8VC8
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8V2F
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![BU of 8v2f by Molmil](/molmil-images/mine/8v2f) | Crystal structure of IRAK4 kinase domain with compound 9 | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-22 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
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8V1O
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![BU of 8v1o by Molmil](/molmil-images/mine/8v1o) | Crystal structure of IRAK4 kinase domain with compound 4 | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-21 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
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8V2L
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![BU of 8v2l by Molmil](/molmil-images/mine/8v2l) | Crystal structure of IRAK4 kinase domain with compound 8 | 分子名称: | 1,2-ETHANEDIOL, Interleukin-1 receptor-associated kinase 4, N-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-22 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
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6WVS
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![BU of 6wvs by Molmil](/molmil-images/mine/6wvs) | Hyperstable de novo TIM barrel variant DeNovoTIM15 | 分子名称: | DeNovoTIM15 hyperstable de novo TIM barrel | 著者 | Bick, M.J, Haydon, I.C, Caldwell, S.J, Zeymer, C, Huang, P, Fernandez-Velasco, D.A, Baker, D. | 登録日 | 2020-05-06 | 公開日 | 2020-11-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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8UTK
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![BU of 8utk by Molmil](/molmil-images/mine/8utk) | IL-23R minibinder - 23R-B04dslf02IB | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 23R-B04dslf02IB, ... | 著者 | Bera, A.K, Berger, S.A, Kang, A, Baker, D. | 登録日 | 2023-10-31 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Preclinical proof of principle for orally delivered Th17 antagonist miniproteins. Cell, 2024
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8E55
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8E1E
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8F54
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8F4X
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8F53
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8CYK
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![BU of 8cyk by Molmil](/molmil-images/mine/8cyk) | Crystal structure of hallucinated protein HALC1_878 | 分子名称: | HALC1_878 | 著者 | Ragotte, R.J, Bera, A.K, Milles, L.F, Wicky, B.I.M, Baker, D. | 登録日 | 2022-05-23 | 公開日 | 2022-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Robust deep learning-based protein sequence design using ProteinMPNN. Science, 378, 2022
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6TMS
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![BU of 6tms by Molmil](/molmil-images/mine/6tms) | Crystal structure of a de novo designed hexameric helical-bundle protein | 分子名称: | SULFATE ION, a novel designed pore protein, affinity purification tag | 著者 | Xu, C, Pei, X.Y, Luisi, B.F, Baker, D. | 登録日 | 2019-12-05 | 公開日 | 2020-04-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Computational design of transmembrane pores. Nature, 585, 2020
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6Q4Q
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![BU of 6q4q by Molmil](/molmil-images/mine/6q4q) | The Crystal structure of CK2a bound to P2-C4 | 分子名称: | 3,5-bis(1-methyl-1,2,3-triazol-4-yl)benzoic acid, ACETATE ION, BENZOIC ACID, ... | 著者 | Brear, P, Iegre, J, Baker, D, Tan, Y, Sore, H, Donovan, D, Spring, D, Chandra, V, Hyvonen, M. | 登録日 | 2018-12-06 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction. Chem Sci, 10, 2019
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6Q38
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![BU of 6q38 by Molmil](/molmil-images/mine/6q38) | The Crystal structure of CK2a bound to P1-C4 | 分子名称: | 3,5-bis(1-methyl-1,2,3-triazol-4-yl)benzoic acid, BENZOIC ACID, Casein kinase II subunit alpha, ... | 著者 | Brear, P, Iegre, J, Baker, D, Tan, Y, Sore, H, Donovan, D, Spring, D, Chandra, V, Hyvonen, M. | 登録日 | 2018-12-03 | 公開日 | 2019-04-24 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction. Chem Sci, 10, 2019
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6DMA
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![BU of 6dma by Molmil](/molmil-images/mine/6dma) | DHD15_closed | 分子名称: | DHD15_closed_A, DHD15_closed_B | 著者 | Bick, M.J, Chen, Z, Baker, D. | 登録日 | 2018-06-04 | 公開日 | 2018-12-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.363 Å) | 主引用文献 | Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
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6U1S
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![BU of 6u1s by Molmil](/molmil-images/mine/6u1s) | Cryo-EM structure of a de novo designed 16-helix transmembrane nanopore, TMHC8_R. | 分子名称: | de novo designed 16-helix transmembrane nanopore, TMHC8_R | 著者 | Johnson, M.J, Reggiano, G, Xu, C, Lu, P, Hsia, Y, Brunette, T.J, DiMaio, F, Baker, D, Kollman, J. | 登録日 | 2019-08-16 | 公開日 | 2020-08-19 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | 主引用文献 | Computational Design of Transmembrane Channels To Be Published
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6DKM
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![BU of 6dkm by Molmil](/molmil-images/mine/6dkm) | DHD131 | 分子名称: | DHD131_A, DHD131_B | 著者 | Bick, M.J, Chen, Z, Baker, D. | 登録日 | 2018-05-29 | 公開日 | 2018-12-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
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6DM9
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![BU of 6dm9 by Molmil](/molmil-images/mine/6dm9) | DHD15_extended | 分子名称: | DHD15_extended_A, DHD15_extended_B, SULFATE ION | 著者 | Bick, M.J, Chen, Z, Baker, D. | 登録日 | 2018-06-04 | 公開日 | 2018-12-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
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6ZV9
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![BU of 6zv9 by Molmil](/molmil-images/mine/6zv9) | Terbium(III)-bound de novo TIM barrel-ferredoxin fold fusion dimer with 4-glutamate binding site and tryptophan antenna (TFD-EE N6W) | 分子名称: | 1,2-ETHANEDIOL, TERBIUM(III) ION, TFD-EE | 著者 | Caldwell, S, Haydon, I, Piperidou, N, Huang, P, Hilvert, D, Baker, D, Zeymer, C. | 登録日 | 2020-07-24 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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6TJ1
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![BU of 6tj1 by Molmil](/molmil-images/mine/6tj1) | Crystal structure of a de novo designed hexameric helical-bundle protein | 分子名称: | De novo designed WSHC6, purification tag | 著者 | Xu, C, Pei, X.Y, Luisi, B.F, Baker, D. | 登録日 | 2019-11-23 | 公開日 | 2020-04-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Computational design of transmembrane pores. Nature, 585, 2020
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6DLC
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6DLM
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![BU of 6dlm by Molmil](/molmil-images/mine/6dlm) | DHD127 | 分子名称: | DHD127_A, DHD127_B | 著者 | Bick, M.J, Chen, Z, Baker, D. | 登録日 | 2018-06-01 | 公開日 | 2018-12-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.753 Å) | 主引用文献 | Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
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6VEH
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7UWY
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![BU of 7uwy by Molmil](/molmil-images/mine/7uwy) | NMR solution structure of the De novo designed small beta-barrel protein 29_bp_sh3 | 分子名称: | De novo designed small beta-barrel protein 29_bp_sh3 | 著者 | Peterson, F.C, Kim, D.E, Jensen, D.R, Saleem, A, Chow, C.M, Volkman, B.F, Baker, D. | 登録日 | 2022-05-04 | 公開日 | 2023-03-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design of small beta barrel proteins. Proc.Natl.Acad.Sci.USA, 120, 2023
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