6SXB
| XPF-ERCC1 Cryo-EM Structure, DNA-Bound form | 分子名称: | DNA (5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*TP*G)-3'), DNA (5'-D(P*CP*AP*GP*AP*TP*GP*CP*TP*GP*A)-3'), DNA excision repair protein ERCC-1, ... | 著者 | Jones, M.L, Briggs, D.C, McDonald, N.Q. | 登録日 | 2019-09-25 | 公開日 | 2020-03-11 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | 主引用文献 | Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nat Commun, 11, 2020
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6SXA
| XPF-ERCC1 Cryo-EM Structure, Apo-form | 分子名称: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF | 著者 | Jones, M.L, Briggs, D.C, McDonald, N.Q. | 登録日 | 2019-09-25 | 公開日 | 2020-03-11 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation. Nat Commun, 11, 2020
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8B9D
| Human replisome bound by Pol Alpha | 分子名称: | Cell division control protein 45 homolog, Claspin, DNA Molecule, ... | 著者 | Jones, M.L, Yeeles, J.T.P. | 登録日 | 2022-10-05 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
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8B9C
| S. cerevisiae pol alpha - replisome complex | 分子名称: | Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha catalytic subunit A, ... | 著者 | Jones, M.L, Yeeles, J.T.P. | 登録日 | 2022-10-05 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
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8B9B
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8B9A
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1Z3N
| Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, aldose reductase, {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID | 著者 | Van Zandt, M.C, Jones, M.L, Gunn, D.E, Geraci, L.S, Jones, J.H, Sawicki, D.R, Sredy, J, Jacot, J.L, Dicioccio, A.T, Petrova, T, Mitschler, A, Podjarny, A.D. | 登録日 | 2005-03-14 | 公開日 | 2006-03-14 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications J.Med.Chem., 48, 2005
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