enoyl]amino]phenyl]carbonylamino]-2-oxidanylidene-3~{H}-pyrrol-1-yl]phenyl]carbonylamino]-3-methoxy-2-oxidanyl-phenyl]carbonylamino]-3-methoxy-2-oxidanyl-benzoic acid, Albicidin resistance protein, SULFATE ION | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2018-08-03 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA.
J.Am.Chem.Soc., 140, 2018
|
|
6H95
 | | AlbA, albicidin resistance protein | | 分子名称: | Albicidin resistance protein | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2018-08-03 | | 公開日 | 2018-11-21 | | 最終更新日 | 2019-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA.
J.Am.Chem.Soc., 140, 2018
|
|
6HAI
 | | AlbAM131A mutant in complex with albicidin , albicidin resistance protein | | 分子名称: | 4-[[4-[[4-[(3~{S})-3-[[4-[[(~{E})-3-(4-hydroxyphenyl)-2-methyl-prop-2-enoyl]amino]phenyl]carbonylamino]-2,5-bis(oxidanylidene)pyrrolidin-1-yl]phenyl]carbonylamino]-3-methoxy-2-oxidanyl-phenyl]carbonylamino]-3-methoxy-2-oxidanyl-benzoic acid, Albicidin resistance protein, SULFATE ION | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2018-08-07 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Adaptation of a Bacterial Multidrug Resistance System Revealed by the Structure and Function of AlbA.
J.Am.Chem.Soc., 140, 2018
|
|
5O28
 | | E. coli FolD apo | | 分子名称: | Bifunctional protein FolD | | 著者 | Koehnke, J, Sikandar, A. | | 登録日 | 2017-05-19 | | 公開日 | 2018-02-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.
Nat Commun, 8, 2017
|
|
