7NLM
| LasB, N-aryl-2-butylmercaptoacetamide | 分子名称: | (S)-2-mercapto-N-(4-methoxyphenyl)-4-methylpentanamide, CALCIUM ION, Pro-elastase, ... | 著者 | Koehnke, J, Sikandar, A. | 登録日 | 2021-02-22 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | LasB, N-aryl-2-butylmercaptoacetamide inhibitor complex to be published
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5W3K
| Crystal structure of Staphylococcus aureus ketol-acid reductoisomerase in complex NADPH, Mg2+ and CPD | 分子名称: | Ketol-acid reductoisomerase (NADP(+)), MAGNESIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Patel, K.M, Teran, D, Zheng, S, Kandale, A, Schembri, M, McGeary, R.P, Schenk, G, Guddat, L.W. | 登録日 | 2017-06-08 | 公開日 | 2017-10-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.589 Å) | 主引用文献 | Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity. Chemistry, 23, 2017
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5OFI
| PllA lectin, Fluorophore carbohydrate complex | 分子名称: | 5-[2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxyethylcarbamothioylamino]-2-(6-oxidanyl-3-oxidanylidene-4,9-dihydroxanthen-9-yl)benzoic acid, CALCIUM ION, PIIA | 著者 | Koehnke, J, Sikandar, A. | 登録日 | 2017-07-11 | 公開日 | 2017-10-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Photorhabdus luminescens lectin A (PllA): A new probe for detecting alpha-galactoside-terminating glycoconjugates. J. Biol. Chem., 292, 2017
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5OFZ
| PllA lectin, apo | 分子名称: | Uncharacterized protein | 著者 | Koehnke, J, Sikandar, A. | 登録日 | 2017-07-11 | 公開日 | 2017-10-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Photorhabdus luminescens lectin A (PllA): A new probe for detecting alpha-galactoside-terminating glycoconjugates. J. Biol. Chem., 292, 2017
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5ODU
| PllA lectin, monosaccharide complex | 分子名称: | CALCIUM ION, PllA, methyl alpha-D-galactopyranoside | 著者 | Koehnke, J, Sikandar, A. | 登録日 | 2017-07-06 | 公開日 | 2017-10-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Photorhabdus luminescens lectin A (PllA): A new probe for detecting alpha-galactoside-terminating glycoconjugates. J. Biol. Chem., 292, 2017
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7NLK
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6CAD
| Crystal structure of RAF kinase domain bound to the inhibitor 2a | 分子名称: | 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Serine/threonine-protein kinase B-raf | 著者 | Maisonneuve, P, Kurinov, I, Assadieskandar, A, Yu, C, Liu, X, Chen, Y.-C, Prakash, G.K.S, Zhang, C, SIcheri, F. | 登録日 | 2018-01-30 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Effects of rigidity on the selectivity of protein kinase inhibitors. Eur J Med Chem, 146, 2018
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6F8B
| LasB bound to thiol based inhibitor | 分子名称: | CALCIUM ION, Elastase, ZINC ION, ... | 著者 | Koehnke, J, Sikandar, A. | 登録日 | 2017-12-12 | 公開日 | 2018-03-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa. ACS Infect Dis, 4, 2018
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5O28
| E. coli FolD apo | 分子名称: | Bifunctional protein FolD | 著者 | Koehnke, J, Sikandar, A. | 登録日 | 2017-05-19 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD. Nat Commun, 8, 2017
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5O2A
| FolD Q98H | 分子名称: | Bifunctional protein FolD | 著者 | Koehnke, J, Sikandar, A. | 登録日 | 2017-05-19 | 公開日 | 2018-02-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD. Nat Commun, 8, 2017
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5O22
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6I5S
| AH, Bottromycin amidohydrolase | 分子名称: | CHLORIDE ION, GLYCEROL, ZINC ION, ... | 著者 | Koehnke, J, Sikandar, A. | 登録日 | 2018-11-14 | 公開日 | 2019-09-25 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Thiazoline-Specific Amidohydrolase PurAH Is the Gatekeeper of Bottromycin Biosynthesis. J.Am.Chem.Soc., 141, 2019
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