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PDB: 70 results

7LB4
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BU of 7lb4 by Molmil
Crystal structure of the second bromodomain (BD2) of human BRD3 bound to bromosporine
Descriptor: Bromodomain-containing protein 3, Bromosporine
Authors:Karim, M.R, Bikowitz, M.J, Schonbrunn, E.
Deposit date:2021-01-07
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7L9J
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BU of 7l9j by Molmil
Crystal structure of the second bromodomain (BD2) of human BRD2 bound to Ro3280
Descriptor: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 2, CHLORIDE ION
Authors:Karim, M.R, Bikowitz, M.J, Schonbrunn, E.
Deposit date:2021-01-04
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7LAZ
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BU of 7laz by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD3 bound to ERK5-IN-1
Descriptor: 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 3
Authors:Karim, M.R, Bikowitz, M.J, Schonbrunn, E.
Deposit date:2021-01-07
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7LBT
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BU of 7lbt by Molmil
Crystal structure of the second bromodomain (BD2) of human BRD3 bound to ERK5-IN-1
Descriptor: 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 3
Authors:Karim, M.R, Bikowitz, M.J, Schonbrunn, E.
Deposit date:2021-01-08
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7LAY
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BU of 7lay by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD3 bound to SG3-179
Descriptor: 1,2-ETHANEDIOL, 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 3, ...
Authors:Karim, M.R, Bikowitz, M.J, Schonbrunn, E.
Deposit date:2021-01-07
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7LAK
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BU of 7lak by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD2 bound to volasertib
Descriptor: Bromodomain-containing protein 2, N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide
Authors:Karim, M.R, Bikowitz, M, Chan, A, Schonbrunn, E.
Deposit date:2021-01-06
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.831 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7BJY
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BU of 7bjy by Molmil
Crystal structure of the first bromodomain (BD1) of human BRDT bound to Ro3280
Descriptor: 1,2-ETHANEDIOL, 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Isoform 2 of Bromodomain testis-specific protein
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2021-01-14
Release date:2021-08-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
6PPA
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BU of 6ppa by Molmil
Crystal structure of the unliganded bromodomain of human BRD7
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 7, PHOSPHATE ION
Authors:Chan, A, Karim, M.R, Zhu, J, Schonbrunn, E.
Deposit date:2019-07-05
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1K
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BU of 6v1k by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to BI7273
Descriptor: 1,2-ETHANEDIOL, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 4
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1E
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BU of 6v1e by Molmil
Crystal structure of the bromodomain of human BRD7 bound to BI7273
Descriptor: 1,2-ETHANEDIOL, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 7
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1H
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BU of 6v1h by Molmil
Crystal structure of the bromodomain of human BRD7 bound to bromosporine
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 7, Bromosporine
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1L
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BU of 6v1l by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to BI9564
Descriptor: 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 4
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1U
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BU of 6v1u by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to TP-472
Descriptor: 1,2-ETHANEDIOL, 3-(6-acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide, Bromodomain-containing protein 4
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-21
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V0U
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BU of 6v0u by Molmil
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to bromosporine
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, Bromosporine
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-19
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
6V1F
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BU of 6v1f by Molmil
Crystal structure of the bromodomain of human BRD7 bound to BI9564
Descriptor: 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, Bromodomain-containing protein 7
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2019-11-20
Release date:2020-03-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
J.Med.Chem., 63, 2020
7L73
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BU of 7l73 by Molmil
Crystal structure of the first bromodomain (BD1) of human BRDT bound to ERK5-IN-1
Descriptor: 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain testis-specific protein
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2020-12-25
Release date:2021-06-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7LEL
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BU of 7lel by Molmil
Crystal structure of the second bromodomain (BD2) of human BRDT bound to Bromosporine
Descriptor: Bromodomain testis-specific protein, Bromosporine
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2021-01-14
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7LEJ
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BU of 7lej by Molmil
Crystal structure of the second bromodomain (BD2) of human BRDT bound to Volasertib
Descriptor: Bromodomain testis-specific protein, N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2021-01-14
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7LEM
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BU of 7lem by Molmil
Crystal structure of the first bromodomain (BD1) of human BRDT bound to LRRK2-IN-1
Descriptor: 1,2-ETHANEDIOL, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain testis-specific protein
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2021-01-14
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
7LEK
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BU of 7lek by Molmil
Crystal structure of the second bromodomain (BD2) of human BRDT bound to ERK5-IN-1
Descriptor: 1,2-ETHANEDIOL, 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain testis-specific protein, ...
Authors:Chan, A, Karim, M.R, Schonbrunn, E.
Deposit date:2021-01-14
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
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數據於2024-09-18公開中

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