6V1K
Crystal structure of the first bromodomain (BD1) of human BRD4 bound to BI7273
Summary for 6V1K
Entry DOI | 10.2210/pdb6v1k/pdb |
Descriptor | Bromodomain-containing protein 4, 4-[4-[(dimethylamino)methyl]-3,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromosporine, brd4, brd, bet, gene regulation, hunk1 |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15763.14 |
Authors | Chan, A.,Karim, M.R.,Schonbrunn, E. (deposition date: 2019-11-20, release date: 2020-03-11, Last modification date: 2023-10-11) |
Primary citation | Karim, R.M.,Chan, A.,Zhu, J.Y.,Schonbrunn, E. Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem., 63:3227-3237, 2020 Cited by PubMed: 32091206DOI: 10.1021/acs.jmedchem.9b01980 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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