7LEM
Crystal structure of the first bromodomain (BD1) of human BRDT bound to LRRK2-IN-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain testis-specific protein | polymer | 113 | 13319.4 | 2 | UniProt (Q58F21) Pfam (PF00439) | Homo sapiens (Human) | Cancer/testis antigen 9,CT9,RING3-like protein |
| 2 | C, I (A, B) | 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | non-polymer | 570.7 | 2 | Chemie (4K4) | |||
| 3 | D, E, F, G, H... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 4 | O, P (A, B) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A, B: 29 - 137 (UniProt: Q58F21)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Ala 26 | - | expression tag |
| Ala 27 | - | expression tag |
| Ser 28 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26638.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1762.0 | |
| All* | Total formula weight | 28400.8 |
