5HCD
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![BU of 5hcd by Molmil](/molmil-images/mine/5hcd) | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
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5HCE
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![BU of 5hce by Molmil](/molmil-images/mine/5hce) | Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus appendiculatus RaCI1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ... | 著者 | Jore, M.M, Johnson, S, Lea, S.M. | 登録日 | 2016-01-04 | 公開日 | 2016-03-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Structural basis for therapeutic inhibition of complement C5. Nat.Struct.Mol.Biol., 23, 2016
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4AQB
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![BU of 4aqb by Molmil](/molmil-images/mine/4aqb) | MBL-Ficolin Associated Protein-1, MAP-1 aka MAP44 | 分子名称: | CALCIUM ION, MANNAN-BINDING LECTIN SERINE PROTEASE 1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Skjoedt, M.O, Roversi, P, Hummelshoj, T, Palarasah, Y, Johnson, S, Lea, S.M, Garred, P. | 登録日 | 2012-04-16 | 公開日 | 2012-08-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Crystal Structure and Functional Characterization of the Complement Regulator Mannose-Binding Lectin (Mbl)/Ficolin-Associated Protein-1 (Map-1). J.Biol.Chem., 287, 2012
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8UCS
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6SAN
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![BU of 6san by Molmil](/molmil-images/mine/6san) | SALSA / DMBT1 / GP340 SRCR domain 8 soaked in calcium and magnesium | 分子名称: | CHLORIDE ION, Deleted in malignant brain tumors 1 protein, GLYCEROL, ... | 著者 | Reichhardt, M.P, Johnson, S, Loimaranta, V, Lea, S.M. | 登録日 | 2019-07-17 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold. Life Sci Alliance, 3, 2020
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6SA5
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![BU of 6sa5 by Molmil](/molmil-images/mine/6sa5) | SALSA / DMBT1 / GP340 SRCR domain 8 | 分子名称: | Deleted in malignant brain tumors 1 protein, GLYCEROL, MAGNESIUM ION, ... | 著者 | Reichhardt, M.P, Johnson, S, Loimaranta, V, Lea, S.M. | 登録日 | 2019-07-16 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold. Life Sci Alliance, 3, 2020
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6SA4
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![BU of 6sa4 by Molmil](/molmil-images/mine/6sa4) | SALSA / DMBT1 / GP340 SRCR domain 1 | 分子名称: | CHLORIDE ION, Deleted in malignant brain tumors 1 protein, GLYCEROL, ... | 著者 | Reichhardt, M.P, Lea, S.M, Johnson, S. | 登録日 | 2019-07-16 | 公開日 | 2020-03-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold. Life Sci Alliance, 3, 2020
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6RQJ
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![BU of 6rqj by Molmil](/molmil-images/mine/6rqj) | Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5, Complement inhibitor, ... | 著者 | Reichhardt, M.P, Johnson, S, Lea, S.M. | 登録日 | 2019-05-15 | 公開日 | 2020-01-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | An inhibitor of complement C5 provides structural insights into activation. Proc.Natl.Acad.Sci.USA, 117, 2020
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6RPT
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6B2E
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![BU of 6b2e by Molmil](/molmil-images/mine/6b2e) | Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4. | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. | 登録日 | 2017-09-19 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25, 2018
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6B1U
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![BU of 6b1u by Molmil](/molmil-images/mine/6b1u) | Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4 | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. | 登録日 | 2017-09-19 | 公開日 | 2018-04-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25, 2018
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2W80
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![BU of 2w80 by Molmil](/molmil-images/mine/2w80) | Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H | 分子名称: | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | 著者 | Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M. | 登録日 | 2009-01-08 | 公開日 | 2009-03-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates. Nature, 458, 2009
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2W81
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![BU of 2w81 by Molmil](/molmil-images/mine/2w81) | Structure of a complex between Neisseria meningitidis factor H binding protein and CCPs 6-7 of human complement factor H | 分子名称: | COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN | 著者 | Schneider, M.C, Prosser, B.E, Caesar, J.J.E, Kugelberg, E, Li, S, Zhang, Q, Quoraishi, S, Lovett, J.E, Deane, J.E, Sim, R.B, Roversi, P, Johnson, S, Tang, C.M, Lea, S.M. | 登録日 | 2009-01-08 | 公開日 | 2009-03-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Neisseria Meningitidis Recruits Factor H Using Protein Mimicry of Host Carbohydrates. Nature, 458, 2009
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2IXR
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![BU of 2ixr by Molmil](/molmil-images/mine/2ixr) | BipD of Burkholderia Pseudomallei | 分子名称: | MEMBRANE ANTIGEN | 著者 | Roversi, P, Johnson, S, Field, T, Deane, J.E, Galyov, E.E, Lea, S.M. | 登録日 | 2006-07-10 | 公開日 | 2006-11-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Self-Chaperoning of the Type III Secretion System Needle Tip Proteins Ipad and Bipd. J.Biol.Chem., 282, 2007
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2V6L
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![BU of 2v6l by Molmil](/molmil-images/mine/2v6l) | Molecular Model of a Type III Secretion System Needle | 分子名称: | MXIH | 著者 | Deane, J.E, Roversi, P, Cordes, F.S, Johnson, S, Kenjale, R, Daniell, S, Booy, F, Picking, W.L, Picking, W.D, Blocker, A.J, Lea, S.M. | 登録日 | 2007-07-19 | 公開日 | 2007-07-31 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (16 Å) | 主引用文献 | Molecular model of a type III secretion system needle: Implications for host-cell sensing. Proc. Natl. Acad. Sci. U.S.A., 103, 2006
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2XXS
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![BU of 2xxs by Molmil](/molmil-images/mine/2xxs) | Solution structure of the N-terminal domain of the Shigella type III secretion protein MxiG | 分子名称: | PROTEIN MXIG | 著者 | McDowell, M.A, Johnson, S, Deane, J.E, McDonnell, J.M, Lea, S.M. | 登録日 | 2010-11-11 | 公開日 | 2011-07-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Functional Studies on the N-Terminal Domain of the Shigella Type III Secretion Protein Mxig. J.Biol.Chem., 286, 2011
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2V8E
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![BU of 2v8e by Molmil](/molmil-images/mine/2v8e) | Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CHLORIDE ION, COMPLEMENT FACTOR H, ... | 著者 | Prosser, B.E, Johnson, S, Roversi, P, Herbert, A.P, Blaum, B.S, Tyrrell, J, Jowitt, T.A, Clark, S.J, Tarelli, E, Uhrin, D, Barlow, P.N, Sim, R.B, Day, A.J, Lea, S.M. | 登録日 | 2007-08-07 | 公開日 | 2007-10-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration. J.Exp.Med., 204, 2007
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2UWN
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![BU of 2uwn by Molmil](/molmil-images/mine/2uwn) | Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand. | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ACETATE ION, CHLORIDE ION, ... | 著者 | Prosser, B.E, Johnson, S, Roversi, P, Herbert, A.P, Blaum, B.S, Tyrrell, J, Jowitt, T.A, Clark, S.J, Terelli, E, Uhrin, D, Barlow, P.N, Sim, R.B, Day, A.J, Lea, S.M. | 登録日 | 2007-03-22 | 公開日 | 2007-10-02 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration. J.Exp.Med., 204, 2007
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2XRC
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![BU of 2xrc by Molmil](/molmil-images/mine/2xrc) | Human complement factor I | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HUMAN COMPLEMENT FACTOR I | 著者 | Roversi, P, Johnson, S, Lea, S.M. | 登録日 | 2010-09-13 | 公開日 | 2011-07-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms. Proc.Natl.Acad.Sci.USA, 108, 2011
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2VIX
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![BU of 2vix by Molmil](/molmil-images/mine/2vix) | Methylated Shigella flexneri MxiC | 分子名称: | ACETATE ION, GLYCEROL, PROTEIN MXIC | 著者 | Deane, J.E, Roversi, P, King, C, Johnson, S, Lea, S.M. | 登録日 | 2007-12-05 | 公開日 | 2008-03-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structures of the Shigella Flexneri Type 3 Secretion System Protein Mxic Reveal Conformational Variability Amongst Homologues. J.Mol.Biol., 377, 2008
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2UX2
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![BU of 2ux2 by Molmil](/molmil-images/mine/2ux2) | High resolution structure of human CD59 | 分子名称: | CD59 GLYCOPROTEIN | 著者 | Leath, K.J, Johnson, S, Roversi, P, Morgan, B.P, Smith, R.A.G, Lea, S.M. | 登録日 | 2007-03-26 | 公開日 | 2007-08-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | High-Resolution Structures of Bacterially Expressed Soluble Human Cd59. Acta Crystallogr.,Sect.F, 63, 2007
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2UWR
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![BU of 2uwr by Molmil](/molmil-images/mine/2uwr) | High resolution structure of human CD59 | 分子名称: | CD59 GLYCOPROTEIN | 著者 | Leath, K.J, Johnson, S, Roversi, P, Morgan, B.P, Smith, R.A.G, Lea, S.M. | 登録日 | 2007-03-23 | 公開日 | 2007-08-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | High-Resolution Structures of Bacterially Expressed Soluble Human Cd59. Acta Crystallogr.,Sect.F, 63, 2007
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2XGA
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![BU of 2xga by Molmil](/molmil-images/mine/2xga) | MTSL spin-labelled Shigella Flexneri Spa15 | 分子名称: | S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, SURFACE PRESENTATION OF ANTIGENS PROTEIN SPAK | 著者 | Lillington, J.E.D, Johnson, S, Lea, S.M. | 登録日 | 2010-06-02 | 公開日 | 2010-12-01 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Shigella Flexneri Spa15 Crystal Structure Verified in Solution by Double Electron Electron Resonance. J.Mol.Biol., 405, 2011
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2VJ5
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![BU of 2vj5 by Molmil](/molmil-images/mine/2vj5) | Shigella flexneri MxiC | 分子名称: | PROTEIN MXIC | 著者 | Deane, J.E, Roversi, P, King, C, Johnson, S, Lea, S.M. | 登録日 | 2007-12-06 | 公開日 | 2008-03-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structures of the Shigella Flexneri Type 3 Secretion System Protein Mxic Reveal Conformational Variability Amongst Homologues. J.Mol.Biol., 377, 2008
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2VJ4
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![BU of 2vj4 by Molmil](/molmil-images/mine/2vj4) | Methylated Shigella flexneri MxiC | 分子名称: | PROTEIN MXIC | 著者 | Deane, J.E, Roversi, P, King, C, Johnson, S, Lea, S.M. | 登録日 | 2007-12-06 | 公開日 | 2008-03-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of the Shigella Flexneri Type 3 Secretion System Protein Mxic Reveal Conformational Variability Amongst Homologues. J.Mol.Biol., 377, 2008
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