7L73

Crystal structure of the first bromodomain (BD1) of human BRDT bound to ERK5-IN-1

Summary for 7L73

Entry DOI	10.2210/pdb7l73/pdb
Descriptor	Bromodomain testis-specific protein, 11-cyclopentyl-2-({2-ethoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total)
Functional Keywords	brdt, bet, plk1, testis specific, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14596.97
Authors	Chan, A.,Karim, M.R.,Schonbrunn, E. (deposition date: 2020-12-25, release date: 2021-06-30, Last modification date: 2023-10-18)
Primary citation	Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64:15772-15786, 2021 Cited by PubMed: 34710325 DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation