7LEM

Crystal structure of the first bromodomain (BD1) of human BRDT bound to LRRK2-IN-1

Summary for 7LEM

• Entry DOI: 10.2210/pdb7lem/pdb
• Descriptor: Bromodomain testis-specific protein, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, lrrk, kinase, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 28400.78

Authors

Chan, A.,Karim, M.R.,Schonbrunn, E. (deposition date: 2021-01-14, release date: 2021-07-14, Last modification date: 2023-10-18)

• Primary citation: Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E.; Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.; J.Med.Chem., 64:15772-15786, 2021; PubMed: 34710325; DOI: 10.1021/acs.jmedchem.1c01096

Experimental method

X-RAY DIFFRACTION (1.89 Å)