6IWB
 
 | | Crystal structure of a computationally designed protein (LD3) in complex with BCL-2 | | Descriptor: | Apolipoprotein E, Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2, SULFATE ION | | Authors: | Kim, S, Kwak, M.J, Oh, B.-H, Correia, B.E, Gainza, P. | | Deposit date: | 2018-12-05 | | Release date: | 2019-12-11 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy.
Nat.Biotechnol., 38, 2020
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6IEY
 | | Crystal structure of Chloramphenicol-Metabolizaing Enzyme EstDL136-Chloramphenicol complex | | Descriptor: | CHLORAMPHENICOL, Esterase | | Authors: | Kim, S.H, Kang, P.A, Han, K.T, Lee, S.W, Rhee, S.K. | | Deposit date: | 2018-09-18 | | Release date: | 2019-02-06 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome.
PLoS ONE, 14, 2019
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1SJ0
 | | Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D | | Descriptor: | (2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL, Estrogen receptor | | Authors: | Kim, S, Wu, J.Y, Birzin, E.T, Chan, W, Pai, L.Y, Yang, Y.T, Mosley, R.T, Fitzgerald, P.M, Sharma, N, DiNinno, F, Rohrer, S.P, Schaeffer, J.M, Hammond, M.L. | | Deposit date: | 2004-03-02 | | Release date: | 2004-04-27 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators.
J.Med.Chem., 47, 2004
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7KS6
 | | STRUCTURE OF TETRASACCHARIDE BUILDING BLOCK OF A SULFATED FUCAN FROM LYTECHINUS VARIEGATUS | | Descriptor: | 4-O-sulfo-alpha-L-fucopyranose-(1-3)-2,4-di-O-sulfo-alpha-L-fucopyranose-(1-3)-2-O-sulfo-alpha-L-fucopyranose-(1-3)-2-O-sulfo-alpha-L-fucopyranose | | Authors: | Kim, S.B, Thara, R, Aderibigbe, A.O, Doerksen, R.J, Pomin, V.H. | | Deposit date: | 2020-11-21 | | Release date: | 2020-12-16 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Conformational properties of l-fucose and the tetrasaccharide building block of the sulfated l-fucan from Lytechinus variegatus.
J.Struct.Biol., 209, 2020
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6AA7
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6AAE
 | | Crystal structure of Chloramphenicol-Metabolizaing Enzyme EstDL136 | | Descriptor: | DI(HYDROXYETHYL)ETHER, Esterase, PENTAETHYLENE GLYCOL | | Authors: | Kim, S.H, Kang, P.A, Han, K.T, Lee, S.W, Rhee, S.K. | | Deposit date: | 2018-07-18 | | Release date: | 2019-02-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.641 Å) | | Cite: | Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome.
PLoS ONE, 14, 2019
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8F8E
 | | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-8268 compound | | Descriptor: | (3P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-3-(4-chloro-2-fluorophenyl)-1H-pyrazole-4-carboxamide, CITRIC ACID, DDB1- and CUL4-associated factor 1 | | Authors: | Kimani, S, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2022-11-21 | | Release date: | 2023-03-01 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-8268 compound
To be published
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9BKS
 | | Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Isoform 2 of E3 ubiquitin-protein ligase TRIP12 | | Authors: | Kimani, S, Dong, A, Li, Y, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-04-29 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (1.17 Å) | | Cite: | Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ADP
To be published
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9BKR
 | | Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Isoform 2 of E3 ubiquitin-protein ligase TRIP12, UNKNOWN ATOM OR ION | | Authors: | Kimani, S, Dong, A, Li, Y, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-04-29 | | Release date: | 2024-07-31 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structure of the Human TRIP12 WWE domain (isoform 2) in complex with ATP
To be published
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8GCY
 | | Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one, E3 ubiquitin-protein ligase CBL-B, ... | | Authors: | Kimani, S, Zeng, H, Dong, A, Li, Y, Santhakumar, V, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2023-03-03 | | Release date: | 2023-03-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition.
Commun Biol, 6, 2023
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5AXM
 | | Crystal structure of Thg1 like protein (TLP) with tRNA(Phe) | | Descriptor: | MAGNESIUM ION, RNA (75-MER), tRNA(His)-5'-guanylyltransferase (Thg1) like protein | | Authors: | Kimura, S, Suzuki, T, Yu, J, Kato, K, Yao, M. | | Deposit date: | 2015-07-31 | | Release date: | 2016-08-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein
Sci Adv, 2, 2016
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5AXN
 | | Crystal structure of Thg1 like protein (TLP) with tRNA(Phe) and GDPNP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RNA (75-MER), ... | | Authors: | Kimura, S, Suzuki, T, Yu, J, Kato, K, Yao, M. | | Deposit date: | 2015-07-31 | | Release date: | 2016-08-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.703 Å) | | Cite: | Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein
Sci Adv, 2, 2016
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5AXL
 | | Crystal structure of Thg1 like protein (TLP) with GTP | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, tRNA(His)-5'-guanylyltransferase (Thg1) like protein | | Authors: | Kimura, S, Suzuki, T, Yu, J, Kato, K, Yao, M. | | Deposit date: | 2015-07-31 | | Release date: | 2016-08-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.998 Å) | | Cite: | Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein
Sci Adv, 2, 2016
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5AXK
 | | Crystal structure of Thg1 like protein (TLP) | | Descriptor: | GLYCEROL, tRNA(His)-5'-guanylyltransferase (Thg1) like protein | | Authors: | Kimura, S, Suzuki, T, Yu, J, Kato, K, Yao, M. | | Deposit date: | 2015-07-31 | | Release date: | 2016-08-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein
Sci Adv, 2, 2016
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4IZT
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4IZU
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4IZV
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4IZW
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4IZS
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7SSE
 | | Crystal structure of the WDR domain of human DCAF1 in complex with CYCA-117-70 | | Descriptor: | DDB1- and CUL4-associated factor 1, N-[(3R)-1-(3-fluorophenyl)piperidin-3-yl]-6-(morpholin-4-yl)pyrimidin-4-amine | | Authors: | Kimani, S, Owen, J, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Shahani, V.M, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2021-11-10 | | Release date: | 2021-12-15 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Discovery of a Novel DCAF1 Ligand Using a Drug-Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets.
J.Chem.Inf.Model., 63, 2023
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5NXZ
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5NYE
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5NYB
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5NY2
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5NZ5
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