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PDB: 55 件
7S3B
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BU of 7s3b by Molmil
Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide
分子名称: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*GP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
著者Jenkins, J.L, Henderson, S, Kielkopf, C.L.
登録日2021-09-05
公開日2022-05-25
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.
Nucleic Acids Res., 50, 2022
7S3C
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BU of 7s3c by Molmil
Crystal structure of intact U2AF65 RRM-region bound to AdML-A5 oligonucleotide
分子名称: DNA/RNA (5'-R(P*UP*UP*(UD)P*AP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit
著者Glasser, E, Jenkins, J.L, Kielkopf, C.L.
登録日2021-09-05
公開日2022-05-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.
Nucleic Acids Res., 50, 2022
5EV1
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BU of 5ev1 by Molmil
Structure I of Intact U2AF65 Recognizing a 3' Splice Site Signal
分子名称: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(*UP*UP*U)-D(P*UP*UP*(BRU)P*U)-R(P*UP*U)-3'), SODIUM ION, ...
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.037 Å)
主引用文献An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV2
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Structure II of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称: 1,4-DIETHYLENE DIOXIDE, DI(HYDROXYETHYL)ETHER, DNA (5'-R(P*UP*U)-D(P*UP*U)-R(P*U)-D(P*UP*(BRU)P*U)-3'), ...
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV3
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Structure III of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*U)-3'), Splicing factor U2AF 65 kDa subunit
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
5EV4
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Structure IV of Intact U2AF65 Recognizing the 3' Splice Site Signal
分子名称: DNA/RNA (5'-R(P*UP*UP*UP*(UD)P*UP*U)-D(P*(BRU)P*(UD))-R(P*C)-3'), GLYCEROL, Splicing factor U2AF 65 kDa subunit
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2015-11-19
公開日2016-02-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.
Nat Commun, 7, 2016
6N3D
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Structure of HIV Tat-specific factor 1 U2AF Homology Motif (APO-State)
分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Loerch, S, Jenkins, J.L, Kielkopf, C.L.
登録日2018-11-15
公開日2019-01-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.13 Å)
主引用文献The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6N3F
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Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, HIV Tat-specific factor 1, ...
著者Leach, J.R, Jenkins, J.L, Kielkopf, C.L.
登録日2018-11-15
公開日2019-01-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6N3E
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BU of 6n3e by Molmil
Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to U2AF ligand motif 4
分子名称: FORMIC ACID, GLYCEROL, HIV Tat-specific factor 1, ...
著者Loerch, S, Jenkins, J.L, Kielkopf, C.L.
登録日2018-11-15
公開日2019-01-02
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.893 Å)
主引用文献The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface.
J. Biol. Chem., 294, 2019
6NSX
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BU of 6nsx by Molmil
Yeast Hsh155 Ligand bound to Human Tat-SF1 Motif
分子名称: CHLORIDE ION, HIV Tat-specific factor 1, Hsh155
著者Jenkins, J.L, Leach, J.R, Kielkopf, C.L.
登録日2019-01-25
公開日2019-06-05
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction.
Rna, 25, 2019
4OZ1
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BU of 4oz1 by Molmil
Crystal structure of human CAPERalpha UHM bound to SF3b155 ULM5
分子名称: CHLORIDE ION, LYSINE, POTASSIUM ION, ...
著者Loerch, S, Kielkopf, C.L.
登録日2014-02-13
公開日2014-05-14
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Cancer-relevant splicing factor CAPER alpha engages the essential splicing factor SF3b155 in a specific ternary complex.
J.Biol.Chem., 289, 2014
3CGP
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BU of 3cgp by Molmil
X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex bound to iodide ions
分子名称: IODIDE ION, RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), ...
著者Lin, Y, Kielkopf, C.L.
登録日2008-03-06
公開日2008-07-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGS
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BU of 3cgs by Molmil
X-ray structure containing the pseudouridylated U2 snRNA and mammalian intron branch site consensus sequences
分子名称: MAGNESIUM ION, RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*GP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3')
著者Lin, Y, Kielkopf, C.L.
登録日2008-03-06
公開日2008-07-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGR
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BU of 3cgr by Molmil
X-ray structure containing the pseudouridylated U2 snRNA and intron branch site consensus sequences
分子名称: RNA (5'-R(*CP*GP*CP*AP*CP*UP*AP*AP*CP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*GP*(PSU)P*AP*GP*UP*GP*C)-3'), SULFATE ION
著者Lin, Y, Kielkopf, C.L.
登録日2008-03-06
公開日2008-07-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
3CGQ
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BU of 3cgq by Molmil
X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex
分子名称: RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3'), SULFATE ION
著者Lin, Y, Kielkopf, C.L.
登録日2008-03-06
公開日2008-07-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines.
Biochemistry, 47, 2008
4TU9
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BU of 4tu9 by Molmil
STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DG*U)-3'), GLYCEROL, ...
著者Jenkins, J.L, McLaughlin, K.J, Agrawal, A.A, Kielkopf, C.L.
登録日2014-06-24
公開日2014-11-26
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.992 Å)
主引用文献Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TU8
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STRUCTURE OF U2AF65 VARIANT WITH BRU5A6 DNA
分子名称: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*DA*U)-3'), ...
著者MCLAUGHLIN, K.J, JENKINS, J.L, Agrawal, A.A, KIELKOPF, C.L.
登録日2014-06-24
公開日2014-11-26
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.918 Å)
主引用文献Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TU7
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Structure of U2AF65 D231V variant with BrU5 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*UP*UP*UP*UP*(BRU)P*UP*U)-3'), GLYCEROL, ...
著者Agrawal, A.A, Jenkins, J.L, Kielkopf, C.L.
登録日2014-06-24
公開日2014-11-26
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.087 Å)
主引用文献Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA.
Proc.Natl.Acad.Sci.USA, 111, 2014
1M6S
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BU of 1m6s by Molmil
Crystal Structure Of Threonine Aldolase
分子名称: CALCIUM ION, CHLORIDE ION, L-allo-threonine aldolase
著者Burley, S.K, Kielkopf, C.L.
登録日2002-07-17
公開日2002-12-11
最終更新日2021-02-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献X-ray Structures of Threonine Aldolase Complexes: Structural Basis of Substrate Recognition
Biochemistry, 41, 2002
3IL2
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BU of 3il2 by Molmil
Crystal structure of a Rex-family repressor R90D mutant/DNA complex from Thermus aquaticus
分子名称: Redox-sensing transcriptional repressor rex, Rex operator DNA
著者McLaughlin, K.J, Kielkopf, C.L.
登録日2009-08-06
公開日2010-06-09
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.
Mol.Cell, 38, 2010
3IKV
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BU of 3ikv by Molmil
Crystal structure of a Rex-family repressor R90D mutant from Thermus aquaticus
分子名称: CALCIUM ION, Redox-sensing transcriptional repressor rex
著者McLaughlin, K.J, Kielkopf, C.L.
登録日2009-08-06
公開日2010-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.
Mol.Cell, 38, 2010
3IKT
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BU of 3ikt by Molmil
Crystal structure of a Rex-family repressor/DNA/NAD+ complex from Thermus aquaticus
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Redox-sensing transcriptional repressor rex, Rex operator DNA
著者McLaughlin, K.J, Kielkopf, C.L.
登録日2009-08-06
公開日2010-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Structural basis for NADH/NAD+ redox sensing by a Rex family repressor.
Mol.Cell, 38, 2010
3VAG
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BU of 3vag by Molmil
Structure of U2AF65 variant with BrU3C2 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(*U*CP*(BRU)P*UP*UP*UP*U)-3', GLYCEROL, ...
著者Jenkins, J.L, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAH
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Structure of U2AF65 variant with BrU3C4 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA 5'-D(P*UP*UP*(BRU)P*CP*UP*UP*U)-3', GLYCEROL, ...
著者Jenkins, J.L, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013
3VAL
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BU of 3val by Molmil
Structure of U2AF65 variant with BrU5C1 DNA
分子名称: 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*C*UP*UP*UP*(BRU)P*UP*U)-3'), SULFATE ION, ...
著者Jenkins, J.L, Frato, K.H, Kielkopf, C.L.
登録日2011-12-29
公開日2013-02-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.
Nucleic Acids Res., 41, 2013

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件を2024-09-04に公開中

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