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4IZT

The E41Q mutant of the amidase from Nesterenkonia sp. AN1 showing covalent addition of the acetamide moiety of fluoroacetamide at the active site cysteine

Summary for 4IZT
Entry DOI10.2210/pdb4izt/pdb
Related3HKX 4IZS 4IZU 4IZV 4IZW
DescriptorAmidase, ACETAMIDE, 2-fluoroacetamide, ... (4 entities in total)
Functional Keywordsfluoroacetamide, acetamide, hydrolase-substrate complex, hydrolase/substrate
Biological sourceNesterenkonia sp. 10004
Total number of polymer chains1
Total formula weight30312.95
Authors
Kimani, S.W.,Sewell, B.T. (deposition date: 2013-01-30, release date: 2014-02-12)
Primary citationKimani, S.W.,Hunter, R.,Vlok, M.,Watermeyer, J.,Sewell, B.T.
Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published,
Experimental method
X-RAY DIFFRACTION (1.92 Å)
Structure validation

221716

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