7MI9
| Full integration complex of Cas1/Cas2 from Cas4-containing system | 分子名称: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (5'-D(P*CP*GP*GP*AP*AP*AP*AP*GP*AP*GP*CP*C)-3'), ... | 著者 | Hu, C.Y, Ke, A.K. | 登録日 | 2021-04-16 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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7MID
| Sub-complex of Cas4-Cas1-Cas2 bound PAM containing DNA | 分子名称: | CRISPR-associated endoribonuclease Cas2, CRISPR-associated exonuclease Cas4/endonuclease Cas1 fusion, DNA (33-MER), ... | 著者 | Hu, C.Y, Ke, A.K. | 登録日 | 2021-04-16 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Mechanism for Cas4-assisted directional spacer acquisition in CRISPR-Cas. Nature, 598, 2021
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7MIB
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5U3G
| Structure of the Dickeya dadantii ykkC riboswitch bound to guanidinium | 分子名称: | GUANIDINE, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Battaglia, R.A, Price, I.R, Ke, A. | 登録日 | 2016-12-02 | 公開日 | 2017-02-01 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for guanidine sensing by the ykkC family of riboswitches. RNA, 23, 2017
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6C66
| CRISPR RNA-guided surveillance complex, pre-nicking | 分子名称: | CRISPR-associated helicase, Cas3 family, CRISPR-associated protein, ... | 著者 | Xiao, Y, Luo, M, Liao, M, Ke, A. | 登録日 | 2018-01-17 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Structure basis for RNA-guided DNA degradation by Cascade and Cas3. Science, 361, 2018
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4MGN
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4JRC
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4MGM
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7UTN
| IscB and wRNA bound to Target DNA | 分子名称: | DNA non-target strand, DNA target strand, IscB, ... | 著者 | Schuler, G.A, Hu, C, Ke, A. | 登録日 | 2022-04-27 | 公開日 | 2022-06-15 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Structural basis for RNA-guided DNA cleavage by IscB-omega RNA and mechanistic comparison with Cas9. Science, 376, 2022
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5U0A
| CRISPR RNA-guided surveillance complex | 分子名称: | CRISPR-associated protein, Cas5e family, Cse1 family, ... | 著者 | Xiao, Y, Luo, M, Hayes, R.P, Kim, J, Ng, S, Ding, F, Liao, M, Ke, A. | 登録日 | 2016-11-23 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System. Cell, 170, 2017
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5U07
| CRISPR RNA-guided surveillance complex | 分子名称: | CRISPR-associated protein, Cas5e family, Cse1 family, ... | 著者 | Xiao, Y, Luo, M, Hayes, R.P, Kim, J, Ng, S, Ding, F, Liao, M, Ke, A. | 登録日 | 2016-11-23 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System. Cell, 170, 2017
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8G9U
| Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | CRISPR-associated protein, Csd1 family, Csd2 family, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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5H9E
| Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution. | 分子名称: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | 著者 | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | 登録日 | 2015-12-28 | 公開日 | 2016-02-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
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5H9F
| Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom resolution. | 分子名称: | CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ... | 著者 | Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A. | 登録日 | 2015-12-28 | 公開日 | 2016-02-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature, 530, 2016
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8GAM
| Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | Cas11, Cas5, Cas7, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-23 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8GAN
| Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | Cas11, Cas5, Cas7, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-23 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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6N2V
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3L7Z
| Crystal structure of the S. solfataricus archaeal exosome | 分子名称: | Probable exosome complex RNA-binding protein 1, Probable exosome complex exonuclease 1, Probable exosome complex exonuclease 2, ... | 著者 | Lu, C, Ding, F, Ke, A. | 登録日 | 2009-12-29 | 公開日 | 2010-06-23 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring. Plos One, 5, 2010
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7UZ0
| AntiT-tRNA flip UCCA | 分子名称: | AntiT-tRNA flip UCCA, MAGNESIUM ION, STRONTIUM ION | 著者 | Price, I.R, Grigg, J.C, Ke, A. | 登録日 | 2022-05-07 | 公開日 | 2022-06-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | 主引用文献 | tRNA Fusion to Streamline RNA Structure Determination: Case Studies in Probing Aminoacyl-tRNA Sensing Mechanisms by the T-Box Riboswitch Crystals, 12, 2022
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8GAF
| Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | Cas11, Cas5, Cas7, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8G9S
| Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | AcrIC8, Cas11, Cas5, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8G9T
| Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | AcrIC9, Cas11, Cas5, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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6JXM
| Crystal Structure of phi29 pRNA domain II | 分子名称: | BARIUM ION, MAGNESIUM ION, RNA (97-mer) | 著者 | Cai, R, Price, I.R, Ding, F, Wu, F, Chen, T, Zhang, Y, Liu, G, Jardine, P.J, Lu, C, Ke, A. | 登録日 | 2019-04-24 | 公開日 | 2019-08-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | ATP/ADP modulates gp16-pRNA conformational change in the Phi29 DNA packaging motor. Nucleic Acids Res., 47, 2019
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5XVO
| E. fae Cas1-Cas2/prespacer/target ternary complex revealing DNA sampling and half-integration states | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | 著者 | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | 登録日 | 2017-06-28 | 公開日 | 2017-10-04 | 最終更新日 | 2022-10-12 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration. Nature, 550, 2017
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5XVN
| E. far Cas1-Cas2/prespacer binary complex | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | 著者 | Xiao, Y, Ng, S, Nam, K.H, Ke, A. | 登録日 | 2017-06-28 | 公開日 | 2017-10-04 | 最終更新日 | 2022-10-12 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration. Nature, 550, 2017
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