7LB4

Crystal structure of the second bromodomain (BD2) of human BRD3 bound to bromosporine

Summary for 7LB4

Entry DOI	10.2210/pdb7lb4/pdb
Descriptor	Bromodomain-containing protein 3, Bromosporine (3 entities in total)
Functional Keywords	bet, erk5, dual brd-kinase inhibitor, gene regulation, gene regulation-inhibitor complex, gene regulation/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	27423.69
Authors	Karim, M.R.,Bikowitz, M.J.,Schonbrunn, E. (deposition date: 2021-01-07, release date: 2021-07-14, Last modification date: 2023-10-18)
Primary citation	Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64:15772-15786, 2021 Cited by PubMed: 34710325 DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.004 Å)

Structure validation